STRINGSTRING
SPHK1-2 SPHK1-2 zdhhc21 zdhhc21 pik3r1 pik3r1 hras hras ENSPREP00000027509 ENSPREP00000027509 LOC103466722 LOC103466722 ENSPREP00000027481 ENSPREP00000027481 kras kras LOC103479464 LOC103479464 pdpk1 pdpk1 LOC103470780 LOC103470780 gng2 gng2 shc1 shc1 LOC103466076 LOC103466076 LOC103462484 LOC103462484 strn4 strn4 Pik3ca Pik3ca LOC103475780 LOC103475780 LOC103459297 LOC103459297 akt1 akt1 LOC103481197 LOC103481197 LOC103467856 LOC103467856 LOC103470003 LOC103470003 xpo1 xpo1 LOC103462833 LOC103462833 LOC103465545 LOC103465545 LOC103465881 LOC103465881 LOC103469304 LOC103469304 LOC103462546 LOC103462546 ENSPREP00000002125 ENSPREP00000002125 LOC103468860 LOC103468860 LOC103475907 LOC103475907 LOC103458082 LOC103458082 LOC103459232 LOC103459232 LOC103472243 LOC103472243 Cav1 Cav1 cav2 cav2 pik3r3 pik3r3 LOC103466888 LOC103466888 gng10 gng10 strn3 strn3 LOC103464552 LOC103464552 LOC103464538 LOC103464538 creb1 creb1 esr1 esr1 LOC103472140 LOC103472140 LOC103478998 LOC103478998 LOC103464516 LOC103464516 foxo3 foxo3 LOC103462170 LOC103462170 LOC103474789 LOC103474789 LOC103466654 LOC103466654 prmt1 prmt1 LOC103479066 LOC103479066 prkcz prkcz LOC103468179 LOC103468179 STRN STRN hspb1 hspb1 GNG4 GNG4 gng12 gng12 LOC103476681 LOC103476681 LOC103462605 LOC103462605 LOC103469983 LOC103469983 LOC103469984 LOC103469984 cav3 cav3 LOC103465217 LOC103465217 pik3r2 pik3r2 LOC103465228 LOC103465228 LOC103477318 LOC103477318 LOC103481657 LOC103481657 egf egf gnb1 gnb1 gng7 gng7 SRC SRC LOC103465909 LOC103465909 CSDE1 CSDE1 LOC103463319 LOC103463319 LOC103463555 LOC103463555 gng3 gng3 zdhhc7 zdhhc7 gnb3 gnb3 LOC103473747 LOC103473747 LOC103468320 LOC103468320 uhmk1 uhmk1 LOC103469088 LOC103469088 LOC103463990 LOC103463990 LOC103457917 LOC103457917 HSP90AA1 HSP90AA1 GNG5 GNG5 gnb5 gnb5 ENSPREP00000021885 ENSPREP00000021885 LOC103467178 LOC103467178 LOC103467179 LOC103467179 GNB4 GNB4 ENSPREP00000022514 ENSPREP00000022514 LOC103457290 LOC103457290 SPHK1 SPHK1 LOC103473381 LOC103473381
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPHK1-2Sphingosine kinase 1. (367 aa)
zdhhc21Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (265 aa)
pik3r1Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
hrasHRas proto-oncogene, GTPase a. (189 aa)
ENSPREP00000027509Uncharacterized protein. (132 aa)
LOC103466722Uncharacterized protein. (284 aa)
ENSPREP00000027481Uncharacterized protein. (54 aa)
krasV-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
LOC103479464Uncharacterized protein. (314 aa)
pdpk13-phosphoinositide dependent protein kinase 1b. (538 aa)
LOC103470780Uncharacterized protein. (705 aa)
gng2Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
shc1SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
LOC103466076Uncharacterized protein. (354 aa)
LOC103462484ZP domain-containing protein. (415 aa)
strn4Striatin, calmodulin binding protein 4. (738 aa)
Pik3caUncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
LOC103475780WD_REPEATS_REGION domain-containing protein. (223 aa)
LOC103459297Uncharacterized protein. (285 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
LOC103481197Protein arginine methyltransferase 8; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (412 aa)
LOC103467856Tyrosine-protein kinase. (542 aa)
LOC103470003Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
xpo1Exportin 1 (CRM1 homolog, yeast) a. (1066 aa)
LOC103462833Guanine nucleotide binding protein (G protein), gamma 13a. (67 aa)
LOC103465545Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
LOC103465881Guanine nucleotide binding protein (G protein) alpha v1. (334 aa)
LOC103469304Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
LOC103462546Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, b. (374 aa)
ENSPREP00000002125ZP domain-containing protein. (372 aa)
LOC103468860Uncharacterized protein. (376 aa)
LOC103475907Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
LOC103458082Estrogen receptor 2b. (664 aa)
LOC103459232Protein arginine methyltransferase 8b; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (405 aa)
