(10 nodes) Negative regulation of NOTCH4 signaling network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSPREP00000022311	Transforming, acidic coiled-coil containing protein 3. (781 aa)
	LOC103473166	Uncharacterized protein. (1465 aa)
	crb2	Crumbs cell polarity complex component 2b. (1343 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	Eys	Uncharacterized protein. (303 aa)
	LOC103463303	Crumbs cell polarity complex component 1. (1334 aa)
	ENSPREP00000033301	Uncharacterized protein. (756 aa)
	ENSPREP00000008634	Uncharacterized protein. (690 aa)
	ENSPREP00000033286	Uncharacterized protein. (373 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000008634	ENSPREP00000033301	ENSPREP00000008634	ENSPREP00000033301	Uncharacterized protein.	Uncharacterized protein.	0.647
ENSPREP00000022311	ENSPREP00000033286	ENSPREP00000022311	ENSPREP00000033286	Transforming, acidic coiled-coil containing protein 3.	Uncharacterized protein.	0.452
ENSPREP00000022311	ENSPREP00000033301	ENSPREP00000022311	ENSPREP00000033301	Transforming, acidic coiled-coil containing protein 3.	Uncharacterized protein.	0.452
ENSPREP00000022311	Eys	ENSPREP00000022311	ENSPREP00000033305	Transforming, acidic coiled-coil containing protein 3.	Uncharacterized protein.	0.452
ENSPREP00000033286	ENSPREP00000022311	ENSPREP00000033286	ENSPREP00000022311	Uncharacterized protein.	Transforming, acidic coiled-coil containing protein 3.	0.452
ENSPREP00000033286	Eys	ENSPREP00000033286	ENSPREP00000033305	Uncharacterized protein.	Uncharacterized protein.	0.887
ENSPREP00000033301	ENSPREP00000008634	ENSPREP00000033301	ENSPREP00000008634	Uncharacterized protein.	Uncharacterized protein.	0.647
ENSPREP00000033301	ENSPREP00000022311	ENSPREP00000033301	ENSPREP00000022311	Uncharacterized protein.	Transforming, acidic coiled-coil containing protein 3.	0.452
ENSPREP00000033301	Eys	ENSPREP00000033301	ENSPREP00000033305	Uncharacterized protein.	Uncharacterized protein.	0.843
Eys	ENSPREP00000022311	ENSPREP00000033305	ENSPREP00000022311	Uncharacterized protein.	Transforming, acidic coiled-coil containing protein 3.	0.452
Eys	ENSPREP00000033286	ENSPREP00000033305	ENSPREP00000033286	Uncharacterized protein.	Uncharacterized protein.	0.887
Eys	ENSPREP00000033301	ENSPREP00000033305	ENSPREP00000033301	Uncharacterized protein.	Uncharacterized protein.	0.843