50 items (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	parp2	Poly [ADP-ribose] polymerase. (647 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	LOC103475329	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	ddb2	Damage-specific DNA binding protein 2. (490 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (872 aa)
	LOC103470674	General transcription factor IIH subunit. (420 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
	rpa3	Replication protein A3. (122 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	pold1	DNA polymerase. (1102 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	LOC103475008	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
	ercc4	Excision repair cross-complementation group 4. (893 aa)
	ENSPREP00000024682	KxDL motif containing 1. (197 aa)
	bivm	Basic, immunoglobulin-like variable motif containing. (500 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	chd1l	Chromodomain helicase DNA binding protein 1-like. (867 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	rpa2	Replication protein A2. (256 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	polk	Polymerase (DNA directed) kappa. (880 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ddb1	Damage-specific DNA binding protein 1. (1102 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (434 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (277 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (591 aa)
	ercc5	Excision repair cross-complementation group 5. (980 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
	ENSPREP00000033302	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
	pold4	Uncharacterized protein. (89 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	rfc1	Replication factor C subunit 1. (1090 aa)
	ENSPREP00000009964	Ubiquitin-like domain-containing protein. (95 aa)
	ubb	Uncharacterized protein. (179 aa)
	ercc1	Excision repair cross-complementation group 1. (358 aa)
	LOC103474198	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	parp3	Poly [ADP-ribose] polymerase. (522 aa)
	xpa	Xeroderma pigmentosum, complementation group A. (275 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1015 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009964	ENSPREP00000024682	ENSPREP00000009964	ENSPREP00000024682	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.594
ENSPREP00000009964	ENSPREP00000033302	ENSPREP00000009964	ENSPREP00000033302	Ubiquitin-like domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.488
ENSPREP00000009964	LOC103470674	ENSPREP00000009964	ENSPREP00000017962	Ubiquitin-like domain-containing protein.	General transcription factor IIH subunit.	0.602
ENSPREP00000009964	LOC103474198	ENSPREP00000009964	ENSPREP00000015219	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.423
ENSPREP00000009964	POLE	ENSPREP00000009964	ENSPREP00000033293	Ubiquitin-like domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.488
ENSPREP00000009964	RPA1	ENSPREP00000009964	ENSPREP00000014993	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.423
ENSPREP00000009964	bivm	ENSPREP00000009964	ENSPREP00000025122	Ubiquitin-like domain-containing protein.	Basic, immunoglobulin-like variable motif containing.	0.464
ENSPREP00000009964	chd1l	ENSPREP00000009964	ENSPREP00000026478	Ubiquitin-like domain-containing protein.	Chromodomain helicase DNA binding protein 1-like.	0.569
ENSPREP00000009964	cul4a	ENSPREP00000009964	ENSPREP00000031714	Ubiquitin-like domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.602
ENSPREP00000009964	cul4b	ENSPREP00000009964	ENSPREP00000017778	Ubiquitin-like domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.602
ENSPREP00000009964	ddb1	ENSPREP00000009964	ENSPREP00000006475	Ubiquitin-like domain-containing protein.	Damage-specific DNA binding protein 1.	0.701
ENSPREP00000009964	ddb2	ENSPREP00000009964	ENSPREP00000016461	Ubiquitin-like domain-containing protein.	Damage-specific DNA binding protein 2.	0.581
ENSPREP00000009964	ercc1	ENSPREP00000009964	ENSPREP00000015481	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 1.	0.575
ENSPREP00000009964	ercc2	ENSPREP00000009964	ENSPREP00000028527	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 2.	0.606
ENSPREP00000009964	ercc3	ENSPREP00000009964	ENSPREP00000030919	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 3.	0.658
ENSPREP00000009964	ercc4	ENSPREP00000009964	ENSPREP00000024474	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 4.	0.565
ENSPREP00000009964	ercc5	ENSPREP00000009964	ENSPREP00000032160	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 5.	0.464
ENSPREP00000009964	gtf2h1	ENSPREP00000009964	ENSPREP00000019946	Ubiquitin-like domain-containing protein.	General transcription factor IIH, polypeptide 1.	0.627
ENSPREP00000009964	gtf2h3	ENSPREP00000009964	ENSPREP00000030691	Ubiquitin-like domain-containing protein.	General transcription factor IIH, polypeptide 3.	0.636
ENSPREP00000009964	gtf2h4	ENSPREP00000009964	ENSPREP00000029112	Ubiquitin-like domain-containing protein.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.520