LOC103472243Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (73 aa)
Cav1Uncharacterized protein. (84 aa)
cav2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (177 aa)
pik3r3Uncharacterized protein. (474 aa)
LOC103466888Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (172 aa)
gng10Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
strn3Striatin, calmodulin binding protein 3. (702 aa)
LOC103464552Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (184 aa)
LOC103464538Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2b. (355 aa)
creb1Uncharacterized protein. (331 aa)
esr1Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
LOC103472140Striatin, calmodulin binding protein. (779 aa)
LOC103478998Uncharacterized protein. (512 aa)
LOC103464516Guanine nucleotide binding protein (G protein), beta polypeptide 1b. (340 aa)
foxo3Forkhead box O3b. (644 aa)
LOC103462170Guanine nucleotide binding protein (G protein), beta 5b. (345 aa)
LOC103474789Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
LOC103466654Tyrosine-protein kinase receptor. (1415 aa)
prmt1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (383 aa)
LOC103479066Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
prkczProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
LOC103468179Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
STRNStriatin. (744 aa)
hspb1Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
GNG4Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
gng12Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (96 aa)
LOC103476681Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
LOC103462605Tyrosine-protein kinase receptor. (1403 aa)
LOC103469983EGF-like domain-containing protein. (154 aa)
LOC103469984EGF-like domain-containing protein. (176 aa)
cav3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
LOC103465217Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (159 aa)
pik3r2Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (701 aa)
LOC103465228Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2a. (355 aa)
LOC103477318Exportin 1 (CRM1 homolog, yeast) b. (1071 aa)
LOC103481657Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (70 aa)
egfEpidermal growth factor. (942 aa)
gnb1Guanine nucleotide binding protein (G protein), beta polypeptide 1a. (340 aa)
gng7Guanine nucleotide binding protein (G protein), gamma 7. (78 aa)
SRCTyrosine-protein kinase. (569 aa)
LOC103465909Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
CSDE1Cold shock domain containing E1, RNA-binding. (912 aa)
LOC103463319Uncharacterized protein. (406 aa)
LOC103463555Sphingosine-1-phosphate receptor 3a; Belongs to the G-protein coupled receptor 1 family. (396 aa)
gng3Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (75 aa)
zdhhc7Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (320 aa)
gnb3Guanine nucleotide binding protein (G protein), beta polypeptide 3a. (296 aa)
LOC103473747Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (199 aa)
LOC103468320Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (67 aa)
uhmk1U2AF homology motif (UHM) kinase 1. (443 aa)
LOC103469088Zgc:55558. (191 aa)
LOC103463990Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (72 aa)
LOC103457917Heat shock protein 90, alpha (cytosolic), class A member 1, tandem duplicate 1. (767 aa)
HSP90AA1Heat shock protein 90 alpha family class A member 1. (496 aa)
GNG5Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
gnb5Guanine nucleotide binding protein (G protein), beta 5a. (380 aa)
ENSPREP00000021885Uncharacterized protein. (80 aa)
LOC103467178Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3. (303 aa)
LOC103467179Guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2. (350 aa)
GNB4G protein subunit beta 4. (340 aa)
ENSPREP00000022514ZP domain-containing protein. (320 aa)
LOC103457290Estrogen receptor 2a. (507 aa)
SPHK1Sphingosine kinase 1. (564 aa)
LOC103473381cAMP responsive element binding protein 1. (317 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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