STRINGSTRING
rfc5 rfc5 babam2 babam2 rfc2 rfc2 ENSPREP00000003697 ENSPREP00000003697 sumo2 sumo2 ENSPREP00000001588 ENSPREP00000001588 LOC103472958 LOC103472958 ENSPREP00000000287 ENSPREP00000000287 LOC103461674 LOC103461674 kat5 kat5 LOC103474640 LOC103474640 mre11 mre11 ankrd11 ankrd11 ppp4r2 ppp4r2 brca1 brca1 rhno1 rhno1 ENSPREP00000031399 ENSPREP00000031399 ENSPREP00000030473 ENSPREP00000030473 ENSPREP00000029980 ENSPREP00000029980 Brcc3 Brcc3 rmi1 rmi1 ENSPREP00000027944 ENSPREP00000027944 LOC103467542 LOC103467542 LOC103468487 LOC103468487 exo1 exo1 top3a top3a LOC103466094 LOC103466094 ube2i ube2i uimc1 uimc1 LOC103479463 LOC103479463 rad9a rad9a tp53bp1 tp53bp1 rad1 rad1 LOC103467943 LOC103467943 atm atm nbn nbn rad9b rad9b ENSPREP00000023621 ENSPREP00000023621 atrip atrip timeless timeless LOC103475008 LOC103475008 cdk2 cdk2 mdc1 mdc1 rpa3 rpa3 rfc4 rfc4 ENSPREP00000018722 ENSPREP00000018722 babam1 babam1 abraxas1 abraxas1 recql4 recql4 ube2n ube2n ccna1 ccna1 atr atr LOC103475329 LOC103475329 rad17 rad17 rfc3 rfc3 rbbp8 rbbp8 ENSPREP00000015300 ENSPREP00000015300 hus1 hus1 LOC103474198 LOC103474198 Ankrd12 Ankrd12 RPA1 RPA1 dna2 dna2 ENSPREP00000013055 ENSPREP00000013055 ENSPREP00000013045 ENSPREP00000013045 ENSPREP00000012897 ENSPREP00000012897 pias4 pias4 ENSPREP00000012739 ENSPREP00000012739 ube2v2 ube2v2 rnf8 rnf8 tipin tipin rmi2 rmi2 LOC103479695 LOC103479695 RCBTB1 RCBTB1 blm blm ENSPREP00000011248 ENSPREP00000011248 ppp4c ppp4c ccna2 ccna2 ENSPREP00000009961 ENSPREP00000009961 ENSPREP00000009934 ENSPREP00000009934 ENSPREP00000009572 ENSPREP00000009572 ENSPREP00000009489 ENSPREP00000009489 ENSPREP00000009448 ENSPREP00000009448 LOC103458735 LOC103458735 ENSPREP00000009062 ENSPREP00000009062 LOC103458261 LOC103458261 ENSPREP00000008908 ENSPREP00000008908 rad50 rad50 ENSPREP00000008303 ENSPREP00000008303 ENSPREP00000008127 ENSPREP00000008127 ENSPREP00000007980 ENSPREP00000007980 ENSPREP00000007848 ENSPREP00000007848 topbp1 topbp1 ENSPREP00000007704 ENSPREP00000007704 rpa2 rpa2 ENSPREP00000007137 ENSPREP00000007137 ENSPREP00000007029 ENSPREP00000007029
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rfc5Replication factor C (activator 1) 5. (335 aa)
babam2BRISC and BRCA1 A complex member 2. (386 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
ENSPREP00000003697Uncharacterized protein. (168 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
ENSPREP00000001588Ubiquitin-conjugating enzyme E2 variant 1. (146 aa)
LOC103472958Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPREP00000000287Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
LOC103461674Ubiquitin-like domain-containing protein. (161 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
LOC103474640Histone H2A; Belongs to the histone H2A family. (138 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)
ankrd11Ankyrin repeat domain 11. (2822 aa)
ppp4r2Protein phosphatase 4, regulatory subunit 2b. (415 aa)
brca1Uncharacterized protein. (1344 aa)
rhno1Si:ch73-352p4.5. (221 aa)
ENSPREP00000031399Ring finger protein 168. (425 aa)
ENSPREP00000030473Uncharacterized protein. (225 aa)
ENSPREP00000029980Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
Brcc3BRCA1/BRCA2-containing complex, subunit 3. (251 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
ENSPREP00000027944Reverse transcriptase domain-containing protein. (1281 aa)
LOC103467542Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC103468487UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
exo1Exonuclease 1. (757 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1019 aa)
LOC103466094Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (209 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
uimc1Uncharacterized protein. (985 aa)
