(54 nodes) Signaling by FGFR3 network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	fgf23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (266 aa)
	Fgf20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa)
	gab1	GRB2-associated binding protein 1. (756 aa)
	LOC103471324	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC103462291	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (188 aa)
	frs3	Fibroblast growth factor receptor substrate 3. (627 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	fgf5	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (218 aa)
	ENSPREP00000004603	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (62 aa)
	frs2	Fibroblast growth factor receptor substrate 2b. (521 aa)
	fgf16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (190 aa)
	ENSPREP00000006768	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (152 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	fgf1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (173 aa)
	LOC103471193	Serine/threonine-protein phosphatase. (309 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	ubb	Uncharacterized protein. (179 aa)
	LOC103471871	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (210 aa)
	LOC103467626	Glyco_trans_2-like domain-containing protein. (572 aa)
	ENSPREP00000010497	Uncharacterized protein; Belongs to the heparin-binding growth factors family. (173 aa)
	GALNT3	Polypeptide N-acetylgalactosaminyltransferase. (624 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	LOC103476047	Sprouty RTK signaling antagonist 2. (349 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (425 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	CSDE1	Cold shock domain containing E1, RNA-binding. (912 aa)
	fndc3b	Fibronectin type III domain containing 3Ba. (1175 aa)
	LOC103480707	PH domain-containing protein. (763 aa)
	ENSPREP00000018426	Uncharacterized protein. (108 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	fgf17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103469088	Zgc:55558. (191 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	fndc3a	Fibronectin type III domain containing 3A. (1236 aa)
	LOC103477907	Cbl proto-oncogene C, E3 ubiquitin protein ligase. (550 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC103476312	Uncharacterized protein. (857 aa)
	LOC103469111	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	ENSPREP00000022877	Uncharacterized protein. (62 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (304 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC103476521	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	LOC103467317	Polypeptide N-acetylgalactosaminyltransferase. (620 aa)
	LOC103470957	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	cbl	Cbl proto-oncogene, E3 ubiquitin protein ligase. (848 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (613 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CSDE1	ENSPREP00000006768	ENSPREP00000017340	ENSPREP00000006768	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.406
CSDE1	LOC103467856	ENSPREP00000017340	ENSPREP00000031006	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	LOC103469111	ENSPREP00000017340	ENSPREP00000022587	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.462
CSDE1	LOC103471324	ENSPREP00000017340	ENSPREP00000002038	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 18a; Belongs to the heparin-binding growth factors family.	0.478
CSDE1	LOC103471871	ENSPREP00000017340	ENSPREP00000009989	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
CSDE1	LOC103473189	ENSPREP00000017340	ENSPREP00000021152	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein.	0.450
CSDE1	LOC103475907	ENSPREP00000017340	ENSPREP00000003309	Cold shock domain containing E1, RNA-binding.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	LOC103476521	ENSPREP00000017340	ENSPREP00000029747	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.449
CSDE1	LOC103479066	ENSPREP00000017340	ENSPREP00000009342	Cold shock domain containing E1, RNA-binding.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.524
CSDE1	Pik3ca	ENSPREP00000017340	ENSPREP00000033418	Cold shock domain containing E1, RNA-binding.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.524
CSDE1	SRC	ENSPREP00000017340	ENSPREP00000016288	Cold shock domain containing E1, RNA-binding.	Tyrosine-protein kinase.	0.423
CSDE1	fgf1	ENSPREP00000017340	ENSPREP00000007991	Cold shock domain containing E1, RNA-binding.	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...]	0.406
CSDE1	fgf17	ENSPREP00000017340	ENSPREP00000019823	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.435
CSDE1	fgf23	ENSPREP00000017340	ENSPREP00000033759	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family.	0.427
CSDE1	fgf5	ENSPREP00000017340	ENSPREP00000004455	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.424
CSDE1	frs2	ENSPREP00000017340	ENSPREP00000005417	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 2b.	0.437
CSDE1	frs3	ENSPREP00000017340	ENSPREP00000002675	Cold shock domain containing E1, RNA-binding.	Fibroblast growth factor receptor substrate 3.	0.437
CSDE1	grb2	ENSPREP00000017340	ENSPREP00000022510	Cold shock domain containing E1, RNA-binding.	Growth factor receptor-bound protein 2b.	0.667
CSDE1	mapk1	ENSPREP00000017340	ENSPREP00000019735	Cold shock domain containing E1, RNA-binding.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.462
CSDE1	ppp2r1b	ENSPREP00000017340	ENSPREP00000033194	Cold shock domain containing E1, RNA-binding.	Protein phosphatase 2, regulatory subunit A, beta b.	0.451