STRINGSTRING
LOC103474198 LOC103474198 LOC103470674 LOC103470674 pcna pcna rps27a rps27a Tceanc Tceanc cops7a cops7a rfc4 rfc4 LOC103463524 LOC103463524 pole4 pole4 rpa3 rpa3 polr2a polr2a gtf2h1 gtf2h1 pold1 pold1 COPS6 COPS6 ENSPREP00000020872 ENSPREP00000020872 lig3 lig3 LOC103473189 LOC103473189 LOC103475008 LOC103475008 LOC103460347 LOC103460347 polr2j polr2j mnat1 mnat1 meiob meiob xrcc1 xrcc1 tcea1 tcea1 ercc4 ercc4 polr2g polr2g ENSPREP00000024682 ENSPREP00000024682 polr2f polr2f bivm bivm ercc8 ercc8 rbx1 rbx1 LOC103468460 LOC103468460 cops4 cops4 ercc2 ercc2 LOC103467918 LOC103467918 pold3 pold3 usp7 usp7 gtf2h4 gtf2h4 lig1 lig1 ppp1r42 ppp1r42 cops5 cops5 gtf2h3 gtf2h3 LOC103482005 LOC103482005 ercc3 ercc3 ercc6 ercc6 cul4a cul4a cops3 cops3 ercc5 ercc5 xpa xpa atad5 atad5 ppie ppie prpf19 prpf19 cdk7 cdk7 polr2c polr2c polk polk polr2i polr2i ccnh ccnh gtf2h5 gtf2h5 ddb1 ddb1 rfc2 rfc2 rfc5 rfc5 pole2 pole2 rpa2 rpa2 xab2 xab2 gps1 gps1 usp40 usp40 POLR2E POLR2E ubb ubb ENSPREP00000009964 ENSPREP00000009964 aqr aqr polr2h polr2h rfc1 rfc1 RCBTB1 RCBTB1 LOC103478445 LOC103478445 cops2 cops2 ENSPREP00000012814 ENSPREP00000012814 nrde2 nrde2 ZNF830 ZNF830 pole3 pole3 pold2 pold2 RPA1 RPA1 LOC103476136 LOC103476136 ercc1 ercc1 rfc3 rfc3 LOC103475329 LOC103475329 polr2b polr2b uba52 uba52 tceanc2 tceanc2 cul4b cul4b polr2d polr2d hmgn5 hmgn5 LOC103470988 LOC103470988 phf3 phf3 POLE POLE ENSPREP00000033302 ENSPREP00000033302 pold4 pold4 polr2l polr2l
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
LOC103470674General transcription factor IIH subunit. (420 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
rps27aRibosomal protein S27a. (156 aa)
TceancUncharacterized protein. (355 aa)
cops7aCOP9 constitutive photomorphogenic homolog subunit 7A. (268 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
LOC103463524SCY domain-containing protein. (192 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
rpa3Replication protein A3. (122 aa)
polr2aDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
gtf2h1General transcription factor IIH, polypeptide 1. (550 aa)
pold1DNA polymerase. (1102 aa)
COPS6COP9 signalosome subunit 6. (316 aa)
ENSPREP00000020872Uncharacterized protein. (76 aa)
lig3DNA ligase. (997 aa)
LOC103473189Uncharacterized protein. (154 aa)
LOC103475008Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
LOC103460347ISY1 splicing factor homolog. (235 aa)
polr2jPolymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
mnat1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
xrcc1X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
tcea1Transcription elongation factor A (SII), 1. (320 aa)
ercc4Excision repair cross-complementation group 4. (893 aa)
polr2gPolymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
ENSPREP00000024682KxDL motif containing 1. (197 aa)
polr2fPolymerase (RNA) II (DNA directed) polypeptide F. (98 aa)
bivmBasic, immunoglobulin-like variable motif containing. (500 aa)
ercc8Excision repair cross-complementation group 8. (401 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC103468460E1A binding protein p300 b. (2737 aa)
cops4COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis). (406 aa)
ercc2Excision repair cross-complementation group 2. (655 aa)
LOC103467918Transcription elongation factor A (SII), 2. (369 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
usp7Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1186 aa)
gtf2h4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (434 aa)
lig1DNA ligase. (1002 aa)
ppp1r42Protein phosphatase 1, regulatory subunit 42. (291 aa)
cops5COP9 signalosome subunit 5. (338 aa)
gtf2h3General transcription factor IIH, polypeptide 3. (277 aa)
LOC103482005E1A binding protein p300 a. (2743 aa)
ercc3Excision repair cross-complementation group 3. (783 aa)
ercc6Excision repair cross-complementation group 6. (1402 aa)
cul4aCullin 4A; Belongs to the cullin family. (591 aa)
cops3COP9 signalosome subunit 3. (423 aa)
ercc5Excision repair cross-complementation group 5. (980 aa)
xpaXeroderma pigmentosum, complementation group A. (275 aa)
atad5ATPase family AAA domain containing 5a. (1822 aa)
ppiePeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
prpf19Pre-mRNA processing factor 19. (458 aa)
cdk7Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (387 aa)
polr2cPolymerase (RNA) II (DNA directed) polypeptide C. (273 aa)
polkPolymerase (DNA directed) kappa. (880 aa)
polr2iDNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
gtf2h5General transcription factor IIH, polypeptide 5. (71 aa)
ddb1Damage-specific DNA binding protein 1. (1102 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
rpa2Replication protein A2. (256 aa)
xab2XPA binding protein 2. (912 aa)
gps1G protein pathway suppressor 1. (486 aa)
usp40Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1293 aa)
POLR2ERNA polymerase II subunit E. (210 aa)
ubbUncharacterized protein. (179 aa)
ENSPREP00000009964Ubiquitin-like domain-containing protein. (95 aa)
aqrAquarius intron-binding spliceosomal factor. (1325 aa)
polr2hDNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
rfc1Replication factor C subunit 1. (1090 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC103478445Transcription elongation factor A (SII), 3. (562 aa)
cops2COP9 signalosome subunit 2. (448 aa)
ENSPREP00000012814Uncharacterized protein. (74 aa)
nrde2NRDE-2, necessary for RNA interference, domain containing. (1204 aa)
ZNF830Zinc finger protein 830. (333 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103476136Si:ch73-1a9.3. (82 aa)
ercc1Excision repair cross-complementation group 1. (358 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC103475329Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
polr2bDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
tceanc2Uncharacterized protein. (206 aa)
cul4bCullin 4B; Belongs to the cullin family. (872 aa)
polr2dPolymerase (RNA) II (DNA directed) polypeptide D. (104 aa)
hmgn5High mobility group nucleosome binding domain 6. (81 aa)
LOC103470988UV-stimulated scaffold protein A. (688 aa)
phf3PHD finger protein 3. (1640 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
ENSPREP00000033302DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
pold4Uncharacterized protein. (89 aa)
polr2lPolymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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