(149 nodes) Helix loop helix domain network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	tfeb	Transcription factor EB. (522 aa)
	Ferd3l	Fer3-like bHLH transcription factor. (66 aa)
	twist1	Twist family bHLH transcription factor 1a. (182 aa)
	myog	Myogenin. (246 aa)
	LOC103458650	Oligodendrocyte transcription factor 4. (256 aa)
	NPAS3	Neuronal PAS domain protein 3. (1062 aa)
	atoh7	Atonal bHLH transcription factor 7. (133 aa)
	ENSPREP00000003149	BHLH domain-containing protein. (197 aa)
	arntl	Aryl hydrocarbon receptor nuclear translocator-like 1a. (602 aa)
	LOC103478556	BHLH domain-containing protein. (161 aa)
	ENSPREP00000002748	Myogenic factor. (237 aa)
	ENSPREP00000002654	BHLH domain-containing protein. (190 aa)
	LOC103466863	BHLH domain-containing protein. (221 aa)
	tcf15	Transcription factor 15. (181 aa)
	Tal1	BHLH domain-containing protein. (124 aa)
	TFAP4	Transcription factor AP-4. (317 aa)
	LOC103465449	Max interactor 1, dimerization protein. (278 aa)
	olig2	Oligodendrocyte lineage transcription factor 2. (273 aa)
	ENSPREP00000005434	BHLH domain-containing protein. (212 aa)
	LOC103461250	BHLH domain-containing protein. (330 aa)
	neurod1	Neurogenic differentiation factor. (353 aa)
	bhlha15	Basic helix-loop-helix family, member a15. (248 aa)
	LOC103460619	BHLH domain-containing protein. (451 aa)
	ENSPREP00000006666	BHLH domain-containing protein. (76 aa)
	LOC103458130	BHLH domain-containing protein. (3008 aa)
	MITF	Melanocyte inducing transcription factor b. (484 aa)
	LOC103457498	Mesogenin 1. (144 aa)
	helt	Helt bHLH transcription factor. (233 aa)
	mxd3	MAX dimerization protein 3. (200 aa)
	LOC103471118	BHLH domain-containing protein. (243 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1207 aa)
	mxd4	MAX dimerization protein 4. (214 aa)
	LOC103457471	MYCN proto-oncogene, bHLH transcription factor. (459 aa)
	ENSPREP00000009170	Endothelial PAS domain protein 1b. (814 aa)
	LOC103457458	Uncharacterized protein. (763 aa)
	myc	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (422 aa)
	hes1	Hairy-related 6. (277 aa)
	LOC103476645	Nescient helix loop helix 2. (124 aa)
	usf2	BHLH domain-containing protein. (327 aa)
	LOC103469919	T-cell acute lymphocytic leukemia 2. (112 aa)
	ascl1	Achaete-scute family bHLH transcription factor 1a. (200 aa)
	LOC103479094	Uncharacterized protein. (220 aa)
	NCOA3	Nuclear receptor coactivator. (1429 aa)
	EBF1	EBF transcription factor 1. (599 aa)
	LOC103469188	Transcription factor AP-4 (activating enhancer binding protein 4). (329 aa)
	hey1	Hes-related family bHLH transcription factor with YRPW motif 1. (331 aa)
	LOC103476073	BHLH domain-containing protein. (850 aa)
	LOC103463652	Transcription factor 3b. (634 aa)
	LOC103475635	MAX network transcriptional repressor b. (604 aa)
	npas4	Neuronal PAS domain protein 4a. (940 aa)
	LOC103462739	Mesoderm posterior aa. (232 aa)
	olig3	Oligodendrocyte transcription factor 3. (220 aa)
	ahrr	Uncharacterized protein. (682 aa)
	LOC103474874	Hairy-related 8.2. (199 aa)
	LOC103474875	Hairy-related 13. (298 aa)
	mlx	MAX dimerization protein MLX. (267 aa)
	ASCL4	Achaete-scute family bHLH transcription factor 4. (146 aa)
	ENSPREP00000015321	Myc associated factor X. (163 aa)
	tfec	Transcription factor EC. (403 aa)
	NEUROD2	Neurogenic differentiation factor. (356 aa)
	tcf21	Transcription factor 21. (175 aa)
	LOC103465907	Inhibitor of DNA binding 4. (150 aa)
	ptf1a	Pancreas associated transcription factor 1a. (267 aa)
	Bhlha9	Basic helix-loop-helix family, member a9. (294 aa)
	Neurog1	Neurogenin 1. (202 aa)
	LOC103471770	IPT/TIG domain-containing protein. (606 aa)
	ebf3	EBF transcription factor 3a. (547 aa)
	MXI1	MAX interactor 1, dimerization protein. (259 aa)
	LOC103468951	Uncharacterized protein. (908 aa)
