(49 nodes) RNA Polymerase I Transcription Initiation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ercc2	Excision repair cross-complementation group 2. (655 aa)
	LOC103475151	Uncharacterized protein. (340 aa)
	LOC103471188	Germ cell nuclear acidic peptidase. (437 aa)
	POLR2E	RNA polymerase II subunit E. (210 aa)
	mta3	Metastasis associated 1 family, member 3. (699 aa)
	gtf2h5	General transcription factor IIH, polypeptide 5. (71 aa)
	ccnh	Cyclin H; Belongs to the cyclin family. (319 aa)
	LOC103480197	GATA-type domain-containing protein. (406 aa)
	twistnb	Uncharacterized protein. (369 aa)
	polr1b	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1134 aa)
	cdk7	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily. (387 aa)
	aire	Autoimmune regulator. (496 aa)
	polr1a	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1695 aa)
	tbpl2	Uncharacterized protein. (307 aa)
	LOC103460486	Upstream binding transcription factor, like. (701 aa)
	LOC103472838	Chromodomain helicase DNA binding protein 4a. (1967 aa)
	LOC103463694	GATA zinc finger domain containing 2Ab. (591 aa)
	polr2h	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)
	polr1c	RNA polymerase I and III subunit C. (346 aa)
	taf1a	TATA box binding protein (TBP)-associated factor, RNA polymerase I, A. (417 aa)
	ENSPREP00000012814	Uncharacterized protein. (74 aa)
	polr1e	RNA polymerase I subunit E. (414 aa)
	ubtf	Upstream binding transcription factor. (736 aa)
	tbp	TATA box binding protein. (301 aa)
	chd3	Chromodomain helicase DNA binding protein 3. (1830 aa)
	rrn3	RRN3 homolog, RNA polymerase I transcription factor. (610 aa)
	chd4	Uncharacterized protein. (1981 aa)
	LOC103470674	General transcription factor IIH subunit. (420 aa)
	LOC103460987	Metastasis associated 1 family, member 2. (332 aa)
	mta1	Metastasis associated 1. (584 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (550 aa)
	chd5	Uncharacterized protein. (1804 aa)
	taf1b	TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B. (545 aa)
	mnat1	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (311 aa)
	LOC103481886	Uncharacterized protein. (302 aa)
	ttf1	Uncharacterized protein. (540 aa)
	polr2f	Polymerase (RNA) II (DNA directed) polypeptide F. (98 aa)
	LOC103479433	Uncharacterized protein. (621 aa)
	polr2l	Polymerase (RNA) II (DNA directed) polypeptide L. (67 aa)
	RBBP7	RB binding protein 7, chromatin remodeling factor. (422 aa)
	rbbp4	Retinoblastoma binding protein 4. (424 aa)
	ENSPREP00000031846	Cyclin D binding myb-like transcription factor 1. (350 aa)
	ercc6	Excision repair cross-complementation group 6. (1402 aa)
	ercc3	Excision repair cross-complementation group 3. (783 aa)
	gtf2h3	General transcription factor IIH, polypeptide 3. (277 aa)
	gatad2b	GATA zinc finger domain containing 2B. (589 aa)
	taf1c	Wu:fj64h06. (921 aa)
	znrd1	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (118 aa)
	gtf2h4	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (434 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000012814	LOC103460486	ENSPREP00000012814	ENSPREP00000001918	Uncharacterized protein.	Upstream binding transcription factor, like.	0.651
ENSPREP00000012814	LOC103470674	ENSPREP00000012814	ENSPREP00000017962	Uncharacterized protein.	General transcription factor IIH subunit.	0.963
ENSPREP00000012814	LOC103472838	ENSPREP00000012814	ENSPREP00000001767	Uncharacterized protein.	Chromodomain helicase DNA binding protein 4a.	0.515
ENSPREP00000012814	LOC103475151	ENSPREP00000012814	ENSPREP00000028018	Uncharacterized protein.	Uncharacterized protein.	0.982
ENSPREP00000012814	LOC103481886	ENSPREP00000012814	ENSPREP00000023547	Uncharacterized protein.	Uncharacterized protein.	0.925
ENSPREP00000012814	POLR2E	ENSPREP00000012814	ENSPREP00000009571	Uncharacterized protein.	RNA polymerase II subunit E.	0.999
ENSPREP00000012814	aire	ENSPREP00000012814	ENSPREP00000003639	Uncharacterized protein.	Autoimmune regulator.	0.515
ENSPREP00000012814	ccnh	ENSPREP00000012814	ENSPREP00000006353	Uncharacterized protein.	Cyclin H; Belongs to the cyclin family.	0.927
ENSPREP00000012814	cdk7	ENSPREP00000012814	ENSPREP00000003727	Uncharacterized protein.	Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.	0.787
ENSPREP00000012814	chd3	ENSPREP00000012814	ENSPREP00000016390	Uncharacterized protein.	Chromodomain helicase DNA binding protein 3.	0.515
ENSPREP00000012814	chd4	ENSPREP00000012814	ENSPREP00000016795	Uncharacterized protein.	Uncharacterized protein.	0.515
ENSPREP00000012814	chd5	ENSPREP00000012814	ENSPREP00000021169	Uncharacterized protein.	Uncharacterized protein.	0.515
ENSPREP00000012814	ercc2	ENSPREP00000012814	ENSPREP00000028527	Uncharacterized protein.	Excision repair cross-complementation group 2.	0.964
ENSPREP00000012814	ercc3	ENSPREP00000012814	ENSPREP00000030919	Uncharacterized protein.	Excision repair cross-complementation group 3.	0.963
ENSPREP00000012814	ercc6	ENSPREP00000012814	ENSPREP00000031633	Uncharacterized protein.	Excision repair cross-complementation group 6.	0.957
ENSPREP00000012814	gtf2h1	ENSPREP00000012814	ENSPREP00000019946	Uncharacterized protein.	General transcription factor IIH, polypeptide 1.	0.958
ENSPREP00000012814	gtf2h3	ENSPREP00000012814	ENSPREP00000030691	Uncharacterized protein.	General transcription factor IIH, polypeptide 3.	0.963
ENSPREP00000012814	gtf2h4	ENSPREP00000012814	ENSPREP00000029112	Uncharacterized protein.	General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family.	0.964
ENSPREP00000012814	gtf2h5	ENSPREP00000012814	ENSPREP00000006463	Uncharacterized protein.	General transcription factor IIH, polypeptide 5.	0.929
ENSPREP00000012814	mnat1	ENSPREP00000012814	ENSPREP00000022935	Uncharacterized protein.	CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.	0.966