9 items (Poecilia reticulata) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Input:
	uba5	Ubiquitin-like modifier activating enzyme 5. (400 aa)
	UBA3	Ubiquitin like modifier activating enzyme 3. (462 aa)
	mocs3	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...] (459 aa)
	nae1	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily. (533 aa)
	sae1	SUMO1 activating enzyme subunit 1. (344 aa)
	LOC103467931	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family. (768 aa)
	LOC103465053	Ubiquitin-like modifier activating enzyme 3. (442 aa)
	uba2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (599 aa)
	atg7	ATG7 autophagy related 7 homolog (S. cerevisiae). (720 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103465053	LOC103467931	ENSPREP00000026705	ENSPREP00000028974	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.664
LOC103465053	UBA3	ENSPREP00000026705	ENSPREP00000006714	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin like modifier activating enzyme 3.	0.900
LOC103465053	atg7	ENSPREP00000026705	ENSPREP00000009567	Ubiquitin-like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.757
LOC103465053	mocs3	ENSPREP00000026705	ENSPREP00000000990	Ubiquitin-like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.486
LOC103465053	nae1	ENSPREP00000026705	ENSPREP00000033169	Ubiquitin-like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.989
LOC103465053	sae1	ENSPREP00000026705	ENSPREP00000029023	Ubiquitin-like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.444
LOC103465053	uba5	ENSPREP00000026705	ENSPREP00000013586	Ubiquitin-like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.774
LOC103467931	LOC103465053	ENSPREP00000028974	ENSPREP00000026705	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 3.	0.664
LOC103467931	UBA3	ENSPREP00000028974	ENSPREP00000006714	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin like modifier activating enzyme 3.	0.664
LOC103467931	atg7	ENSPREP00000028974	ENSPREP00000009567	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.750
LOC103467931	mocs3	ENSPREP00000028974	ENSPREP00000000990	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.408
LOC103467931	uba5	ENSPREP00000028974	ENSPREP00000013586	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	Ubiquitin-like modifier activating enzyme 5.	0.743
UBA3	LOC103465053	ENSPREP00000006714	ENSPREP00000026705	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 3.	0.900
UBA3	LOC103467931	ENSPREP00000006714	ENSPREP00000028974	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 1; Belongs to the ubiquitin-activating E1 family.	0.664
UBA3	atg7	ENSPREP00000006714	ENSPREP00000009567	Ubiquitin like modifier activating enzyme 3.	ATG7 autophagy related 7 homolog (S. cerevisiae).	0.757
UBA3	mocs3	ENSPREP00000006714	ENSPREP00000000990	Ubiquitin like modifier activating enzyme 3.	Adenylyltransferase and sulfurtransferase MOCS3; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl- adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (- COSH) of their C-terminus. The reaction probably involves hydrogen sulfide [...]	0.486
UBA3	nae1	ENSPREP00000006714	ENSPREP00000033169	Ubiquitin like modifier activating enzyme 3.	NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.	0.989
UBA3	sae1	ENSPREP00000006714	ENSPREP00000029023	Ubiquitin like modifier activating enzyme 3.	SUMO1 activating enzyme subunit 1.	0.444
UBA3	uba5	ENSPREP00000006714	ENSPREP00000013586	Ubiquitin like modifier activating enzyme 3.	Ubiquitin-like modifier activating enzyme 5.	0.774
atg7	LOC103465053	ENSPREP00000009567	ENSPREP00000026705	ATG7 autophagy related 7 homolog (S. cerevisiae).	Ubiquitin-like modifier activating enzyme 3.	0.757