(24 nodes) Presynaptic phase of homologous DNA pairing and strand exchange network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rad51	RAD51 recombinase. (219 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1355 aa)
	blm	BLM RecQ like helicase. (1399 aa)
	rmi2	RecQ mediated genome instability 2. (146 aa)
	exd2	Exonuclease 3'-5' domain containing 2. (644 aa)
	dna2	Uncharacterized protein. (1328 aa)
	Ankrd12	ANK_REP_REGION domain-containing protein. (423 aa)
	rbbp8	Uncharacterized protein. (647 aa)
	xrcc2	X-ray repair cross complementing 2. (292 aa)
	recql4	RecQ helicase-like 4. (1237 aa)
	brca2	BRCA2 DNA repair associated. (3038 aa)
	rad51c	RAD51 paralog C. (377 aa)
	rad51d	RAD51 paralog D. (350 aa)
	nbn	Nibrin. (843 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	kat5	Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (560 aa)
	chek1	Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
	top3a	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1019 aa)
	exo1	Exonuclease 1. (757 aa)
	rmi1	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (671 aa)
	tdrd3	Tudor domain containing 3. (786 aa)
	brca1	Uncharacterized protein. (1344 aa)
	ankrd11	Ankyrin repeat domain 11. (2822 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (611 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ankrd12	atm	ENSPREP00000015143	ENSPREP00000024388	ANK_REP_REGION domain-containing protein.	Non-specific serine/threonine protein kinase.	0.600
Ankrd12	blm	ENSPREP00000015143	ENSPREP00000011311	ANK_REP_REGION domain-containing protein.	BLM RecQ like helicase.	0.446
Ankrd12	brca1	ENSPREP00000015143	ENSPREP00000033076	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.940
Ankrd12	brca2	ENSPREP00000015143	ENSPREP00000018297	ANK_REP_REGION domain-containing protein.	BRCA2 DNA repair associated.	0.732
Ankrd12	chek1	ENSPREP00000015143	ENSPREP00000025637	ANK_REP_REGION domain-containing protein.	Checkpoint kinase 1; Belongs to the protein kinase superfamily.	0.463
Ankrd12	dna2	ENSPREP00000015143	ENSPREP00000013874	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.585
Ankrd12	exo1	ENSPREP00000015143	ENSPREP00000027206	ANK_REP_REGION domain-containing protein.	Exonuclease 1.	0.571
Ankrd12	mre11	ENSPREP00000015143	ENSPREP00000033509	ANK_REP_REGION domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.847
Ankrd12	nbn	ENSPREP00000015143	ENSPREP00000024347	ANK_REP_REGION domain-containing protein.	Nibrin.	0.830
Ankrd12	rad50	ENSPREP00000015143	ENSPREP00000008829	ANK_REP_REGION domain-containing protein.	RAD50 homolog, double strand break repair protein.	0.747
Ankrd12	rad51	ENSPREP00000015143	ENSPREP00000001621	ANK_REP_REGION domain-containing protein.	RAD51 recombinase.	0.743
Ankrd12	rad51c	ENSPREP00000015143	ENSPREP00000019301	ANK_REP_REGION domain-containing protein.	RAD51 paralog C.	0.620
Ankrd12	rad51d	ENSPREP00000015143	ENSPREP00000020832	ANK_REP_REGION domain-containing protein.	RAD51 paralog D.	0.562
Ankrd12	rbbp8	ENSPREP00000015143	ENSPREP00000015661	ANK_REP_REGION domain-containing protein.	Uncharacterized protein.	0.904
Ankrd12	recql4	ENSPREP00000015143	ENSPREP00000018082	ANK_REP_REGION domain-containing protein.	RecQ helicase-like 4.	0.446
Ankrd12	rmi1	ENSPREP00000015143	ENSPREP00000028254	ANK_REP_REGION domain-containing protein.	RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae).	0.503
Ankrd12	rmi2	ENSPREP00000015143	ENSPREP00000012010	ANK_REP_REGION domain-containing protein.	RecQ mediated genome instability 2.	0.459
Ankrd12	top3a	ENSPREP00000015143	ENSPREP00000026728	ANK_REP_REGION domain-containing protein.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.469
Ankrd12	xrcc2	ENSPREP00000015143	ENSPREP00000015895	ANK_REP_REGION domain-containing protein.	X-ray repair cross complementing 2.	0.551
ankrd11	atm	ENSPREP00000033361	ENSPREP00000024388	Ankyrin repeat domain 11.	Non-specific serine/threonine protein kinase.	0.600