(9 nodes) (2017) Annonaceae: Breaking the Wall of Inflammation. network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103480049	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (122 aa)
	prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
	relb	V-rel avian reticuloendotheliosis viral oncogene homolog B. (579 aa)
	vcam1	Vascular cell adhesion molecule 1b. (929 aa)
	il10	Interleukin 10. (229 aa)
	LOC103468785	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC103479663	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	calm2	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103468785	LOC103479663	ENSPREP00000006192	ENSPREP00000014181	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.900
LOC103468785	prkaca	ENSPREP00000006192	ENSPREP00000000445	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103468785	prkacb	ENSPREP00000006192	ENSPREP00000021366	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103468785	relb	ENSPREP00000006192	ENSPREP00000000749	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.451
LOC103479663	LOC103468785	ENSPREP00000014181	ENSPREP00000006192	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
LOC103479663	prkaca	ENSPREP00000014181	ENSPREP00000000445	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103479663	prkacb	ENSPREP00000014181	ENSPREP00000021366	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
LOC103479663	relb	ENSPREP00000014181	ENSPREP00000000749	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.451
LOC103480049	relb	ENSPREP00000030388	ENSPREP00000000749	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.605
LOC103480049	vcam1	ENSPREP00000030388	ENSPREP00000001764	Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex.	Vascular cell adhesion molecule 1b.	0.597
il10	vcam1	ENSPREP00000005577	ENSPREP00000001764	Interleukin 10.	Vascular cell adhesion molecule 1b.	0.525
prkaca	LOC103468785	ENSPREP00000000445	ENSPREP00000006192	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
prkaca	LOC103479663	ENSPREP00000000445	ENSPREP00000014181	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.900
prkaca	prkacb	ENSPREP00000000445	ENSPREP00000021366	Uncharacterized protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
prkaca	relb	ENSPREP00000000445	ENSPREP00000000749	Uncharacterized protein; Belongs to the protein kinase superfamily.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.451
prkacb	LOC103468785	ENSPREP00000021366	ENSPREP00000006192	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.900
prkacb	LOC103479663	ENSPREP00000021366	ENSPREP00000014181	Uncharacterized protein; Belongs to the protein kinase superfamily.	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily.	0.900
prkacb	prkaca	ENSPREP00000021366	ENSPREP00000000445	Uncharacterized protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the protein kinase superfamily.	0.900
prkacb	relb	ENSPREP00000021366	ENSPREP00000000749	Uncharacterized protein; Belongs to the protein kinase superfamily.	V-rel avian reticuloendotheliosis viral oncogene homolog B.	0.451
relb	LOC103468785	ENSPREP00000000749	ENSPREP00000006192	V-rel avian reticuloendotheliosis viral oncogene homolog B.	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily.	0.451