	scx	Scleraxis bHLH transcription factor a. (215 aa)
	LOC103468369	BHLH domain-containing protein. (458 aa)
	usf1	Upstream transcription factor 1. (303 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (212 aa)
	LOC103457094	Uncharacterized protein. (238 aa)
	LOC103464779	Uncharacterized protein. (159 aa)
	LOC103464780	Uncharacterized protein. (162 aa)
	ENSPREP00000021491	BHLH domain-containing protein. (121 aa)
	LOC103464783	BHLH domain-containing protein. (164 aa)
	ENSPREP00000021513	BHLH domain-containing protein. (156 aa)
	LOC103466449	BHLH domain-containing protein. (495 aa)
	ARNTL2	Aryl hydrocarbon receptor nuclear translocator like 2. (527 aa)
	hes4	Hairy-related 9. (282 aa)
	BHLHE40	Basic helix-loop-helix family member e40. (428 aa)
	ENSPREP00000023031	Atonal bHLH transcription factor 1c. (150 aa)
	hif1a	Hypoxia inducible factor 1 subunit alpha a. (740 aa)
	LOC103482332	Uncharacterized protein. (963 aa)
	LOC103482321	Uncharacterized protein. (947 aa)
	neurod6	Neuronal differentiation 6b. (343 aa)
	TCF4	Transcription factor 4. (565 aa)
	ENSPREP00000024568	BHLH domain-containing protein. (197 aa)
	ENSPREP00000024873	Si:dkey-34f9.3. (139 aa)
	LOC103465377	BHLH domain-containing protein. (332 aa)
	LOC103460134	Twist2. (168 aa)
	HES2	Hes family bHLH transcription factor 2, tandem duplicate 1. (229 aa)
	HES2-2	Hes family bHLH transcription factor 2, tandem duplicate 1. (201 aa)
	mxd1	MAX dimerization protein 1. (222 aa)
	LOC103478724	Aryl hydrocarbon receptor nuclear translocator. (761 aa)
	LOC103479412	T-cell acute lymphocytic leukemia 1. (394 aa)
	SIM1	SIM bHLH transcription factor 1a. (740 aa)
	bhlhe23	Basic helix-loop-helix family, member e23. (227 aa)
	ncoa1	Nuclear receptor coactivator 1. (1196 aa)
	figla	Folliculogenesis specific bHLH transcription factor. (195 aa)
	LOC103466090	Aryl hydrocarbon receptor nuclear translocator-like 2. (636 aa)
	Msc	Musculin (activated B-cell factor-1). (148 aa)
	ENSPREP00000026835	Hairy-related 4, tandem duplicate 2. (159 aa)
	LOC103467258	Hairy-related 12. (148 aa)
	ncoa2	Nuclear receptor coactivator 2. (1521 aa)
	LOC103477588	Hairy and enhancer of split related-7. (219 aa)
	mycl	MYCL proto-oncogene, bHLH transcription factor b. (414 aa)
	atoh1	Atonal bHLH transcription factor 1a. (357 aa)
	bhlhe41	Basic helix-loop-helix family, member e41. (421 aa)
	LOC103462938	Myogenic factor. (271 aa)
	ENSPREP00000027951	Uncharacterized protein. (379 aa)
	usf3	Upstream transcription factor family member 3. (2250 aa)
	ENSPREP00000028461	Achaete-scute family bHLH transcription factor 1b. (177 aa)
	LOC103458857	Inhibitor of DNA binding 3. (116 aa)
	LOC103472123	Hes related family bHLH transcription factor with YRPW motif like. (316 aa)
	LOC103470973	EBF transcription factor 1. (494 aa)
	MAX	MYC associated factor X. (150 aa)
	bhlhe22	Basic helix-loop-helix family, member e22. (272 aa)
	CLOCK	Clock circadian regulator a. (833 aa)
	TCF24	Transcription factor 24. (179 aa)
	LOC103475214	Hypoxia inducible factor 1 subunit alpha, like. (653 aa)
	HEY1	Hes related family bHLH transcription factor with YRPW motif 1. (340 aa)
	LOC103464233	Myelocytomatosis oncogene homolog. (348 aa)
	mlxip	MLX interacting protein. (805 aa)
	LOC103475715	Neuronal PAS domain protein 2. (855 aa)
	ASCL5	Achaete-scute family bHLH transcription factor 5. (170 aa)
	LOC103465515	Basic helix-loop-helix family, member e40. (408 aa)
	LOC103467340	Neuronal differentiation 4. (356 aa)
	LOC103457262	Aryl hydrocarbon receptor 1b. (810 aa)
	LOC103457584	Aryl hydrocarbon receptor 2. (750 aa)
	LOC103465526	Melanocyte inducing transcription factor a. (404 aa)
	ebf2	EBF transcription factor 2. (573 aa)
	ENSPREP00000032411	Si:ch211-246m6.4. (204 aa)
