STRINGSTRING
xpa xpa ENSPREP00000001588 ENSPREP00000001588 parp1 parp1 atad5 atad5 actr5 actr5 ppie ppie parp2 parp2 sumo2 sumo2 prpf19 prpf19 cdk7 cdk7 polr2c polr2c ino80b ino80b polk polk polr2i polr2i ccnh ccnh gtf2h5 gtf2h5 ddb1 ddb1 rfc2 rfc2 rfc5 rfc5 pole2 pole2 LOC103474020 LOC103474020 rpa2 rpa2 ENSPREP00000008014 ENSPREP00000008014 ENSPREP00000008026 ENSPREP00000008026 Wbp1 Wbp1 xab2 xab2 ino80d ino80d gps1 gps1 LOC103458735 LOC103458735 LOC103474795 LOC103474795 usp40 usp40 POLR2E POLR2E LOC103471875 LOC103471875 ubb ubb ENSPREP00000009964 ENSPREP00000009964 aqr aqr polr2h polr2h rfc1 rfc1 tfpt tfpt RCBTB1 RCBTB1 LOC103462108 LOC103462108 LOC103478445 LOC103478445 ube2v2 ube2v2 cops2 cops2 ENSPREP00000012814 ENSPREP00000012814 nrde2 nrde2 LOC103461674 LOC103461674 ZNF830 ZNF830 wdr76 wdr76 pole3 pole3 parp3 parp3 meiob meiob YY1 YY1 xrcc1 xrcc1 LOC103458892 LOC103458892 vwa5b2 vwa5b2 rpap3 rpap3 tcea1 tcea1 ercc4 ercc4 LOC103467943 LOC103467943 polr2g polr2g ENSPREP00000024644 ENSPREP00000024644 ENSPREP00000024682 ENSPREP00000024682 polr2f polr2f RAD23B RAD23B LOC103470792 LOC103470792 LOC103470791 LOC103470791 bivm bivm ENSPREP00000025259 ENSPREP00000025259 ercc8 ercc8 ube2i ube2i rbx1 rbx1 chd1l chd1l LOC103466094 LOC103466094 LOC103468460 LOC103468460 cops4 cops4 actb actb LOC103468487 LOC103468487 ino80c ino80c ercc2 ercc2 nfrkb nfrkb LOC103467918 LOC103467918 pold2 pold2 pold3 pold3 usp7 usp7 gtf2h4 gtf2h4 lig1 lig1 ppp1r42 ppp1r42 cops5 cops5 gtf2h3 gtf2h3 LOC103482005 LOC103482005 ercc3 ercc3 ercc6 ercc6 cul4a cul4a cops3 cops3 ercc5 ercc5 polr2d polr2d hmgn5 hmgn5 LOC103470988 LOC103470988 phf3 phf3 POLE POLE ENSPREP00000033302 ENSPREP00000033302 pold4 pold4 polr2l polr2l actr8 actr8 rnf111 rnf111 RPA1 RPA1 LOC103474198 LOC103474198 LOC103476136 LOC103476136 ercc1 ercc1 LOC103466533 LOC103466533 rfc3 rfc3 LOC103475329 LOC103475329 ddb2 ddb2 polr2b polr2b uba52 uba52 tceanc2 tceanc2 ENSPREP00000017501 ENSPREP00000017501 ENSPREP00000017515 ENSPREP00000017515 cul4b cul4b ube2n ube2n LOC103470674 LOC103470674 pcna pcna ruvbl1 ruvbl1 rps27a rps27a Tceanc Tceanc cops7a cops7a rfc4 rfc4 LOC103463524 LOC103463524 Rad23a Rad23a pole4 pole4 rpa3 rpa3 polr2a polr2a ino80e ino80e xpc xpc gtf2h1 gtf2h1 kctd2 kctd2 ino80 ino80 cetn3 cetn3 pold1 pold1 COPS6 COPS6 ENSPREP00000020872 ENSPREP00000020872 lig3 lig3 LOC103473189 LOC103473189 LOC103475008 LOC103475008 mcrs1 mcrs1 LOC103480949 LOC103480949 sumo1 sumo1 ENSPREP00000022268 ENSPREP00000022268 LOC103460347 LOC103460347 polr2j polr2j mnat1 mnat1 usp45 usp45 LOC103462148 LOC103462148
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xpaXeroderma pigmentosum, complementation group A. (275 aa)
ENSPREP00000001588Ubiquitin-conjugating enzyme E2 variant 1. (146 aa)
parp1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)
atad5ATPase family AAA domain containing 5a. (1822 aa)
actr5Actin related protein 5; Belongs to the actin family. (624 aa)
ppiePeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
parp2Poly [ADP-ribose] polymerase. (647 aa)
sumo2Small ubiquitin-related modifier. (95 aa)
prpf19Pre-mRNA processing factor 19. (458 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (387 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (273 aa)
ino80bINO80 complex subunit B. (339 aa)
polkPolymerase (DNA directed) kappa. (880 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
ddb1Damage-specific DNA binding protein 1. (1102 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
LOC103474020Uncharacterized protein; Belongs to the actin family. (382 aa)
rpa2Replication protein A2. (256 aa)
ENSPREP00000008014Uncharacterized protein; Belongs to the actin family. (180 aa)
ENSPREP00000008026Uncharacterized protein. (143 aa)
Wbp1Uncharacterized protein. (460 aa)
xab2XPA binding protein 2. (912 aa)
ino80dINO80 complex subunit Da. (1025 aa)
gps1G protein pathway suppressor 1. (486 aa)
LOC103458735Small ubiquitin-related modifier. (94 aa)
LOC103474795Uncharacterized protein. (762 aa)
usp40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1293 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
LOC103471875Centrin 4. (171 aa)
ubbUncharacterized protein. (179 aa)
ENSPREP00000009964Ubiquitin-like domain-containing protein. (95 aa)
aqrAquarius intron-binding spliceosomal factor. (1325 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
rfc1Replication factor C subunit 1. (1090 aa)
tfptTCF3 (E2A) fusion partner. (199 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC103462108Protein inhibitor of activated STAT, 1a. (658 aa)
LOC103478445Transcription elongation factor A (SII), 3. (562 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (149 aa)
cops2COP9 signalosome subunit 2. (448 aa)
ENSPREP00000012814Uncharacterized protein. (74 aa)
nrde2NRDE-2, necessary for RNA interference, domain containing. (1204 aa)
LOC103461674Ubiquitin-like domain-containing protein. (161 aa)
ZNF830Zinc finger protein 830. (333 aa)
wdr76WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (535 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
parp3Poly [ADP-ribose] polymerase. (522 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
