(6 nodes) Signal attenuation network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000025003	Uncharacterized protein. (394 aa)
	ENSPREP00000030771	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (65 aa)
	LOC103472075	Growth factor receptor-bound protein 10a. (590 aa)
	LOC103476384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (79 aa)
	LOC103478361	Growth factor receptor-bound protein 10b. (572 aa)
	insr	Insulin receptor a. (1178 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000025003	ENSPREP00000030771	ENSPREP00000025003	ENSPREP00000030771	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.766
ENSPREP00000025003	LOC103472075	ENSPREP00000025003	ENSPREP00000026335	Uncharacterized protein.	Growth factor receptor-bound protein 10a.	0.534
ENSPREP00000025003	LOC103476384	ENSPREP00000025003	ENSPREP00000025882	Uncharacterized protein.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.766
ENSPREP00000025003	LOC103478361	ENSPREP00000025003	ENSPREP00000017191	Uncharacterized protein.	Growth factor receptor-bound protein 10b.	0.534
ENSPREP00000030771	ENSPREP00000025003	ENSPREP00000030771	ENSPREP00000025003	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.766
ENSPREP00000030771	LOC103472075	ENSPREP00000030771	ENSPREP00000026335	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10a.	0.447
ENSPREP00000030771	LOC103478361	ENSPREP00000030771	ENSPREP00000017191	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10b.	0.447
ENSPREP00000030771	insr	ENSPREP00000030771	ENSPREP00000020007	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor a.	0.766
LOC103472075	ENSPREP00000025003	ENSPREP00000026335	ENSPREP00000025003	Growth factor receptor-bound protein 10a.	Uncharacterized protein.	0.534
LOC103472075	ENSPREP00000030771	ENSPREP00000026335	ENSPREP00000030771	Growth factor receptor-bound protein 10a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.447
LOC103472075	LOC103476384	ENSPREP00000026335	ENSPREP00000025882	Growth factor receptor-bound protein 10a.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.447
LOC103472075	LOC103478361	ENSPREP00000026335	ENSPREP00000017191	Growth factor receptor-bound protein 10a.	Growth factor receptor-bound protein 10b.	0.901
LOC103472075	insr	ENSPREP00000026335	ENSPREP00000020007	Growth factor receptor-bound protein 10a.	Insulin receptor a.	0.534
LOC103476384	ENSPREP00000025003	ENSPREP00000025882	ENSPREP00000025003	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Uncharacterized protein.	0.766
LOC103476384	LOC103472075	ENSPREP00000025882	ENSPREP00000026335	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10a.	0.447
LOC103476384	LOC103478361	ENSPREP00000025882	ENSPREP00000017191	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Growth factor receptor-bound protein 10b.	0.447
LOC103476384	insr	ENSPREP00000025882	ENSPREP00000020007	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Insulin receptor a.	0.766
LOC103478361	ENSPREP00000025003	ENSPREP00000017191	ENSPREP00000025003	Growth factor receptor-bound protein 10b.	Uncharacterized protein.	0.534
LOC103478361	ENSPREP00000030771	ENSPREP00000017191	ENSPREP00000030771	Growth factor receptor-bound protein 10b.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.447
LOC103478361	LOC103472075	ENSPREP00000017191	ENSPREP00000026335	Growth factor receptor-bound protein 10b.	Growth factor receptor-bound protein 10a.	0.901