(15 nodes) (2022) Generation and Comparative Analysis of an Itga8-CreER T2 Mouse with Preferential Activity in Vascular Smooth Muscle Cells. network (Poecilia reticulata)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	TAGLN	Transgelin; Belongs to the calponin family. (202 aa)
	itga8	Integrin, alpha 8; Belongs to the integrin alpha chain family. (1045 aa)
	myocd	SAP domain-containing protein. (936 aa)
	polb	DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (337 aa)
	ARHGAP6-2	Rho GTPase activating protein 6. (707 aa)
	srf	Serum response factor b. (570 aa)
	LOC103474833	Transgelin; Belongs to the calponin family. (204 aa)
	SRF	Serum response factor. (243 aa)
	pdgfrb	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1040 aa)
	neb	Nebulin. (6138 aa)
	lck	Tyrosine-protein kinase. (500 aa)
	ARHGAP6	Rho GTPase activating protein 6. (507 aa)
	acta2	Uncharacterized protein; Belongs to the actin family. (233 aa)
	esr1	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. (621 aa)
	myh11	Myosin, heavy chain 11a, smooth muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1977 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103474833	acta2	ENSPREP00000011198	ENSPREP00000002428	Transgelin; Belongs to the calponin family.	Uncharacterized protein; Belongs to the actin family.	0.525
SRF	myocd	ENSPREP00000008765	ENSPREP00000026384	Serum response factor.	SAP domain-containing protein.	0.851
TAGLN	acta2	ENSPREP00000031782	ENSPREP00000002428	Transgelin; Belongs to the calponin family.	Uncharacterized protein; Belongs to the actin family.	0.525
acta2	LOC103474833	ENSPREP00000002428	ENSPREP00000011198	Uncharacterized protein; Belongs to the actin family.	Transgelin; Belongs to the calponin family.	0.525
acta2	TAGLN	ENSPREP00000002428	ENSPREP00000031782	Uncharacterized protein; Belongs to the actin family.	Transgelin; Belongs to the calponin family.	0.525
esr1	lck	ENSPREP00000006015	ENSPREP00000003459	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.472
lck	esr1	ENSPREP00000003459	ENSPREP00000006015	Tyrosine-protein kinase.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.472
lck	pdgfrb	ENSPREP00000003459	ENSPREP00000004019	Tyrosine-protein kinase.	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family.	0.583
myocd	SRF	ENSPREP00000026384	ENSPREP00000008765	SAP domain-containing protein.	Serum response factor.	0.851
myocd	srf	ENSPREP00000026384	ENSPREP00000012906	SAP domain-containing protein.	Serum response factor b.	0.851
pdgfrb	lck	ENSPREP00000004019	ENSPREP00000003459	Platelet-derived growth factor receptor, beta polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family.	Tyrosine-protein kinase.	0.583
srf	myocd	ENSPREP00000012906	ENSPREP00000026384	Serum response factor b.	SAP domain-containing protein.	0.851