(51 nodes) G-protein beta:gamma signalling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	LOC103462484	ZP domain-containing protein. (415 aa)
	PAK3	Non-specific serine/threonine protein kinase. (575 aa)
	LOC103475780	WD_REPEATS_REGION domain-containing protein. (223 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1272 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	mfsd6	Major facilitator superfamily domain containing 6a. (802 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	plcb3	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1208 aa)
	LOC103465423	Cell division cycle 42. (191 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (538 aa)
	pak1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
	gng2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	ENSPREP00000025109	Uncharacterized protein. (110 aa)
	pik3r5	Phosphoinositide-3-kinase, regulatory subunit 5. (799 aa)
	Plcb1	Uncharacterized protein. (33 aa)
	PLCB1	Phosphoinositide phospholipase C. (1031 aa)
	pik3cg	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma; Belongs to the PI3/PI4-kinase family. (1121 aa)
	ENSPREP00000022514	ZP domain-containing protein. (320 aa)
	LOC103468393	Phosphoinositide-3-kinase regulatory subunit 5. (832 aa)
	mfsd6l	Major facilitator superfamily domain containing 6-like. (585 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	gnb5	Guanine nucleotide binding protein (G protein), beta 5a. (380 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	LOC103463990	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	LOC103468320	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
	gnb3	Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (296 aa)
	gng3	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
	LOC103477991	Uncharacterized protein. (191 aa)
	LOC103477993	Uncharacterized protein. (134 aa)
	gng7	Guanine nucleotide binding protein (G protein), gamma 7. (78 aa)
	gnb1	Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
	arhgef6	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. (772 aa)
	LOC103481657	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	gng12	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (96 aa)
	LOC103468179	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC103462170	Guanine nucleotide binding protein (G protein), beta 5b. (345 aa)
	LOC103464516	Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
	LOC103476610	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1127 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC103466897	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1046 aa)
	gng10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	LOC103472243	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	ENSPREP00000002125	ZP domain-containing protein. (372 aa)
	LOC103472833	Guanine nucleotide binding protein (G protein), beta polypeptide 3b. (342 aa)
	LOC103472837	Uncharacterized protein. (196 aa)
	LOC103469304	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
	LOC103465545	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	LOC103462833	Guanine nucleotide binding protein (G protein), gamma 13a. (67 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	GNB4	ENSPREP00000005959	ENSPREP00000022213	Cell division cycle 42.	G protein subunit beta 4.	0.474
CDC42	GNG5	ENSPREP00000005959	ENSPREP00000021564	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.583
CDC42	LOC103462170	ENSPREP00000005959	ENSPREP00000007905	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta 5b.	0.532
CDC42	LOC103463990	ENSPREP00000005959	ENSPREP00000020582	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.405
CDC42	LOC103464516	ENSPREP00000005959	ENSPREP00000006363	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta polypeptide 1b.	0.474
CDC42	LOC103470003	ENSPREP00000005959	ENSPREP00000030956	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103472243	ENSPREP00000005959	ENSPREP00000003752	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.508
CDC42	LOC103472837	ENSPREP00000005959	ENSPREP00000001820	Cell division cycle 42.	Uncharacterized protein.	0.900
CDC42	LOC103474789	ENSPREP00000005959	ENSPREP00000008269	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103475780	ENSPREP00000005959	ENSPREP00000033242	Cell division cycle 42.	WD_REPEATS_REGION domain-containing protein.	0.474
CDC42	LOC103476681	ENSPREP00000005959	ENSPREP00000012589	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103477991	ENSPREP00000005959	ENSPREP00000017385	Cell division cycle 42.	Uncharacterized protein.	0.901
CDC42	PAK3	ENSPREP00000005959	ENSPREP00000034117	Cell division cycle 42.	Non-specific serine/threonine protein kinase.	0.988
CDC42	akt1	ENSPREP00000005959	ENSPREP00000031683	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	arhgef6	ENSPREP00000005959	ENSPREP00000015364	Cell division cycle 42.	Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6.	0.710
CDC42	gnb1	ENSPREP00000005959	ENSPREP00000015702	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta polypeptide 1a.	0.474
CDC42	gnb5	ENSPREP00000005959	ENSPREP00000021759	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), beta 5a.	0.532
CDC42	gng12	ENSPREP00000005959	ENSPREP00000012092	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.405
CDC42	gng3	ENSPREP00000005959	ENSPREP00000017524	Cell division cycle 42.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.503
CDC42	gng7	ENSPREP00000005959	ENSPREP00000015930	Cell division cycle 42.	Guanine nucleotide binding protein (G protein), gamma 7.	0.405