82 items (Poecilia reticulata) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	ZNF830	Zinc finger protein 830. (333 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (173 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
	RPA1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
	LOC103474198	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
	LOC103476136	Si:ch73-1a9.3. (82 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	LOC103475329	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
	polr2b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1174 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	tceanc2	Uncharacterized protein. (206 aa)
	cul4b	Cullin 4B; Belongs to the cullin family. (872 aa)
	LOC103470674	General transcription factor IIH subunit. (420 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	Tceanc	Uncharacterized protein. (355 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (145 aa)
	rpa3	Replication protein A3. (122 aa)
	polr2a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1966 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	pold1	DNA polymerase. (1102 aa)
	lig3	DNA ligase. (997 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	LOC103475008	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
	LOC103460347	ISY1 splicing factor homolog. (235 aa)
	polr2j	Polymerase (RNA) II (DNA directed) polypeptide J. (117 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	meiob	Methionine sulfoxide reductase B1b. (464 aa)
	xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (619 aa)
	tcea1	Transcription elongation factor A (SII), 1. (320 aa)
	polr2g	Polymerase (RNA) II (DNA directed) polypeptide G-like. (172 aa)
	ENSPREP00000024682	KxDL motif containing 1. (197 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (98 aa)
	ercc8	Excision repair cross-complementation group 8. (401 aa)
	rbx1	Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
	LOC103468460	E1A binding protein p300 b. (2737 aa)
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	LOC103467918	Transcription elongation factor A (SII), 2. (369 aa)
	nrde2	NRDE-2, necessary for RNA interference, domain containing. (1204 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1186 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (434 aa)
	lig1	DNA ligase. (1002 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (277 aa)
	LOC103482005	E1A binding protein p300 a. (2743 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	cul4a	Cullin 4A; Belongs to the cullin family. (591 aa)
	polr2d	Polymerase (RNA) II (DNA directed) polypeptide D. (104 aa)
	hmgn5	High mobility group nucleosome binding domain 6. (81 aa)
	LOC103470988	UV-stimulated scaffold protein A. (688 aa)
	phf3	PHD finger protein 3. (1640 aa)
	POLE	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (1114 aa)
	ENSPREP00000033302	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (361 aa)
	pold4	Uncharacterized protein. (89 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	atad5	ATPase family AAA domain containing 5a. (1822 aa)
	ppie	Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (301 aa)
	prpf19	Pre-mRNA processing factor 19. (458 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (387 aa)
	polr2c	Polymerase (RNA) II (DNA directed) polypeptide C. (273 aa)
	polk	Polymerase (DNA directed) kappa. (880 aa)
	polr2i	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (126 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ddb1	Damage-specific DNA binding protein 1. (1102 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	rpa2	Replication protein A2. (256 aa)
	xab2	XPA binding protein 2. (912 aa)
	usp40	Ubiquitin specific peptidase 40; Belongs to the peptidase C19 family. (1293 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	ubb	Uncharacterized protein. (179 aa)
	ENSPREP00000009964	Ubiquitin-like domain-containing protein. (95 aa)
	aqr	Aquarius intron-binding spliceosomal factor. (1325 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	rfc1	Replication factor C subunit 1. (1090 aa)
	RCBTB1	RCC1 and BTB domain containing protein 1. (531 aa)
	LOC103478445	Transcription elongation factor A (SII), 3. (562 aa)
	ENSPREP00000012814	Uncharacterized protein. (74 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000009964	ENSPREP00000012814	ENSPREP00000009964	ENSPREP00000012814	Ubiquitin-like domain-containing protein.	Uncharacterized protein.	0.603
ENSPREP00000009964	ENSPREP00000024682	ENSPREP00000009964	ENSPREP00000024682	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.594
ENSPREP00000009964	ENSPREP00000033302	ENSPREP00000009964	ENSPREP00000033302	Ubiquitin-like domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.488
ENSPREP00000009964	LOC103468460	ENSPREP00000009964	ENSPREP00000026558	Ubiquitin-like domain-containing protein.	E1A binding protein p300 b.	0.448
ENSPREP00000009964	LOC103470674	ENSPREP00000009964	ENSPREP00000017962	Ubiquitin-like domain-containing protein.	General transcription factor IIH subunit.	0.602
ENSPREP00000009964	LOC103474198	ENSPREP00000009964	ENSPREP00000015219	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.423
ENSPREP00000009964	LOC103482005	ENSPREP00000009964	ENSPREP00000030842	Ubiquitin-like domain-containing protein.	E1A binding protein p300 a.	0.448
ENSPREP00000009964	POLE	ENSPREP00000009964	ENSPREP00000033293	Ubiquitin-like domain-containing protein.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.488
ENSPREP00000009964	POLR2E	ENSPREP00000009964	ENSPREP00000009571	Ubiquitin-like domain-containing protein.	RNA polymerase II subunit E.	0.602
ENSPREP00000009964	RPA1	ENSPREP00000009964	ENSPREP00000014993	Ubiquitin-like domain-containing protein.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.423
ENSPREP00000009964	atad5	ENSPREP00000009964	ENSPREP00000001791	Ubiquitin-like domain-containing protein.	ATPase family AAA domain containing 5a.	0.407
ENSPREP00000009964	ccnh	ENSPREP00000009964	ENSPREP00000006353	Ubiquitin-like domain-containing protein.	Cyclin H; Belongs to the cyclin family.	0.560
ENSPREP00000009964	cdk7	ENSPREP00000009964	ENSPREP00000003727	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.459
ENSPREP00000009964	cul4a	ENSPREP00000009964	ENSPREP00000031714	Ubiquitin-like domain-containing protein.	Cullin 4A; Belongs to the cullin family.	0.602
ENSPREP00000009964	cul4b	ENSPREP00000009964	ENSPREP00000017778	Ubiquitin-like domain-containing protein.	Cullin 4B; Belongs to the cullin family.	0.602
ENSPREP00000009964	ddb1	ENSPREP00000009964	ENSPREP00000006475	Ubiquitin-like domain-containing protein.	Damage-specific DNA binding protein 1.	0.701
ENSPREP00000009964	ercc2	ENSPREP00000009964	ENSPREP00000028527	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 2.	0.606
ENSPREP00000009964	ercc3	ENSPREP00000009964	ENSPREP00000030919	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 3.	0.658
ENSPREP00000009964	ercc6	ENSPREP00000009964	ENSPREP00000031633	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 6.	0.785
ENSPREP00000009964	ercc8	ENSPREP00000009964	ENSPREP00000026087	Ubiquitin-like domain-containing protein.	Excision repair cross-complementation group 8.	0.548