(26 nodes) SUMOylation of intracellular receptors network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000017463	Uncharacterized protein. (388 aa)
	nr1h3	Nuclear receptor subfamily 1, group H, member 3. (464 aa)
	LOC103471211	Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor). (765 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (745 aa)
	LOC103458735	Small ubiquitin-related modifier. (94 aa)
	ENSPREP00000011180	Nuclear receptor subfamily 5, group A, member 2. (465 aa)
	LOC103462108	Protein inhibitor of activated STAT, 1a. (658 aa)
	pias4	Protein inhibitor of activated STAT, 4a. (509 aa)
	LOC103461674	Ubiquitin-like domain-containing protein. (161 aa)
	LOC103466533	Protein inhibitor of activated STAT, 1b. (647 aa)
	LOC103460179	Uncharacterized protein. (545 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	THRA	Thyroid hormone receptor alpha. (413 aa)
	sumo2	Small ubiquitin-related modifier. (95 aa)
	ENSPREP00000020228	Thyroid hormone receptor beta. (482 aa)
	sumo1	Small ubiquitin like modifier 1. (205 aa)
	pgr	Progesterone receptor. (642 aa)
	LOC103467943	Small ubiquitin-related modifier. (96 aa)
	ube2i	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	LOC103468487	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	LOC103475709	Androgen receptor. (757 aa)
	ar	Androgen receptor. (685 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	nr3c2	Nuclear receptor subfamily 3, group C, member 2. (993 aa)
	nr1i2	Nuclear receptor subfamily 1, group I, member 2. (355 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000011180	LOC103458735	ENSPREP00000011180	ENSPREP00000009093	Nuclear receptor subfamily 5, group A, member 2.	Small ubiquitin-related modifier.	0.437
ENSPREP00000011180	LOC103460179	ENSPREP00000011180	ENSPREP00000016190	Nuclear receptor subfamily 5, group A, member 2.	Uncharacterized protein.	0.428
ENSPREP00000011180	LOC103461674	ENSPREP00000011180	ENSPREP00000013358	Nuclear receptor subfamily 5, group A, member 2.	Ubiquitin-like domain-containing protein.	0.437
ENSPREP00000011180	LOC103462108	ENSPREP00000011180	ENSPREP00000011832	Nuclear receptor subfamily 5, group A, member 2.	Protein inhibitor of activated STAT, 1a.	0.428
ENSPREP00000011180	LOC103466533	ENSPREP00000011180	ENSPREP00000015982	Nuclear receptor subfamily 5, group A, member 2.	Protein inhibitor of activated STAT, 1b.	0.428
ENSPREP00000011180	LOC103467943	ENSPREP00000011180	ENSPREP00000024574	Nuclear receptor subfamily 5, group A, member 2.	Small ubiquitin-related modifier.	0.437
ENSPREP00000011180	LOC103468487	ENSPREP00000011180	ENSPREP00000027513	Nuclear receptor subfamily 5, group A, member 2.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.614
ENSPREP00000011180	esr1	ENSPREP00000011180	ENSPREP00000006015	Nuclear receptor subfamily 5, group A, member 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.531
ENSPREP00000011180	nr1h3	ENSPREP00000011180	ENSPREP00000006124	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group H, member 3.	0.463
ENSPREP00000011180	nr1i2	ENSPREP00000011180	ENSPREP00000000959	Nuclear receptor subfamily 5, group A, member 2.	Nuclear receptor subfamily 1, group I, member 2.	0.520
ENSPREP00000011180	pias4	ENSPREP00000011180	ENSPREP00000012849	Nuclear receptor subfamily 5, group A, member 2.	Protein inhibitor of activated STAT, 4a.	0.477
ENSPREP00000011180	sumo1	ENSPREP00000011180	ENSPREP00000022120	Nuclear receptor subfamily 5, group A, member 2.	Small ubiquitin like modifier 1.	0.591
ENSPREP00000011180	sumo2	ENSPREP00000011180	ENSPREP00000002821	Nuclear receptor subfamily 5, group A, member 2.	Small ubiquitin-related modifier.	0.437
ENSPREP00000011180	ube2i	ENSPREP00000011180	ENSPREP00000026310	Nuclear receptor subfamily 5, group A, member 2.	Ubiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family.	0.614
ENSPREP00000017463	Rxra	ENSPREP00000017463	ENSPREP00000032811	Uncharacterized protein.	Retinoid X receptor, alpha a.	0.549
ENSPREP00000017463	THRA	ENSPREP00000017463	ENSPREP00000017754	Uncharacterized protein.	Thyroid hormone receptor alpha.	0.900
ENSPREP00000017463	sumo1	ENSPREP00000017463	ENSPREP00000022120	Uncharacterized protein.	Small ubiquitin like modifier 1.	0.406
ENSPREP00000020228	Rxra	ENSPREP00000020228	ENSPREP00000032811	Thyroid hormone receptor beta.	Retinoid X receptor, alpha a.	0.549
LOC103458735	ENSPREP00000011180	ENSPREP00000009093	ENSPREP00000011180	Small ubiquitin-related modifier.	Nuclear receptor subfamily 5, group A, member 2.	0.437
LOC103458735	LOC103460179	ENSPREP00000009093	ENSPREP00000016190	Small ubiquitin-related modifier.	Uncharacterized protein.	0.738