(100 nodes) RHOC GTPase cycle network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103464037	MCF.2 cell line derived transforming sequence-like 2. (1009 aa)
	LOC103465321	Junction plakoglobin a. (721 aa)
	LOC103464955	Uncharacterized protein. (628 aa)
	LOC103480907	TGc domain-containing protein. (508 aa)
	arhgap5	Rho GTPase activating protein 5. (1499 aa)
	Cav1	Uncharacterized protein. (84 aa)
	LOC103472579	STE20-like kinase b. (1004 aa)
	LOC103466362	Si:dkey-30c15.10. (733 aa)
	maco1	Macoilin 1b. (680 aa)
	LOC103458650	Oligodendrocyte transcription factor 4. (256 aa)
	LOC103479192	Transferrin receptor 1a. (519 aa)
	LOC108167061	Uncharacterized protein. (100 aa)
	ENSPREP00000004746	V-SNARE coiled-coil homology domain-containing protein. (94 aa)
	LOC103482185	Caveolae associated protein 1b. (397 aa)
	LOC103463400	Uncharacterized protein. (196 aa)
	LOC103479584	Rho GTPase activating protein 21b. (1781 aa)
	olig2	Oligodendrocyte lineage transcription factor 2. (273 aa)
	ENSPREP00000005434	BHLH domain-containing protein. (212 aa)
	pkn3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	daam2	Dishevelled associated activator of morphogenesis 2. (1083 aa)
	LOC103475402	Serine/threonine kinase 10. (717 aa)
	Akap13	ANK_REP_REGION domain-containing protein. (1453 aa)
	rock2	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1401 aa)
	rnft2	Ring finger protein, transmembrane 2. (448 aa)
	abcd3	ATP-binding cassette, sub-family D (ALD), member 3a. (659 aa)
	rtkn	Rhotekin. (790 aa)
	ABR	ABR activator of RhoGEF and GTPase. (1099 aa)
	LOC103474060	Protein kinase N3. (1203 aa)
	tjp2	Tight junction protein 2a (zona occludens 2); Belongs to the MAGUK family. (1077 aa)
	rock1	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1263 aa)
	VANGL1	Vang-like protein. (527 aa)
	LOC103460746	Si:ch1073-416j23.1. (674 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (434 aa)
	LOC103473601	BCR activator of RhoGEF and GTPase. (1374 aa)
	pkn2	Protein kinase N2. (975 aa)
	LOC103472976	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (350 aa)
	LOC103479717	Mcf.2 cell line derived transforming sequence-like b. (1176 aa)
	LOC103476674	Rhotekin 2a. (651 aa)
	c1qbp	Complement component 1, q subcomponent binding protein. (289 aa)
	arhgef11	Rho guanine nucleotide exchange factor (GEF) 11. (1475 aa)
	LOC103467292	DLC1 Rho GTPase activating protein. (1981 aa)
	olig3	Oligodendrocyte transcription factor 3. (220 aa)
	rnft1	Ring finger protein, transmembrane 1. (435 aa)
	cav3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (163 aa)
	LOC103469402	Caveolae associated protein 1a. (393 aa)
	mcf2	MCF.2 cell line derived transforming sequence a. (1145 aa)
	ENSPREP00000015179	TGc domain-containing protein. (579 aa)
	LOC103470008	Rho guanine nucleotide exchange factor 28. (1467 aa)
	ENSPREP00000016162	Uncharacterized protein. (1015 aa)
	LOC103464667	VAMP (vesicle-associated membrane protein)-associated protein B and C. (241 aa)
	mcf2l	Mcf.2 cell line derived transforming sequence-like a. (1028 aa)
	prex1	Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1. (1503 aa)
	LOC103474970	StAR-related lipid transfer (START) domain containing 13b. (1454 aa)
	LOC103465265	Uncharacterized protein. (661 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	anln	Anillin, actin binding protein. (1138 aa)
	slk	STE20-like kinase a. (1157 aa)
	LOC103468356	Protein kinase N1b. (919 aa)
	arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like a. (997 aa)
	ENSPREP00000021285	DH domain-containing protein. (251 aa)
	depdc1b	Rho-GAP domain-containing protein. (532 aa)
	arhgef1	Rho guanine nucleotide exchange factor (GEF) 1b. (1039 aa)
	ENSPREP00000021609	Uncharacterized protein. (93 aa)
	stx5	Syntaxin 5A; Belongs to the syntaxin family. (330 aa)
	LOC103476311	Melanoma cell adhesion molecule a. (644 aa)
	LOC103469600	Citron rho-interacting serine/threonine kinase b. (1537 aa)
	arhgdia	Rho GDP dissociation inhibitor (GDI) alpha. (205 aa)
	iqgap3	IQ motif containing GTPase activating protein 3. (1756 aa)
	Bcr	Si:dkey-91m11.5. (609 aa)
	ENSPREP00000024183	Rho-GAP domain-containing protein. (214 aa)
	ipo11	Importin 11. (994 aa)
	myo9b	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2278 aa)
	LOC103472051	Macoilin 1a. (673 aa)