	tfe3	Transcription factor binding to IGHM enhancer 3b. (490 aa)
	mnt	MAX network transcriptional repressor a. (558 aa)
	LOC103458578	MYCL proto-oncogene, bHLH transcription factor a. (362 aa)
	hand2	Heart and neural crest derivatives expressed 2. (226 aa)
	LOC103470963	Hairy-related 11. (276 aa)
	LOC103470962	Hairy-related 5. (194 aa)
	LOC103465574	Inhibitor of DNA binding 1, HLH protein. (127 aa)
	arnt2	Aryl-hydrocarbon receptor nuclear translocator 2. (679 aa)
	LOC103465576	Nuclear receptor coactivator 3. (1523 aa)
	myf5	Myogenic factor. (240 aa)
	myf6	Myogenic factor 6. (240 aa)
	Npas1	Neuronal PAS domain protein 1. (302 aa)
	LOC103481422	Neurogenic differentiation factor. (358 aa)
	tcf12	Transcription factor 12. (671 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARNTL2	CLOCK	ENSPREP00000022384	ENSPREP00000029360	Aryl hydrocarbon receptor nuclear translocator like 2.	Clock circadian regulator a.	0.808
ARNTL2	ENSPREP00000006666	ENSPREP00000022384	ENSPREP00000006666	Aryl hydrocarbon receptor nuclear translocator like 2.	BHLH domain-containing protein.	0.485
ARNTL2	ENSPREP00000009170	ENSPREP00000022384	ENSPREP00000009170	Aryl hydrocarbon receptor nuclear translocator like 2.	Endothelial PAS domain protein 1b.	0.558
ARNTL2	LOC103457262	ENSPREP00000022384	ENSPREP00000031672	Aryl hydrocarbon receptor nuclear translocator like 2.	Aryl hydrocarbon receptor 1b.	0.564
ARNTL2	LOC103457584	ENSPREP00000022384	ENSPREP00000031746	Aryl hydrocarbon receptor nuclear translocator like 2.	Aryl hydrocarbon receptor 2.	0.564
ARNTL2	LOC103468951	ENSPREP00000022384	ENSPREP00000018328	Aryl hydrocarbon receptor nuclear translocator like 2.	Uncharacterized protein.	0.808
ARNTL2	LOC103475214	ENSPREP00000022384	ENSPREP00000029852	Aryl hydrocarbon receptor nuclear translocator like 2.	Hypoxia inducible factor 1 subunit alpha, like.	0.558
ARNTL2	LOC103475715	ENSPREP00000022384	ENSPREP00000031107	Aryl hydrocarbon receptor nuclear translocator like 2.	Neuronal PAS domain protein 2.	0.808
ARNTL2	LOC103482321	ENSPREP00000022384	ENSPREP00000023389	Aryl hydrocarbon receptor nuclear translocator like 2.	Uncharacterized protein.	0.564
ARNTL2	LOC103482332	ENSPREP00000022384	ENSPREP00000023354	Aryl hydrocarbon receptor nuclear translocator like 2.	Uncharacterized protein.	0.564
ARNTL2	NPAS3	ENSPREP00000022384	ENSPREP00000004043	Aryl hydrocarbon receptor nuclear translocator like 2.	Neuronal PAS domain protein 3.	0.558
ARNTL2	Npas1	ENSPREP00000022384	ENSPREP00000033736	Aryl hydrocarbon receptor nuclear translocator like 2.	Neuronal PAS domain protein 1.	0.558
ARNTL2	SIM1	ENSPREP00000022384	ENSPREP00000026010	Aryl hydrocarbon receptor nuclear translocator like 2.	SIM bHLH transcription factor 1a.	0.418
ARNTL2	ahrr	ENSPREP00000022384	ENSPREP00000013279	Aryl hydrocarbon receptor nuclear translocator like 2.	Uncharacterized protein.	0.564
ARNTL2	bhlhe41	ENSPREP00000022384	ENSPREP00000027026	Aryl hydrocarbon receptor nuclear translocator like 2.	Basic helix-loop-helix family, member e41.	0.435
ARNTL2	hif1a	ENSPREP00000022384	ENSPREP00000023117	Aryl hydrocarbon receptor nuclear translocator like 2.	Hypoxia inducible factor 1 subunit alpha a.	0.558
ARNTL2	npas4	ENSPREP00000022384	ENSPREP00000013136	Aryl hydrocarbon receptor nuclear translocator like 2.	Neuronal PAS domain protein 4a.	0.809
ASCL4	Bhlha9	ENSPREP00000014000	ENSPREP00000017398	Achaete-scute family bHLH transcription factor 4.	Basic helix-loop-helix family, member a9.	0.549
ASCL4	LOC103463652	ENSPREP00000014000	ENSPREP00000012692	Achaete-scute family bHLH transcription factor 4.	Transcription factor 3b.	0.520
ASCL4	LOC103466449	ENSPREP00000014000	ENSPREP00000022020	Achaete-scute family bHLH transcription factor 4.	BHLH domain-containing protein.	0.489