(34 nodes) Pyruvate metabolism network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103466147	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (332 aa)
	LOC103475424	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	ppard	Peroxisome proliferator-activated receptor delta b. (401 aa)
	Mpc1	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (93 aa)
	LOC103460857	PNKD metallo-beta-lactamase domain containing. (360 aa)
	pdk3	Protein-serine/threonine kinase. (404 aa)
	LOC103481842	Protein-serine/threonine kinase. (385 aa)
	ldhb	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (334 aa)
	pdha1	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (400 aa)
	gstz1	Glutathione S-transferase zeta 1; Belongs to the GST superfamily. (273 aa)
	mpc2	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (123 aa)
	ENSPREP00000014189	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (202 aa)
	LOC103465809	L-lactate dehydrogenase; Belongs to the LDH/MDH superfamily. (355 aa)
	fam114a1	Family with sequence similarity 114 member A1. (555 aa)
	LOC103460042	Protein-serine/threonine kinase. (410 aa)
	HAGHL	Hydroxyacylglutathione hydrolase like. (290 aa)
	hagh	Hydroxyacylglutathione hydrolase. (309 aa)
	mblac2	Metallo-beta-lactamase domain containing 2. (276 aa)
	pdk1	Protein-serine/threonine kinase. (460 aa)
	pdpr	Pyruvate dehydrogenase phosphatase regulatory subunit. (892 aa)
	GLO1	Lactoylglutathione lyase; Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. (201 aa)
	vdac1	Voltage-dependent anion channel 1. (258 aa)
	dld	Dihydrolipoyl dehydrogenase. (508 aa)
	LOC103478929	Si:ch73-71c20.5. (138 aa)
	LOC103466019	Putative pyruvate dehydrogenase phosphatase isoenzyme 2. (527 aa)
	ENSPREP00000022378	Si:ch211-15p9.2. (508 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
	pdp1	Pyruvate dehyrogenase phosphatase catalytic subunit 1. (580 aa)
	LACTB2	Lactamase beta 2. (318 aa)
	LOC103472117	Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
	pdhx	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	LOC103472118	Glutathione S-transferase rho; Belongs to the GST superfamily. (215 aa)
	LOC103475425	Uncharacterized protein. (609 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000014189	ENSPREP00000022378	ENSPREP00000014189	ENSPREP00000022378	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Si:ch211-15p9.2.	0.723
ENSPREP00000014189	LOC103460042	ENSPREP00000014189	ENSPREP00000009003	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Protein-serine/threonine kinase.	0.737
ENSPREP00000014189	LOC103466019	ENSPREP00000014189	ENSPREP00000021659	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Putative pyruvate dehydrogenase phosphatase isoenzyme 2.	0.723
ENSPREP00000014189	LOC103475424	ENSPREP00000014189	ENSPREP00000029554	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	LOC103475425	ENSPREP00000014189	ENSPREP00000029465	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Uncharacterized protein.	0.986
ENSPREP00000014189	LOC103481842	ENSPREP00000014189	ENSPREP00000018958	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Protein-serine/threonine kinase.	0.737
ENSPREP00000014189	Rxra	ENSPREP00000014189	ENSPREP00000032811	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Retinoid X receptor, alpha a.	0.505
ENSPREP00000014189	dlat	ENSPREP00000014189	ENSPREP00000026249	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	dld	ENSPREP00000014189	ENSPREP00000003162	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoyl dehydrogenase.	0.999
ENSPREP00000014189	mpc2	ENSPREP00000014189	ENSPREP00000014825	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.	0.517
ENSPREP00000014189	pdha1	ENSPREP00000014189	ENSPREP00000016736	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
ENSPREP00000014189	pdhx	ENSPREP00000014189	ENSPREP00000028190	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.998
ENSPREP00000014189	pdk1	ENSPREP00000014189	ENSPREP00000007123	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Protein-serine/threonine kinase.	0.737
ENSPREP00000014189	pdk3	ENSPREP00000014189	ENSPREP00000021233	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Protein-serine/threonine kinase.	0.745
ENSPREP00000014189	pdp1	ENSPREP00000014189	ENSPREP00000027343	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehyrogenase phosphatase catalytic subunit 1.	0.723
ENSPREP00000014189	pdpr	ENSPREP00000014189	ENSPREP00000006852	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase phosphatase regulatory subunit.	0.615
ENSPREP00000014189	ppard	ENSPREP00000014189	ENSPREP00000033397	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Peroxisome proliferator-activated receptor delta b.	0.626
ENSPREP00000022378	ENSPREP00000014189	ENSPREP00000022378	ENSPREP00000014189	Si:ch211-15p9.2.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.723
ENSPREP00000022378	LOC103475424	ENSPREP00000022378	ENSPREP00000029554	Si:ch211-15p9.2.	Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.667
ENSPREP00000022378	LOC103475425	ENSPREP00000022378	ENSPREP00000029465	Si:ch211-15p9.2.	Uncharacterized protein.	0.612