(106 nodes) Regulation of mitotic cell cycle network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	psmd13	Proteasome 26S subunit, non-ATPase 13. (258 aa)
	cdc26	Uncharacterized protein. (62 aa)
	ENSPREP00000024682	KxDL motif containing 1. (197 aa)
	LOC103478144	Proteasome 26S subunit, non-ATPase 4b. (363 aa)
	psmc4	Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (421 aa)
	psmb4	Proteasome subunit beta; Belongs to the peptidase T1B family. (259 aa)
	psmd8	Proteasome 26S subunit, non-ATPase 8. (278 aa)
	bicra	BRD4 interacting chromatin remodeling complex associated protein. (1687 aa)
	anapc7	Anaphase promoting complex subunit 7. (565 aa)
	psmf1	Proteasome inhibitor subunit 1. (261 aa)
	psmd7	Proteasome 26S subunit, non-ATPase 7. (330 aa)
	ube2c	Ubiquitin-conjugating enzyme E2C; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
	tm7sf3	Transmembrane 7 superfamily member 3. (550 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC103471497	Aurora kinase B; Belongs to the protein kinase superfamily. (350 aa)
	psma2	Proteasome endopeptidase complex. (164 aa)
	LOC103471961	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (206 aa)
	ube2e1	Ubiquitin-conjugating enzyme E2E 1; Belongs to the ubiquitin-conjugating enzyme family. (195 aa)
	psmc2	Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (438 aa)
	LOC103481710	Proteasome 26S subunit, non-ATPase 11b. (422 aa)
	cdc27	Cell division cycle 27. (803 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	pttg1	Uncharacterized protein. (177 aa)
	LOC103473123	Proteasome subunit beta. (278 aa)
	psmb7	Proteasome subunit beta. (307 aa)
	LOC103468289	PCI domain-containing protein. (442 aa)
	psmd3	Proteasome 26S subunit, non-ATPase 3. (527 aa)
	LOC103460926	Proteasome subunit beta. (275 aa)
	LOC103460925	Proteasome subunit beta. (275 aa)
	LOC103460924	Proteasome subunit beta 12. (217 aa)
	LOC103460923	Proteasome subunit beta. (216 aa)
	psme3	Proteasome activator subunit 3. (256 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (402 aa)
	psme1	Proteasome activator subunit 1. (250 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	cul1	Cullin 1b; Belongs to the cullin family. (776 aa)
	psmd2	26S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (906 aa)
	psmb2	Proteasome subunit beta. (199 aa)
	psmb1	Proteasome subunit beta. (241 aa)
	psmc3	Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (427 aa)
	bicral	BRD4 interacting chromatin remodeling complex associated protein like. (779 aa)
	psma6	Proteasome subunit alpha type. (254 aa)
	aurka	Aurora kinase A; Belongs to the protein kinase superfamily. (427 aa)
	LOC103460825	Proteasome subunit beta. (233 aa)
	LOC103474855	Proteasome endopeptidase complex. (248 aa)
	ube2s	Ubiquitin-conjugating enzyme E2S; Belongs to the ubiquitin-conjugating enzyme family. (203 aa)
	nek2	NIMA-related kinase 2. (352 aa)
	bub3	BUB3 mitotic checkpoint protein. (326 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (308 aa)
	ENSPREP00000009964	Ubiquitin-like domain-containing protein. (95 aa)
	ubb	Uncharacterized protein. (179 aa)
	psmd1	26S proteasome non-ATPase regulatory subunit 1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S1 family. (952 aa)
	skp2	F-box domain-containing protein. (426 aa)
	psma4	Proteasome subunit alpha type. (261 aa)
	LOC103481555	Proteasome activator subunit 4b. (1781 aa)
	cdc16	Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
	anapc2	Anaphase promoting complex subunit 2; Belongs to the cullin family. (742 aa)
	LOC103479019	Fizzy/cell division cycle 20 related 1b. (396 aa)
	skp1	S-phase kinase-associated protein 1; Belongs to the SKP1 family. (107 aa)
	LOC103479568	Proteasome subunit alpha type. (251 aa)
	LOC103472928	Proteasome subunit beta. (216 aa)
	LOC103472926	Proteasome subunit beta 12. (217 aa)
	LOC103472927	Proteasome subunit beta. (275 aa)
	LOC103472925	Proteasome subunit beta. (275 aa)
	psma3	Proteasome subunit alpha type. (253 aa)
	anapc11	APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
	psmb3	Proteasome subunit beta. (202 aa)
	psma5	Proteasome subunit alpha type. (253 aa)
	cdc20	Cell division cycle 20 homolog. (555 aa)
	anapc10	Anaphase promoting complex subunit 10. (184 aa)
	LOC103477709	Ubiquitin-conjugating enzyme E2E 2; Belongs to the ubiquitin-conjugating enzyme family. (201 aa)
	fbxo5	F-box protein 5. (376 aa)
	anapc1	Anaphase promoting complex subunit 1. (1878 aa)
	anapc16	Anaphase promoting complex subunit 16. (108 aa)
	LOC103477708	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (194 aa)
