(35 nodes) Glyoxylate metabolism and glycine degradation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000026406	Oxoglutarate dehydrogenase. (353 aa)
	gcsh	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. (174 aa)
	prodh2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (472 aa)
	lipt1	Lipoyltransferase 1. (404 aa)
	dao	D-amino-acid oxidase, tandem duplicate 2. (316 aa)
	aldh4a1	Delta-1-pyrroline-5-carboxylate dehydrogenase; Belongs to the aldehyde dehydrogenase family. (592 aa)
	LOC103475424	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	LOC103475425	Uncharacterized protein. (609 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (436 aa)
	ndufab1	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (156 aa)
	pdhx	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	LOC103463960	Serine--pyruvate aminotransferase. (434 aa)
	got2	Aspartate aminotransferase. (393 aa)
	bckdhb	Branched chain keto acid dehydrogenase E1 subunit beta. (387 aa)
	ogdh	Oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide). (1019 aa)
	ENSPREP00000023632	2-Hacid_dh_C domain-containing protein. (103 aa)
	bckdha	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (447 aa)
	ddo	Zgc:172341. (338 aa)
	agxt2	Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (517 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
	lipt2	Putative lipoyltransferase 2, mitochondrial; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. Belongs to the LipB family. (231 aa)
	dld	Dihydrolipoyl dehydrogenase. (508 aa)
	grhpr	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
	amt	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family. (415 aa)
	ENSPREP00000006862	Uncharacterized protein. (144 aa)
	dbt	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (492 aa)
	LOC103461416	Serine--pyruvate aminotransferase. (360 aa)
	LOC103466594	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (359 aa)
	lias	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (398 aa)
	gldc	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. (1043 aa)
	LOC103472444	Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
	LOC103459060	Dihydrolipoamide S-succinyltransferase. (433 aa)
	ENSPREP00000014189	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (202 aa)
	hao1	Hydroxyacid oxidase (glycolate oxidase) 1. (373 aa)
	pdha1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (400 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLST	ENSPREP00000006862	ENSPREP00000028927	ENSPREP00000006862	Dihydrolipoamide S-succinyltransferase.	Uncharacterized protein.	0.753
DLST	ENSPREP00000014189	ENSPREP00000028927	ENSPREP00000014189	Dihydrolipoamide S-succinyltransferase.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.963
DLST	ENSPREP00000023632	ENSPREP00000028927	ENSPREP00000023632	Dihydrolipoamide S-succinyltransferase.	2-Hacid_dh_C domain-containing protein.	0.452
DLST	ENSPREP00000026406	ENSPREP00000028927	ENSPREP00000026406	Dihydrolipoamide S-succinyltransferase.	Oxoglutarate dehydrogenase.	0.985
DLST	LOC103466594	ENSPREP00000028927	ENSPREP00000009314	Dihydrolipoamide S-succinyltransferase.	Glyoxylate reductase/hydroxypyruvate reductase b; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.452
DLST	LOC103472444	ENSPREP00000028927	ENSPREP00000013109	Dihydrolipoamide S-succinyltransferase.	Zgc:136493; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.452
DLST	LOC103475424	ENSPREP00000028927	ENSPREP00000029554	Dihydrolipoamide S-succinyltransferase.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.775
DLST	LOC103475425	ENSPREP00000028927	ENSPREP00000029465	Dihydrolipoamide S-succinyltransferase.	Uncharacterized protein.	0.731
DLST	amt	ENSPREP00000028927	ENSPREP00000005551	Dihydrolipoamide S-succinyltransferase.	Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine; Belongs to the GcvT family.	0.534
DLST	bckdha	ENSPREP00000028927	ENSPREP00000024063	Dihydrolipoamide S-succinyltransferase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.954
DLST	bckdhb	ENSPREP00000028927	ENSPREP00000022601	Dihydrolipoamide S-succinyltransferase.	Branched chain keto acid dehydrogenase E1 subunit beta.	0.945
DLST	dbt	ENSPREP00000028927	ENSPREP00000008184	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.701
DLST	dlat	ENSPREP00000028927	ENSPREP00000026249	Dihydrolipoamide S-succinyltransferase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.901
DLST	dld	ENSPREP00000028927	ENSPREP00000003162	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoyl dehydrogenase.	0.999
DLST	gcsh	ENSPREP00000028927	ENSPREP00000034245	Dihydrolipoamide S-succinyltransferase.	Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family.	0.753
DLST	gldc	ENSPREP00000028927	ENSPREP00000012159	Dihydrolipoamide S-succinyltransferase.	Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine.	0.778
DLST	got2	ENSPREP00000028927	ENSPREP00000021995	Dihydrolipoamide S-succinyltransferase.	Aspartate aminotransferase.	0.484
DLST	grhpr	ENSPREP00000028927	ENSPREP00000003287	Dihydrolipoamide S-succinyltransferase.	Glyoxylate reductase/hydroxypyruvate reductase a; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	0.452
DLST	lias	ENSPREP00000028927	ENSPREP00000011074	Dihydrolipoamide S-succinyltransferase.	Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.	0.426
DLST	lipt1	ENSPREP00000028927	ENSPREP00000033072	Dihydrolipoamide S-succinyltransferase.	Lipoyltransferase 1.	0.856