(30 nodes) (2022) Determining epigenetic memory in kidney proximal tubule cell derived induced pluripotent stem cells using a quadruple transgenic reprogrammable mouse. network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	itga8	Integrin, alpha 8; Belongs to the integrin alpha chain family. (1045 aa)
	ENSPREP00000030771	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (65 aa)
	foxd1	Forkhead box D1. (321 aa)
	CDH6	Cadherin 6; Cadherins are calcium-dependent cell adhesion proteins. (799 aa)
	Sox2	SRY-box transcription factor 2. (246 aa)
	itgb1	Integrin beta; Belongs to the integrin beta chain family. (802 aa)
	cited1	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1. (143 aa)
	Lin28a	CCHC-type domain-containing protein. (202 aa)
	LOC103461301	Histone H3; Belongs to the histone H3 family. (90 aa)
	six2	SIX homeobox 2a. (290 aa)
	ENSPREP00000002301	Histone H3; Belongs to the histone H3 family. (92 aa)
	HIST2H3PS2	Histone H3; Belongs to the histone H3 family. (96 aa)
	fgf2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	sall1	Spalt-like transcription factor 1a. (1309 aa)
	jag1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1217 aa)
	bmp4	Bone morphogenetic protein 4. (480 aa)
	LOC103474858	Histone H3; Belongs to the histone H3 family. (138 aa)
	LOC103478373	ADAM metallopeptidase with thrombospondin type 1 motif, 16. (1187 aa)
	cd34	Uncharacterized protein. (211 aa)
	wt1	WT1 transcription factor b. (490 aa)
	pbx1	Homeobox domain-containing protein. (428 aa)
	CXCR4	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (392 aa)
	klf4	Uncharacterized protein. (442 aa)
	LOC103476384	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (79 aa)
	LOC103476847	Paired box 2a. (322 aa)
	gata3	GATA binding protein 3. (483 aa)
	eya1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
	actb	Uncharacterized protein. (375 aa)
	ENSPREP00000027875	Histone H3; Belongs to the histone H3 family. (96 aa)
	H3-3B	Histone H3; Belongs to the histone H3 family. (138 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CXCR4	cd34	ENSPREP00000021416	ENSPREP00000020181	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	Uncharacterized protein.	0.405
ENSPREP00000030771	fgf2	ENSPREP00000030771	ENSPREP00000009634	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.454
H3-3B	actb	ENSPREP00000028206	ENSPREP00000027111	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein.	0.479
LOC103474858	actb	ENSPREP00000012810	ENSPREP00000027111	Histone H3; Belongs to the histone H3 family.	Uncharacterized protein.	0.490
LOC103476384	fgf2	ENSPREP00000025882	ENSPREP00000009634	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.454
Sox2	klf4	ENSPREP00000033532	ENSPREP00000025010	SRY-box transcription factor 2.	Uncharacterized protein.	0.692
actb	H3-3B	ENSPREP00000027111	ENSPREP00000028206	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.479
actb	LOC103474858	ENSPREP00000027111	ENSPREP00000012810	Uncharacterized protein.	Histone H3; Belongs to the histone H3 family.	0.490
bmp4	fgf2	ENSPREP00000010205	ENSPREP00000009634	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.472
cd34	CXCR4	ENSPREP00000020181	ENSPREP00000021416	Uncharacterized protein.	C-X-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family.	0.405
cd34	fgf2	ENSPREP00000020181	ENSPREP00000009634	Uncharacterized protein.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.418
eya1	six2	ENSPREP00000026719	ENSPREP00000004863	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	SIX homeobox 2a.	0.703
fgf2	ENSPREP00000030771	ENSPREP00000009634	ENSPREP00000030771	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.454
fgf2	LOC103476384	ENSPREP00000009634	ENSPREP00000025882	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.454
fgf2	bmp4	ENSPREP00000009634	ENSPREP00000010205	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.472
fgf2	cd34	ENSPREP00000009634	ENSPREP00000020181	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Uncharacterized protein.	0.418
foxd1	wt1	ENSPREP00000030835	ENSPREP00000020243	Forkhead box D1.	WT1 transcription factor b.	0.518
itga8	itgb1	ENSPREP00000029861	ENSPREP00000008737	Integrin, alpha 8; Belongs to the integrin alpha chain family.	Integrin beta; Belongs to the integrin beta chain family.	0.931
itgb1	itga8	ENSPREP00000008737	ENSPREP00000029861	Integrin beta; Belongs to the integrin beta chain family.	Integrin, alpha 8; Belongs to the integrin alpha chain family.	0.931
klf4	Sox2	ENSPREP00000025010	ENSPREP00000033532	Uncharacterized protein.	SRY-box transcription factor 2.	0.692