STRINGSTRING
ENSPREP00000000286 ENSPREP00000000286 ENSPREP00000000287 ENSPREP00000000287 LOC103472958 LOC103472958 LOC103462478 LOC103462478 ENSPREP00000000518 ENSPREP00000000518 ENSPREP00000000618 ENSPREP00000000618 shq1 shq1 LOC103475870 LOC103475870 ankrd28 ankrd28 cenpx cenpx stn1 stn1 cenph cenph LOC103472252 LOC103472252 trub1 trub1 dkc1 dkc1 CENPS CENPS H2AZ1 H2AZ1 atrx atrx rfc2 rfc2 LOC103475985 LOC103475985 rfc5 rfc5 ENSPREP00000007137 ENSPREP00000007137 Nhp2 Nhp2 rpa2 rpa2 ENSPREP00000007704 ENSPREP00000007704 ENSPREP00000007848 ENSPREP00000007848 rbpms2 rbpms2 LOC103474066 LOC103474066 ENSPREP00000008908 ENSPREP00000008908 ENSPREP00000009062 ENSPREP00000009062 terf2ip terf2ip ENSPREP00000009448 ENSPREP00000009448 ENSPREP00000009489 ENSPREP00000009489 ENSPREP00000009934 ENSPREP00000009934 ENSPREP00000009961 ENSPREP00000009961 ENSPREP00000009966 ENSPREP00000009966 prim1 prim1 ccna2 ccna2 rfc1 rfc1 LOC103479103 LOC103479103 ENSPREP00000011186 ENSPREP00000011186 ENSPREP00000011196 ENSPREP00000011196 ENSPREP00000011248 ENSPREP00000011248 blm blm RCBTB1 RCBTB1 LOC103479695 LOC103479695 pif1 pif1 exd2 exd2 rtel1 rtel1 ENSPREP00000012739 ENSPREP00000012739 ENSPREP00000012897 ENSPREP00000012897 ruvbl2 ruvbl2 ENSPREP00000013045 ENSPREP00000013045 ENSPREP00000013055 ENSPREP00000013055 nop10 nop10 dna2 dna2 cenpl cenpl dscc1 dscc1 pold2 pold2 RPA1 RPA1 LOC103474198 LOC103474198 gar1 gar1 rfc3 rfc3 LOC103475329 LOC103475329 cenpi cenpi ccna1 ccna1 pcna pcna recql4 recql4 LOC103473122 LOC103473122 ruvbl1 ruvbl1 terf2 terf2 cenpw cenpw ENSPREP00000018665 ENSPREP00000018665 rfc4 rfc4 rpa3 rpa3 LOC103470692 LOC103470692 cenpn cenpn PPP6C PPP6C pold1 pold1 ENSPREP00000020417 ENSPREP00000020417 cdk2 cdk2 LOC103475008 LOC103475008 pola1 pola1 LOC103476346 LOC103476346 wrap53 wrap53 knl1 knl1 cenpm cenpm meiob meiob ENSPREP00000023704 ENSPREP00000023704 pola2 pola2 pot1 pot1 LOC103458342 LOC103458342 Rsf1 Rsf1 fen1 fen1 terf1 terf1 tert tert LOC103467542 LOC103467542 chtf8 chtf8 LOC103466742 LOC103466742 pold3 pold3 ten1 ten1 lig1 lig1 ankrd44 ankrd44 ENSPREP00000029980 ENSPREP00000029980 ENSPREP00000030043 ENSPREP00000030043 LOC103456580 LOC103456580 ENSPREP00000032241 ENSPREP00000032241 rbbp4 rbbp4 RBBP7 RBBP7 prim2 prim2 pold4 pold4 ENSPREP00000033837 ENSPREP00000033837 LOC103474640 LOC103474640 smarca5 smarca5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPREP00000000286Histone H2A; Belongs to the histone H2A family. (128 aa)
ENSPREP00000000287Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
LOC103472958Histone H2B; Belongs to the histone H2B family. (124 aa)
LOC103462478Histone H2A; Belongs to the histone H2A family. (134 aa)
ENSPREP00000000518CTF18, chromosome transmission fidelity factor 18 homolog (S. cerevisiae). (415 aa)
ENSPREP00000000618Centromere protein K. (221 aa)
shq1SHQ1, H/ACA ribonucleoprotein assembly factor. (519 aa)
LOC103475870Nucleophosmin 1a. (299 aa)
ankrd28Ankyrin repeat domain 28b. (1052 aa)
cenpxCentromere protein X. (74 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (363 aa)
cenphCENP-H domain-containing protein. (238 aa)
LOC103472252ANK_REP_REGION domain-containing protein. (1132 aa)
trub1TruB pseudouridine (psi) synthase family member 1. (277 aa)
dkc1Dyskeratosis congenita 1, dyskerin. (553 aa)
CENPSCentromere protein S. (134 aa)
H2AZ1Histone H2A; Belongs to the histone H2A family. (128 aa)
atrxATRX chromatin remodeler. (2188 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
LOC103475985TERF1 (TRF1)-interacting nuclear factor 2. (560 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
ENSPREP00000007137Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
Nhp2Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (117 aa)
rpa2Replication protein A2. (256 aa)
ENSPREP00000007704Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (98 aa)
ENSPREP00000007848Histone H2B; Belongs to the histone H2B family. (119 aa)
rbpms2RNA binding protein, mRNA processing factor 2b. (220 aa)
LOC103474066Serine/threonine-protein phosphatase. (262 aa)
ENSPREP00000008908Histone H2B; Belongs to the histone H2B family. (134 aa)
ENSPREP00000009062Si:ch211-113a14.22; Belongs to the histone H2B family. (119 aa)
terf2ipBRCT domain-containing protein. (705 aa)
ENSPREP00000009448Histone H2B; Belongs to the histone H2B family. (110 aa)
ENSPREP00000009489Zgc:163040. (93 aa)
ENSPREP00000009934Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (65 aa)
ENSPREP00000009961annotation not available (65 aa)
