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tert tert LOC103477443 LOC103477443 tyrp1 tyrp1 TGFBR2 TGFBR2 hif1a hif1a prkacb prkacb braf braf tgfbr2 tgfbr2 SRC SRC ENSPREP00000016282 ENSPREP00000016282 LOC103457029 LOC103457029 LOC103469120 LOC103469120 dip2a dip2a stat3 stat3 LOC103479663 LOC103479663 jak2 jak2 LOC103469343 LOC103469343 LOC103474858 LOC103474858 suv39h1 suv39h1 RAC1 RAC1 HIST2H3PS2 HIST2H3PS2 LOC103461301 LOC103461301 LOC103468785 LOC103468785 bcl2 bcl2 dct dct PTEN PTEN ENSPREP00000002301 ENSPREP00000002301 prkaca prkaca PLK1 PLK1 stat1 stat1 ENSPREP00000032744 ENSPREP00000032744 cdc6 cdc6 LOC103465526 LOC103465526 akt1 akt1 LOC103467856 LOC103467856 LOC103475214 LOC103475214 LOC103481975 LOC103481975 thbs1 thbs1 H3-3B H3-3B ENSPREP00000027875 ENSPREP00000027875
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tertTelomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1098 aa)
LOC103477443Runt-related transcription factor. (484 aa)
tyrp1Tyrosinase related protein 1. (525 aa)
TGFBR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (544 aa)
hif1aHypoxia inducible factor 1 subunit alpha a. (740 aa)
prkacbUncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
brafB-Raf proto-oncogene, serine/threonine kinase. (781 aa)
tgfbr2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (591 aa)
SRCTyrosine-protein kinase. (569 aa)
ENSPREP00000016282TRAF2 and NCK interacting kinase b. (498 aa)
LOC103457029TRAF2 and NCK interacting kinase b. (179 aa)
LOC103469120Tyrosinase-related protein 1b. (549 aa)
dip2aDisco-interacting protein 2 homolog A. (1633 aa)
stat3Signal transducer and activator of transcription. (825 aa)
LOC103479663Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
jak2Tyrosine-protein kinase. (1190 aa)
LOC103469343HEXIM P-TEFb complex subunit 1. (367 aa)
LOC103474858Histone H3; Belongs to the histone H3 family. (138 aa)
suv39h1Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (421 aa)
RAC1Rac family small GTPase 1. (192 aa)
HIST2H3PS2Histone H3; Belongs to the histone H3 family. (96 aa)
LOC103461301Histone H3; Belongs to the histone H3 family. (90 aa)
LOC103468785Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
bcl2BCL2 apoptosis regulator b. (230 aa)
dctDopachrome tautomerase. (528 aa)
PTENPhosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (412 aa)
ENSPREP00000002301Histone H3; Belongs to the histone H3 family. (92 aa)
prkacaUncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
PLK1Serine/threonine-protein kinase PLK. (581 aa)
stat1Signal transducer and activator of transcription. (714 aa)
ENSPREP00000032744Retinoblastoma 1. (864 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (586 aa)
LOC103465526Melanocyte inducing transcription factor a. (404 aa)
akt1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
LOC103467856Tyrosine-protein kinase. (542 aa)
LOC103475214Hypoxia inducible factor 1 subunit alpha, like. (653 aa)
LOC103481975Uncharacterized protein. (191 aa)
thbs1Thrombospondin 1a. (1191 aa)
H3-3BHistone H3; Belongs to the histone H3 family. (138 aa)
ENSPREP00000027875Histone H3; Belongs to the histone H3 family. (96 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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