YY1YY1 transcription factor b. (372 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
LOC103458892YY1 transcription factor. (348 aa)
vwa5b2Von Willebrand factor A domain containing 5B2. (1248 aa)
rpap3RNA polymerase II associated protein 3. (639 aa)
tcea1Transcription elongation factor A (SII), 1. (320 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
LOC103467943Small ubiquitin-related modifier. (96 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
ENSPREP00000024644Si:cabz01080528.1. (583 aa)
ENSPREP00000024682KxDL motif containing 1. (197 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (98 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (421 aa)
LOC103470792Uncharacterized protein. (400 aa)
LOC103470791Uncharacterized protein. (372 aa)
bivmBasic, immunoglobulin-like variable motif containing. (500 aa)
ENSPREP00000025259Uncharacterized protein; Belongs to the actin family. (240 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
ube2iUbiquitin-conjugating enzyme E2Ib; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
chd1lChromodomain helicase DNA binding protein 1-like. (867 aa)
LOC103466094Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (209 aa)
LOC103468460E1A binding protein p300 b. (2737 aa)
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (406 aa)
actbUncharacterized protein. (375 aa)
LOC103468487UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
ino80cINO80 complex subunit C. (205 aa)
ercc2Excision repair cross-complementation group 2. (655 aa)
nfrkbNuclear factor related to kappaB binding protein. (1283 aa)
LOC103467918Transcription elongation factor A (SII), 2. (369 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1186 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (434 aa)
lig1DNA ligase. (1002 aa)
ppp1r42Protein phosphatase 1, regulatory subunit 42. (291 aa)
cops5COP9 signalosome subunit 5. (338 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (277 aa)
LOC103482005E1A binding protein p300 a. (2743 aa)
ercc3Excision repair cross-complementation group 3. (783 aa)
ercc6Excision repair cross-complementation group 6. (1402 aa)
cul4aCullin 4A; Belongs to the cullin family. (591 aa)
cops3COP9 signalosome subunit 3. (423 aa)
ercc5Excision repair cross-complementation group 5. (980 aa)
polr2dPolymerase (RNA) II (DNA directed) polypeptide D. (104 aa)
hmgn5High mobility group nucleosome binding domain 6. (81 aa)
LOC103470988UV-stimulated scaffold protein A. (688 aa)
phf3PHD finger protein 3. (1640 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
ENSPREP00000033302DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
pold4Uncharacterized protein. (89 aa)
polr2lPolymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
actr8Actin-related protein 8; Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize; Belongs to the actin family. ARP8 subfamily. (644 aa)
rnf111Ring finger protein 111. (982 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
LOC103476136Si:ch73-1a9.3. (82 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
LOC103466533Protein inhibitor of activated STAT, 1b. (647 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC103475329Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
ddb2Damage-specific DNA binding protein 2. (490 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
tceanc2Uncharacterized protein. (206 aa)
ENSPREP00000017501Rad60-SLD domain-containing protein. (78 aa)
ENSPREP00000017515Uncharacterized protein. (289 aa)
cul4bCullin 4B; Belongs to the cullin family. (872 aa)
ube2nUBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (153 aa)
LOC103470674General transcription factor IIH subunit. (420 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
rps27aRibosomal protein S27a. (156 aa)
TceancUncharacterized protein. (355 aa)
cops7aCOP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC103463524SCY domain-containing protein. (192 aa)
Rad23aUbiquitin-like domain-containing protein. (168 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
rpa3Replication protein A3. (122 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
ino80eINO80 complex subunit E. (211 aa)
xpcXeroderma pigmentosum, complementation group C. (852 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (550 aa)
kctd2Potassium channel tetramerization domain containing 2. (268 aa)
ino80INO80 complex ATPase subunit. (1484 aa)
cetn3Uncharacterized protein. (198 aa)
pold1DNA polymerase. (1102 aa)
COPS6COP9 signalosome subunit 6. (316 aa)
ENSPREP00000020872Uncharacterized protein. (76 aa)
lig3DNA ligase. (997 aa)
LOC103473189Uncharacterized protein. (154 aa)
LOC103475008Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
mcrs1Microspherule protein 1. (474 aa)
LOC103480949Si:ch73-290k24.6. (746 aa)
sumo1Small ubiquitin like modifier 1. (205 aa)
ENSPREP00000022268VIT domain-containing protein. (173 aa)
LOC103460347ISY1 splicing factor homolog. (235 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
usp45Ubiquitin carboxyl-terminal hydrolase. (821 aa)
LOC103462148Uncharacterized protein. (375 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
Server load: low (26%) [HD]