	LOC103466715	Transglutaminase 2, like. (696 aa)
	iqgap1	IQ motif containing GTPase activating protein 1. (1638 aa)
	arhgap1	Uncharacterized protein. (430 aa)
	lman1	Lectin, mannose-binding, 1. (509 aa)
	pkn1	Protein kinase N1a. (790 aa)
	LOC103467280	TGc domain-containing protein. (676 aa)
	LOC103464226	Rho GTPase activating protein 39. (1021 aa)
	daam1	Dishevelled associated activator of morphogenesis 1b. (1081 aa)
	fmnl3	Formin-like 3. (1001 aa)
	LOC103475233	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	ophn1	Oligophrenin 1. (823 aa)
	Arhgef28	Phorbol-ester/DAG-type domain-containing protein. (99 aa)
	ENSPREP00000030922	PH domain-containing protein. (592 aa)
	ENSPREP00000031039	Rho guanine nucleotide exchange factor (GEF) 17. (435 aa)
	LOC103472754	Rho guanine nucleotide exchange factor (GEF) 40. (1738 aa)
	LOC103467350	Uncharacterized protein. (690 aa)
	diaph3	Diaphanous-related formin 3. (1226 aa)
	LOC103464971	Citron Rho-interacting kinase; Plays a role in cytokinesis. Displays serine/threonine protein kinase activity; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. (1972 aa)
	LOC103475743	Rho GTPase activating protein 35b. (1529 aa)
	ENSPREP00000032370	TGc domain-containing protein. (561 aa)
	Arhgef12	DH domain-containing protein. (250 aa)
	ENSPREP00000032838	PDZ domain-containing protein. (113 aa)
	LOC103464295	TGc domain-containing protein. (614 aa)
	LOC103465571	Zgc:92107. (1138 aa)
	racgap1	Rac GTPase activating protein 1. (630 aa)
	arhgap35	Uncharacterized protein. (1553 aa)
	arhgap21	Rho GTPase activating protein 21a. (1717 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABR	arhgap1	ENSPREP00000008749	ENSPREP00000026198	ABR activator of RhoGEF and GTPase.	Uncharacterized protein.	0.516
ABR	daam1	ENSPREP00000008749	ENSPREP00000029627	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 1b.	0.410
ABR	daam2	ENSPREP00000008749	ENSPREP00000006053	ABR activator of RhoGEF and GTPase.	Dishevelled associated activator of morphogenesis 2.	0.410
ABR	myo9b	ENSPREP00000008749	ENSPREP00000025222	ABR activator of RhoGEF and GTPase.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
Arhgef12	ENSPREP00000031039	ENSPREP00000032828	ENSPREP00000031039	DH domain-containing protein.	Rho guanine nucleotide exchange factor (GEF) 17.	0.449
Arhgef12	arhgef10l	ENSPREP00000032828	ENSPREP00000021019	DH domain-containing protein.	Rho guanine nucleotide exchange factor (GEF) 10-like a.	0.402
Arhgef12	rock1	ENSPREP00000032828	ENSPREP00000009624	DH domain-containing protein.	Rho-associated, coiled-coil containing protein kinase 1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.	0.443
Arhgef12	rock2	ENSPREP00000032828	ENSPREP00000007499	DH domain-containing protein.	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity.	0.443
Bcr	ENSPREP00000024183	ENSPREP00000024152	ENSPREP00000024183	Si:dkey-91m11.5.	Rho-GAP domain-containing protein.	0.897
Bcr	arhgap1	ENSPREP00000024152	ENSPREP00000026198	Si:dkey-91m11.5.	Uncharacterized protein.	0.516
Bcr	daam1	ENSPREP00000024152	ENSPREP00000029627	Si:dkey-91m11.5.	Dishevelled associated activator of morphogenesis 1b.	0.410
Bcr	daam2	ENSPREP00000024152	ENSPREP00000006053	Si:dkey-91m11.5.	Dishevelled associated activator of morphogenesis 2.	0.410
Bcr	myo9b	ENSPREP00000024152	ENSPREP00000025222	Si:dkey-91m11.5.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.593
Cav1	ENSPREP00000004746	ENSPREP00000003891	ENSPREP00000004746	Uncharacterized protein.	V-SNARE coiled-coil homology domain-containing protein.	0.424
Cav1	LOC103465321	ENSPREP00000003891	ENSPREP00000000600	Uncharacterized protein.	Junction plakoglobin a.	0.458
Cav1	LOC103469402	ENSPREP00000003891	ENSPREP00000014515	Uncharacterized protein.	Caveolae associated protein 1a.	0.697
Cav1	LOC103472976	ENSPREP00000003891	ENSPREP00000011522	Uncharacterized protein.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.466
Cav1	LOC103475233	ENSPREP00000003891	ENSPREP00000030737	Uncharacterized protein.	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily.	0.466
Cav1	LOC103479192	ENSPREP00000003891	ENSPREP00000004593	Uncharacterized protein.	Transferrin receptor 1a.	0.414
Cav1	LOC103482185	ENSPREP00000003891	ENSPREP00000005200	Uncharacterized protein.	Caveolae associated protein 1b.	0.697