(10 nodes) (2022) High surface IgM levels associate with shorter response to ibrutinib and BTK bypass in patients with CLL. network (Poecilia reticulata)

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second shell of interactors

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Your Input:
	pxdn	Peroxidasin. (1463 aa)
	syk	Tyrosine-protein kinase. (614 aa)
	LOC103472843	Glyceraldehyde-3-phosphate dehydrogenase. (334 aa)
	LOC103468233	Tyrosine-protein kinase. (606 aa)
	gapdh	Glyceraldehyde-3-phosphate dehydrogenase. (333 aa)
	btk	Tyrosine-protein kinase. (637 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	mmut	Methylmalonyl CoA mutase. (464 aa)
	tyr	Tyrosinase. (545 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103468233	btk	ENSPREP00000012417	ENSPREP00000018757	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.506
LOC103472843	gapdh	ENSPREP00000001538	ENSPREP00000016134	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
LOC103472843	mmut	ENSPREP00000001538	ENSPREP00000021937	Glyceraldehyde-3-phosphate dehydrogenase.	Methylmalonyl CoA mutase.	0.423
LOC103472843	tp53	ENSPREP00000001538	ENSPREP00000019676	Glyceraldehyde-3-phosphate dehydrogenase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.419
btk	LOC103468233	ENSPREP00000018757	ENSPREP00000012417	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.506
btk	syk	ENSPREP00000018757	ENSPREP00000006334	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.506
gapdh	LOC103472843	ENSPREP00000016134	ENSPREP00000001538	Glyceraldehyde-3-phosphate dehydrogenase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.900
gapdh	mmut	ENSPREP00000016134	ENSPREP00000021937	Glyceraldehyde-3-phosphate dehydrogenase.	Methylmalonyl CoA mutase.	0.453
gapdh	pxdn	ENSPREP00000016134	ENSPREP00000005214	Glyceraldehyde-3-phosphate dehydrogenase.	Peroxidasin.	0.661
gapdh	tp53	ENSPREP00000016134	ENSPREP00000019676	Glyceraldehyde-3-phosphate dehydrogenase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.523
mmut	LOC103472843	ENSPREP00000021937	ENSPREP00000001538	Methylmalonyl CoA mutase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.423
mmut	gapdh	ENSPREP00000021937	ENSPREP00000016134	Methylmalonyl CoA mutase.	Glyceraldehyde-3-phosphate dehydrogenase.	0.453
mmut	pxdn	ENSPREP00000021937	ENSPREP00000005214	Methylmalonyl CoA mutase.	Peroxidasin.	0.429
mmut	tp53	ENSPREP00000021937	ENSPREP00000019676	Methylmalonyl CoA mutase.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.469
pxdn	gapdh	ENSPREP00000005214	ENSPREP00000016134	Peroxidasin.	Glyceraldehyde-3-phosphate dehydrogenase.	0.661
pxdn	mmut	ENSPREP00000005214	ENSPREP00000021937	Peroxidasin.	Methylmalonyl CoA mutase.	0.429
pxdn	tp53	ENSPREP00000005214	ENSPREP00000019676	Peroxidasin.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.605
syk	btk	ENSPREP00000006334	ENSPREP00000018757	Tyrosine-protein kinase.	Tyrosine-protein kinase.	0.506
tp53	LOC103472843	ENSPREP00000019676	ENSPREP00000001538	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.419
tp53	gapdh	ENSPREP00000019676	ENSPREP00000016134	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	Glyceraldehyde-3-phosphate dehydrogenase.	0.523