LOC103479463Sirtuin 6. (339 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (387 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1579 aa)
rad1RAD1 homolog (S. pombe). (279 aa)
LOC103467943Small ubiquitin-related modifier. (96 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
nbnNibrin. (843 aa)
rad9bRAD9 checkpoint clamp component B. (442 aa)
ENSPREP00000023621Uncharacterized protein. (277 aa)
atripUncharacterized protein. (763 aa)
timelessTimeless circadian clock. (1173 aa)
LOC103475008Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
mdc1Uncharacterized protein. (2088 aa)
rpa3Replication protein A3. (122 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
ENSPREP00000018722Reverse transcriptase domain-containing protein. (253 aa)
babam1BRISC and BRCA1 A complex member 1. (355 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (349 aa)
recql4RecQ helicase-like 4. (1237 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (402 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
LOC103475329Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
rad17RAD17 checkpoint clamp loader component. (705 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
rbbp8Uncharacterized protein. (647 aa)
ENSPREP00000015300Reverse transcriptase domain-containing protein. (415 aa)
hus1Checkpoint protein; Belongs to the HUS1 family. (245 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
Ankrd12ANK_REP_REGION domain-containing protein. (423 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
dna2Uncharacterized protein. (1328 aa)
ENSPREP00000013055Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (149 aa)
ENSPREP00000013045Histone H2B; Belongs to the histone H2B family. (157 aa)
ENSPREP00000012897Histone H2B; Belongs to the histone H2B family. (140 aa)
pias4Protein inhibitor of activated STAT, 4a. (509 aa)
ENSPREP00000012739Histone H2B; Belongs to the histone H2B family. (120 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (149 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (490 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (254 aa)
rmi2RecQ mediated genome instability 2. (146 aa)
LOC103479695Histone H2B; Belongs to the histone H2B family. (116 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
blmBLM RecQ like helicase. (1399 aa)
ENSPREP00000011248Histone H2B; Belongs to the histone H2B family. (120 aa)
ppp4cSerine/threonine-protein phosphatase. (330 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
ENSPREP00000009961annotation not available (65 aa)
ENSPREP00000009934Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (65 aa)
ENSPREP00000009572Reverse transcriptase domain-containing protein. (554 aa)
ENSPREP00000009489Zgc:163040. (93 aa)
ENSPREP00000009448Histone H2B; Belongs to the histone H2B family. (110 aa)
LOC103458735Small ubiquitin-related modifier. (94 aa)
ENSPREP00000009062Si:ch211-113a14.22; Belongs to the histone H2B family. (119 aa)
LOC103458261Nuclear receptor binding SET domain protein 2. (472 aa)
ENSPREP00000008908Histone H2B; Belongs to the histone H2B family. (134 aa)
rad50RAD50 homolog, double strand break repair protein. (1355 aa)
ENSPREP00000008303Reverse transcriptase domain-containing protein. (353 aa)
ENSPREP00000008127Reverse transcriptase domain-containing protein. (1242 aa)
ENSPREP00000007980Reverse transcriptase domain-containing protein. (282 aa)
ENSPREP00000007848Histone H2B; Belongs to the histone H2B family. (119 aa)
topbp1DNA topoisomerase II binding protein 1. (1453 aa)
ENSPREP00000007704Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
rpa2Replication protein A2. (256 aa)
ENSPREP00000007137Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPREP00000007029Uncharacterized protein. (115 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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