ENSPREP00000009966Nucleophosmin 1b. (136 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (401 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
rfc1Replication factor C subunit 1. (1090 aa)
LOC103479103Zgc:110269. (322 aa)
ENSPREP00000011186Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSPREP00000011196Histone H2A; Belongs to the histone H2A family. (130 aa)
ENSPREP00000011248Histone H2B; Belongs to the histone H2B family. (120 aa)
blmBLM RecQ like helicase. (1399 aa)
RCBTB1RCC1 and BTB domain containing protein 1. (531 aa)
LOC103479695Histone H2B; Belongs to the histone H2B family. (116 aa)
pif1ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (629 aa)
exd2Exonuclease 3'-5' domain containing 2. (644 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1180 aa)
ENSPREP00000012739Histone H2B; Belongs to the histone H2B family. (120 aa)
ENSPREP00000012897Histone H2B; Belongs to the histone H2B family. (140 aa)
ruvbl2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (459 aa)
ENSPREP00000013045Histone H2B; Belongs to the histone H2B family. (157 aa)
ENSPREP00000013055Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (149 aa)
nop10NOP10 ribonucleoprotein homolog (yeast). (64 aa)
dna2Uncharacterized protein. (1328 aa)
cenplCentromere protein L. (351 aa)
dscc1DNA replication and sister chromatid cohesion 1. (385 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (471 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (674 aa)
LOC103474198Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (537 aa)
gar1H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (234 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC103475329Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (531 aa)
cenpiCentromere protein I. (749 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (402 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
recql4RecQ helicase-like 4. (1237 aa)
LOC103473122Histone domain-containing protein. (169 aa)
ruvbl1RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (456 aa)
terf2HTH myb-type domain-containing protein. (635 aa)
cenpwUncharacterized protein. (86 aa)
ENSPREP00000018665MIS18 kinetochore protein A. (215 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
rpa3Replication protein A3. (122 aa)
LOC103470692Histone H2A; Belongs to the histone H2A family. (128 aa)
cenpnCentromere protein N. (330 aa)
PPP6CSerine/threonine-protein phosphatase. (343 aa)
pold1DNA polymerase. (1102 aa)
ENSPREP00000020417Histone H2A; Belongs to the histone H2A family. (144 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
LOC103475008Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (553 aa)
pola1DNA polymerase. (1478 aa)
LOC103476346Remodeling and spacing factor 1b, tandem duplicate 1. (1987 aa)
wrap53WD repeat containing, antisense to TP53. (545 aa)
knl1Uncharacterized protein. (1688 aa)
cenpmProliferation associated nuclear element. (184 aa)
meiobMethionine sulfoxide reductase B1b. (464 aa)
ENSPREP00000023704SANT domain-containing protein. (297 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (669 aa)
pot1Telo_bind domain-containing protein. (763 aa)
LOC103458342Ankyrin repeat domain 66. (181 aa)
Rsf1Uncharacterized protein. (108 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (396 aa)
terf1Telomeric repeat-binding factor; Binds the telomeric double-stranded 5'-TTAGGG-3' repeat. (367 aa)
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
LOC103467542Histone H2B; Belongs to the histone H2B family. (124 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (134 aa)
LOC103466742Uncharacterized protein. (442 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
ten1TEN1 subunit of CST complex. (134 aa)
lig1DNA ligase. (1002 aa)
ankrd44Ankyrin repeat domain 44. (1054 aa)
ENSPREP00000029980Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSPREP00000030043Histone H2B; Belongs to the histone H2B family. (161 aa)
LOC103456580Uncharacterized protein. (986 aa)
ENSPREP00000032241Uncharacterized protein. (210 aa)
rbbp4Retinoblastoma binding protein 4. (424 aa)
RBBP7RB binding protein 7, chromatin remodeling factor. (422 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa)
pold4Uncharacterized protein. (89 aa)
ENSPREP00000033837Histone H2A; Belongs to the histone H2A family. (136 aa)
LOC103474640Histone H2A; Belongs to the histone H2A family. (138 aa)
smarca5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1037 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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