(10 nodes) Biotin-requiring enzyme network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mccc1	Methylcrotonoyl-CoA carboxylase 1 (alpha). (714 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	pc	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1180 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (436 aa)
	pdhx	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (493 aa)
	dlat	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (643 aa)
	LOC103459060	Dihydrolipoamide S-succinyltransferase. (433 aa)
	pcca	Propionyl-CoA carboxylase subunit alpha. (657 aa)
	dbt	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (492 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2251 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DLST	dbt	ENSPREP00000028927	ENSPREP00000008184	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.701
DLST	dlat	ENSPREP00000028927	ENSPREP00000026249	Dihydrolipoamide S-succinyltransferase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.901
DLST	mccc1	ENSPREP00000028927	ENSPREP00000033480	Dihydrolipoamide S-succinyltransferase.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.471
DLST	pc	ENSPREP00000028927	ENSPREP00000029584	Dihydrolipoamide S-succinyltransferase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.409
DLST	pcca	ENSPREP00000028927	ENSPREP00000011142	Dihydrolipoamide S-succinyltransferase.	Propionyl-CoA carboxylase subunit alpha.	0.471
DLST	pdhx	ENSPREP00000028927	ENSPREP00000028190	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.903
LOC103459060	dbt	ENSPREP00000013689	ENSPREP00000008184	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.705
LOC103459060	dlat	ENSPREP00000013689	ENSPREP00000026249	Dihydrolipoamide S-succinyltransferase.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.900
LOC103459060	mccc1	ENSPREP00000013689	ENSPREP00000033480	Dihydrolipoamide S-succinyltransferase.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.471
LOC103459060	pc	ENSPREP00000013689	ENSPREP00000029584	Dihydrolipoamide S-succinyltransferase.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.409
LOC103459060	pcca	ENSPREP00000013689	ENSPREP00000011142	Dihydrolipoamide S-succinyltransferase.	Propionyl-CoA carboxylase subunit alpha.	0.471
LOC103459060	pdhx	ENSPREP00000013689	ENSPREP00000028190	Dihydrolipoamide S-succinyltransferase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.902
acaca	acacb	ENSPREP00000001848	ENSPREP00000033271	Acetyl-CoA carboxylase alpha.	Acetyl-CoA carboxylase beta.	0.901
acaca	dlat	ENSPREP00000001848	ENSPREP00000026249	Acetyl-CoA carboxylase alpha.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.929
acaca	mccc1	ENSPREP00000001848	ENSPREP00000033480	Acetyl-CoA carboxylase alpha.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.719
acaca	pc	ENSPREP00000001848	ENSPREP00000029584	Acetyl-CoA carboxylase alpha.	Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.	0.701
acaca	pcca	ENSPREP00000001848	ENSPREP00000011142	Acetyl-CoA carboxylase alpha.	Propionyl-CoA carboxylase subunit alpha.	0.719
acacb	acaca	ENSPREP00000033271	ENSPREP00000001848	Acetyl-CoA carboxylase beta.	Acetyl-CoA carboxylase alpha.	0.901
acacb	dlat	ENSPREP00000033271	ENSPREP00000026249	Acetyl-CoA carboxylase beta.	Acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.929
acacb	mccc1	ENSPREP00000033271	ENSPREP00000033480	Acetyl-CoA carboxylase beta.	Methylcrotonoyl-CoA carboxylase 1 (alpha).	0.719