(40 nodes) Regulation of TP53 Degradation network (Poecilia reticulata)

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Predicted Interactions

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Your Input:
	ENSPREP00000016378	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family. (702 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
	cdk2	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	LOC103473189	Uncharacterized protein. (154 aa)
	LOC103476332	Ubiquitin carboxyl-terminal hydrolase. (399 aa)
	chek2	Checkpoint kinase 2. (510 aa)
	atm	Non-specific serine/threonine protein kinase. (3091 aa)
	ENSPREP00000024682	KxDL motif containing 1. (197 aa)
	ppp2cb	Serine/threonine-protein phosphatase. (304 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (538 aa)
	usp7	Ubiquitin specific peptidase 7 (herpes virus-associated); Belongs to the peptidase C19 family. (1186 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	mdm2	MDM2 proto-oncogene. (434 aa)
	Phf20	Uncharacterized protein. (94 aa)
	ppp2r1b	Protein phosphatase 2, regulatory subunit A, beta b. (613 aa)
	ENSPREP00000006739	Uncharacterized protein. (103 aa)
	ppp2ca	Serine/threonine-protein phosphatase. (309 aa)
	ccng1	CYCLIN domain-containing protein; Belongs to the cyclin family. (297 aa)
	ENSPREP00000009964	Ubiquitin-like domain-containing protein. (95 aa)
	ubb	Uncharacterized protein. (179 aa)
	LOC103471193	Serine/threonine-protein phosphatase. (309 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	mdm4	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family. (490 aa)
	rffl	Ring finger and FYVE-like domain containing E3 ubiquitin protein ligase. (342 aa)
	txndc11	Thioredoxin domain containing 11. (894 aa)
	cdk1	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (308 aa)
	ccna2	Cyclin A2; Belongs to the cyclin family. (434 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	rictor	RPTOR independent companion of MTOR, complex 2 a. (1760 aa)
	LOC103470611	Ring finger protein 34a. (520 aa)
	LOC103459277	Uncharacterized protein. (416 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	SGK1	Non-specific serine/threonine protein kinase. (623 aa)
	LOC103474949	Ubiquitin carboxyl-terminal hydrolase. (634 aa)
	LOC103473722	Ring finger protein 34b. (365 aa)
	ccna1	Cyclin A1; Belongs to the cyclin family. (402 aa)
	mapkap1	MAPK associated protein 1. (525 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000006739	LOC103470003	ENSPREP00000006739	ENSPREP00000030956	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.445
ENSPREP00000006739	LOC103474789	ENSPREP00000006739	ENSPREP00000008269	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.445
ENSPREP00000006739	LOC103476681	ENSPREP00000006739	ENSPREP00000012589	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.445
ENSPREP00000006739	akt1	ENSPREP00000006739	ENSPREP00000031683	Uncharacterized protein.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.445
ENSPREP00000006739	mdm2	ENSPREP00000006739	ENSPREP00000032347	Uncharacterized protein.	MDM2 proto-oncogene.	0.500
ENSPREP00000006739	mdm4	ENSPREP00000006739	ENSPREP00000004787	Uncharacterized protein.	MDM4 regulator of p53; Belongs to the MDM2/MDM4 family.	0.500
ENSPREP00000006739	tp53	ENSPREP00000006739	ENSPREP00000019676	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.752
ENSPREP00000009964	ENSPREP00000016378	ENSPREP00000009964	ENSPREP00000016378	Ubiquitin-like domain-containing protein.	Mechanistic target of rapamycin kinase; Belongs to the PI3/PI4-kinase family.	0.696
ENSPREP00000009964	ENSPREP00000024682	ENSPREP00000009964	ENSPREP00000024682	Ubiquitin-like domain-containing protein.	KxDL motif containing 1.	0.594
ENSPREP00000009964	LOC103471193	ENSPREP00000009964	ENSPREP00000008533	Ubiquitin-like domain-containing protein.	Serine/threonine-protein phosphatase.	0.458
ENSPREP00000009964	LOC103474949	ENSPREP00000009964	ENSPREP00000016737	Ubiquitin-like domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.719
ENSPREP00000009964	LOC103476332	ENSPREP00000009964	ENSPREP00000023731	Ubiquitin-like domain-containing protein.	Ubiquitin carboxyl-terminal hydrolase.	0.719
ENSPREP00000009964	Mtor	ENSPREP00000009964	ENSPREP00000016474	Ubiquitin-like domain-containing protein.	Serine/threonine-protein kinase TOR.	0.696
ENSPREP00000009964	atm	ENSPREP00000009964	ENSPREP00000024388	Ubiquitin-like domain-containing protein.	Non-specific serine/threonine protein kinase.	0.574
ENSPREP00000009964	ccna1	ENSPREP00000009964	ENSPREP00000016983	Ubiquitin-like domain-containing protein.	Cyclin A1; Belongs to the cyclin family.	0.611
ENSPREP00000009964	ccna2	ENSPREP00000009964	ENSPREP00000010495	Ubiquitin-like domain-containing protein.	Cyclin A2; Belongs to the cyclin family.	0.611
ENSPREP00000009964	cdk1	ENSPREP00000009964	ENSPREP00000010273	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily.	0.497
ENSPREP00000009964	cdk2	ENSPREP00000009964	ENSPREP00000021129	Ubiquitin-like domain-containing protein.	Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily.	0.497
ENSPREP00000009964	chek2	ENSPREP00000009964	ENSPREP00000024020	Ubiquitin-like domain-containing protein.	Checkpoint kinase 2.	0.433
ENSPREP00000009964	mdm2	ENSPREP00000009964	ENSPREP00000032347	Ubiquitin-like domain-containing protein.	MDM2 proto-oncogene.	0.694