(41 nodes) Biosynthesis of specialized proresolving mediators (SPMs) network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103462633	Uncharacterized protein. (154 aa)
	LOC103476434	Uncharacterized protein; Belongs to the cytochrome P450 family. (518 aa)
	LOC103476433	Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
	ENSPREP00000003914	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family. (507 aa)
	ENSPREP00000003955	Cytochrome P450, family 2, subfamily N, polypeptide 13. (477 aa)
	LOC103480141	Arachidonate 12-lipoxygenase. (670 aa)
	ENSPREP00000004689	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family. (502 aa)
	mest	Mesoderm specific transcript. (338 aa)
	ENSPREP00000005565	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family. (497 aa)
	ENSPREP00000005749	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family. (493 aa)
	LOC103463736	Uncharacterized protein; Belongs to the cytochrome P450 family. (498 aa)
	LOC103475970	Prostaglandin reductase 1. (307 aa)
	hpgd	15-hydroxyprostaglandin dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (292 aa)
	LOC103475975	Prostaglandin reductase 1. (329 aa)
	LOC103461257	Uncharacterized protein; Belongs to the cytochrome P450 family. (470 aa)
	LOC103463738	Uncharacterized protein; Belongs to the cytochrome P450 family. (502 aa)
	LOC103463739	Uncharacterized protein; Belongs to the cytochrome P450 family. (505 aa)
	ENSPREP00000008009	Uncharacterized protein; Belongs to the cytochrome P450 family. (144 aa)
	ENSPREP00000008098	Uncharacterized protein; Belongs to the cytochrome P450 family. (452 aa)
	ENSPREP00000008109	Uncharacterized protein. (328 aa)
	ENSPREP00000008146	Uncharacterized protein. (225 aa)
	LOC103460018	Uncharacterized protein. (175 aa)
	GPX4	Glutathione peroxidase 4. (144 aa)
	LOC103461467	Cytochrome P450, family 3, subfamily A, polypeptide 65. (197 aa)
	LOC103462617	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family. (589 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	LOC103470577	Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family. (535 aa)
	alox5ap	Arachidonate 5-lipoxygenase-activating protein. (156 aa)
	LOC103463586	Uncharacterized protein; Belongs to the cytochrome P450 family. (500 aa)
	LOC103471803	Leukotriene C4 synthase. (176 aa)
	LOC103479268	Glutathione peroxidase 4b. (179 aa)
	ptgr2	Prostaglandin reductase 2. (347 aa)
	C1orf146	Chromosome 1 open reading frame 146. (172 aa)
	LOC103463979	Si:ch73-389b16.2. (1535 aa)
	ephx4	Epoxide hydrolase 4. (369 aa)
	ephx2	Epoxide hydrolase 2, cytoplasmic. (561 aa)
	LOC103466716	Uncharacterized protein; Belongs to the cytochrome P450 family. (489 aa)
	LOC103466717	Uncharacterized protein; Belongs to the cytochrome P450 family. (480 aa)
	LOC103475118	Uncharacterized protein; Belongs to the cytochrome P450 family. (555 aa)
	lta4h	Leukotriene A(4) hydrolase; Belongs to the peptidase M1 family. (614 aa)
	alox5	Arachidonate 5-lipoxygenase a. (673 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000003914	LOC103461467	ENSPREP00000003914	ENSPREP00000010024	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.526
ENSPREP00000003955	ENSPREP00000008009	ENSPREP00000003955	ENSPREP00000008009	Cytochrome P450, family 2, subfamily N, polypeptide 13.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.617
ENSPREP00000003955	LOC103461467	ENSPREP00000003955	ENSPREP00000010024	Cytochrome P450, family 2, subfamily N, polypeptide 13.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.526
ENSPREP00000004689	LOC103461467	ENSPREP00000004689	ENSPREP00000010024	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.526
ENSPREP00000005565	LOC103461467	ENSPREP00000005565	ENSPREP00000010024	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.526
ENSPREP00000005749	LOC103461467	ENSPREP00000005749	ENSPREP00000010024	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.523
ENSPREP00000005749	LOC103463736	ENSPREP00000005749	ENSPREP00000005772	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.905
ENSPREP00000005749	LOC103480141	ENSPREP00000005749	ENSPREP00000004315	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Arachidonate 12-lipoxygenase.	0.902
ENSPREP00000005749	alox5	ENSPREP00000005749	ENSPREP00000028167	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Arachidonate 5-lipoxygenase a.	0.902
ENSPREP00000005749	ephx2	ENSPREP00000005749	ENSPREP00000021989	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Epoxide hydrolase 2, cytoplasmic.	0.920
ENSPREP00000005749	ptgs2	ENSPREP00000005749	ENSPREP00000013319	Cytochrome P450, family 2, subfamily AD, polypeptide 2; Belongs to the cytochrome P450 family.	Prostaglandin-endoperoxide synthase 2b.	0.901
ENSPREP00000008009	ENSPREP00000003955	ENSPREP00000008009	ENSPREP00000003955	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450, family 2, subfamily N, polypeptide 13.	0.617
ENSPREP00000008009	LOC103461467	ENSPREP00000008009	ENSPREP00000010024	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450, family 3, subfamily A, polypeptide 65.	0.899
ENSPREP00000008009	LOC103462617	ENSPREP00000008009	ENSPREP00000012206	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450, family 1, subfamily A; Belongs to the cytochrome P450 family.	0.430
ENSPREP00000008009	LOC103462633	ENSPREP00000008009	ENSPREP00000000022	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.900
ENSPREP00000008009	LOC103470577	ENSPREP00000008009	ENSPREP00000013628	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cytochrome P450, family 1, subfamily D, polypeptide 1; Belongs to the cytochrome P450 family.	0.435
ENSPREP00000008009	LOC103475118	ENSPREP00000008009	ENSPREP00000027058	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.629
LOC103461467	ENSPREP00000003914	ENSPREP00000010024	ENSPREP00000003914	Cytochrome P450, family 3, subfamily A, polypeptide 65.	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family.	0.526
LOC103461467	ENSPREP00000003955	ENSPREP00000010024	ENSPREP00000003955	Cytochrome P450, family 3, subfamily A, polypeptide 65.	Cytochrome P450, family 2, subfamily N, polypeptide 13.	0.526
LOC103461467	ENSPREP00000004689	ENSPREP00000010024	ENSPREP00000004689	Cytochrome P450, family 3, subfamily A, polypeptide 65.	Cytochrome P450, family 2, subfamily N, polypeptide 13; Belongs to the cytochrome P450 family.	0.526