(16 nodes) CD28 dependent Vav1 pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CDC42	Cell division cycle 42. (191 aa)
	LOC103472837	Uncharacterized protein. (196 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	cd276	CD276 molecule. (298 aa)
	LOC103458742	Tyrosine-protein kinase. (537 aa)
	LOC103475569	Uncharacterized protein. (222 aa)
	LOC103458433	Non-specific serine/threonine protein kinase. (507 aa)
	LOC103477993	Uncharacterized protein. (134 aa)
	LOC103477991	Uncharacterized protein. (191 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	pak1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	LOC103465423	Cell division cycle 42. (191 aa)
	vtcn1	V-set domain containing T cell activation inhibitor 1. (271 aa)
	LOC103458010	Tyrosine-protein kinase. (537 aa)
	pak2	Non-specific serine/threonine protein kinase. (525 aa)
	PAK3	Non-specific serine/threonine protein kinase. (575 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	LOC103458010	ENSPREP00000005959	ENSPREP00000030555	Cell division cycle 42.	Tyrosine-protein kinase.	0.500
CDC42	LOC103458433	ENSPREP00000005959	ENSPREP00000016553	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.982
CDC42	LOC103458742	ENSPREP00000005959	ENSPREP00000009827	Cell division cycle 42.	Tyrosine-protein kinase.	0.500
CDC42	LOC103472837	ENSPREP00000005959	ENSPREP00000001820	Cell division cycle 42.	Uncharacterized protein.	0.900
CDC42	LOC103477991	ENSPREP00000005959	ENSPREP00000017385	Cell division cycle 42.	Uncharacterized protein.	0.901
CDC42	PAK3	ENSPREP00000005959	ENSPREP00000034117	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.988
CDC42	grb2	ENSPREP00000005959	ENSPREP00000022510	Cell division cycle 42.	Growth factor receptor-bound protein 2b.	0.669
CDC42	lck	ENSPREP00000005959	ENSPREP00000003459	Cell division cycle 42.	Tyrosine-protein kinase.	0.451
CDC42	pak1	ENSPREP00000005959	ENSPREP00000025701	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.891
CDC42	pak2	ENSPREP00000005959	ENSPREP00000030798	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.982
LOC103458010	CDC42	ENSPREP00000030555	ENSPREP00000005959	Tyrosine-protein kinase.	Cell division cycle 42.	0.500
LOC103458010	LOC103458433	ENSPREP00000030555	ENSPREP00000016553	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.433
LOC103458010	LOC103465423	ENSPREP00000030555	ENSPREP00000026666	Tyrosine-protein kinase.	Cell division cycle 42.	0.500
LOC103458010	LOC103472837	ENSPREP00000030555	ENSPREP00000001820	Tyrosine-protein kinase.	Uncharacterized protein.	0.405
LOC103458010	LOC103477991	ENSPREP00000030555	ENSPREP00000017385	Tyrosine-protein kinase.	Uncharacterized protein.	0.405
LOC103458010	LOC103477993	ENSPREP00000030555	ENSPREP00000016909	Tyrosine-protein kinase.	Uncharacterized protein.	0.405
LOC103458010	PAK3	ENSPREP00000030555	ENSPREP00000034117	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase.	0.452
LOC103458010	grb2	ENSPREP00000030555	ENSPREP00000022510	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2b.	0.612
LOC103458010	lck	ENSPREP00000030555	ENSPREP00000003459	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.443
LOC103458010	pak1	ENSPREP00000030555	ENSPREP00000025701	Tyrosine-protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.452