(26 nodes) FRS-mediated FGFR4 signaling network (Poecilia reticulata)

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Your Input:
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
	LOC103471324	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	fgf19	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family. (196 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	frs3	Fibroblast growth factor receptor substrate 3. (627 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	LOC103471871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (912 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103469088	Zgc:55558. (191 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
	FGF6-2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSPREP00000006768	ENSPREP00000017340	ENSPREP00000006768	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.406
CSDE1	LOC103471324	ENSPREP00000017340	ENSPREP00000002038	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.478
CSDE1	LOC103471871	ENSPREP00000017340	ENSPREP00000009989	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
CSDE1	LOC103476521	ENSPREP00000017340	ENSPREP00000029747	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
CSDE1	fgf1	ENSPREP00000017340	ENSPREP00000007991	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.406
CSDE1	fgf17	ENSPREP00000017340	ENSPREP00000019823	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.435
CSDE1	fgf19	ENSPREP00000017340	ENSPREP00000002527	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.419
CSDE1	fgf23	ENSPREP00000017340	ENSPREP00000033759	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	frs2	ENSPREP00000017340	ENSPREP00000005417	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.437
CSDE1	frs3	ENSPREP00000017340	ENSPREP00000002675	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.437
CSDE1	grb2	ENSPREP00000017340	ENSPREP00000022510	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.667
ENSPREP00000004603	ENSPREP00000010497	ENSPREP00000004603	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	0.447
ENSPREP00000004603	LOC103476521	ENSPREP00000004603	ENSPREP00000029747	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.511
ENSPREP00000004603	fgf19	ENSPREP00000004603	ENSPREP00000002527	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 19; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	fgf23	ENSPREP00000004603	ENSPREP00000033759	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.569
ENSPREP00000004603	grb2	ENSPREP00000004603	ENSPREP00000022510	Uncharacterized protein; Belongs to the heparin-binding growth factors family.	Growth factor receptor-bound protein 2b.	0.488
ENSPREP00000006768	CSDE1	ENSPREP00000006768	ENSPREP00000017340	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Cold shock domain containing E1, RNA-binding.	0.406
ENSPREP00000006768	LOC103462291	ENSPREP00000006768	ENSPREP00000002555	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.429
ENSPREP00000006768	LOC103469088	ENSPREP00000006768	ENSPREP00000020359	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Zgc:55558.	0.406
ENSPREP00000006768	LOC103471324	ENSPREP00000006768	ENSPREP00000002038	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.502