	psmd5	Proteasome 26S subunit, non-ATPase 5. (505 aa)
	psmc6	Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (389 aa)
	psmd12	Proteasome 26S subunit, non-ATPase 12. (456 aa)
	psma1	Proteasome endopeptidase complex. (276 aa)
	psmd10	Proteasome 26S subunit, non-ATPase 10. (226 aa)
	mad2l1	MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
	bub1b	BUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
	ENSPREP00000032595	Proteasome subunit beta. (290 aa)
	LOC103478894	Proteasome subunit beta. (296 aa)
	ENSPREP00000032744	Retinoblastoma 1. (864 aa)
	psme2	Proteasome activator subunit 2. (256 aa)
	psmc5	Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (408 aa)
	psme4	Proteasome activator subunit 4a. (1850 aa)
	cdc23	CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
	psmd9	Proteasome 26S subunit, non-ATPase 9. (210 aa)
	ENSPREP00000030697	Uncharacterized protein. (754 aa)
	FBXO43	F-box protein 43. (591 aa)
	anapc5	Anaphase promoting complex subunit 5. (773 aa)
	ccnb1	Cyclin B1; Belongs to the cyclin family. (401 aa)
	psmd14	Proteasome 26S subunit, non-ATPase 14. (310 aa)
	LOC103472718	Proteasome 26S subunit, non-ATPase 4a. (377 aa)
	anapc15	Anaphase promoting complex subunit 15. (122 aa)
	anapc4	Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
	psmd6	Proteasome 26S subunit, non-ATPase 6. (369 aa)
	LOC103457804	Proteasome subunit alpha type. (246 aa)
	psmc1	Proteasome 26S subunit, ATPase 1b; Belongs to the AAA ATPase family. (440 aa)
	LOC103463873	Proteasome subunit beta11b. (386 aa)
	FZR1	Fizzy/cell division cycle 20 related 1a. (470 aa)
	fam89a	Family with sequence similarity 89 member A. (177 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009964	ENSPREP00000024682	ENSPREP00000009964	ENSPREP00000024682	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.594
ENSPREP00000009964	ENSPREP00000032595	ENSPREP00000009964	ENSPREP00000032595	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.571
ENSPREP00000009964	ENSPREP00000032744	ENSPREP00000009964	ENSPREP00000032744	Ubiquitin-like domain-containing protein.	Retinoblastoma 1.	0.590
ENSPREP00000009964	FZR1	ENSPREP00000009964	ENSPREP00000026428	Ubiquitin-like domain-containing protein.	Fizzy/cell division cycle 20 related 1a.	0.591
ENSPREP00000009964	LOC103457804	ENSPREP00000009964	ENSPREP00000027505	Ubiquitin-like domain-containing protein.	Proteasome subunit alpha type.	0.737
ENSPREP00000009964	LOC103460825	ENSPREP00000009964	ENSPREP00000012559	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.688
ENSPREP00000009964	LOC103460923	ENSPREP00000009964	ENSPREP00000017220	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.688
ENSPREP00000009964	LOC103460924	ENSPREP00000009964	ENSPREP00000017235	Ubiquitin-like domain-containing protein.	Proteasome subunit beta 12.	0.688
ENSPREP00000009964	LOC103460925	ENSPREP00000009964	ENSPREP00000017260	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.667
ENSPREP00000009964	LOC103460926	ENSPREP00000009964	ENSPREP00000017301	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.717
ENSPREP00000009964	LOC103463873	ENSPREP00000009964	ENSPREP00000027047	Ubiquitin-like domain-containing protein.	Proteasome subunit beta11b.	0.571
ENSPREP00000009964	LOC103468289	ENSPREP00000009964	ENSPREP00000017396	Ubiquitin-like domain-containing protein.	PCI domain-containing protein.	0.782
ENSPREP00000009964	LOC103471497	ENSPREP00000009964	ENSPREP00000020685	Ubiquitin-like domain-containing protein.	Aurora kinase B; Belongs to the protein kinase superfamily.	0.504
ENSPREP00000009964	LOC103471961	ENSPREP00000009964	ENSPREP00000020367	Ubiquitin-like domain-containing protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.588
ENSPREP00000009964	LOC103472718	ENSPREP00000009964	ENSPREP00000029622	Ubiquitin-like domain-containing protein.	Proteasome 26S subunit, non-ATPase 4a.	0.856
ENSPREP00000009964	LOC103472925	ENSPREP00000009964	ENSPREP00000006539	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.717
ENSPREP00000009964	LOC103472926	ENSPREP00000009964	ENSPREP00000006580	Ubiquitin-like domain-containing protein.	Proteasome subunit beta 12.	0.688
ENSPREP00000009964	LOC103472927	ENSPREP00000009964	ENSPREP00000006561	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.667
ENSPREP00000009964	LOC103472928	ENSPREP00000009964	ENSPREP00000006606	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.688
ENSPREP00000009964	LOC103473123	ENSPREP00000009964	ENSPREP00000018126	Ubiquitin-like domain-containing protein.	Proteasome subunit beta.	0.700