(19 nodes) Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103474897	Si:dkey-76b14.2. (896 aa)
	madd	MAP-kinase activating death domain. (1673 aa)
	dennd2d	DENN/MADD domain containing 2Da. (584 aa)
	LOC103459495	UDENN domain-containing protein. (1094 aa)
	dennd4a	DENN/MADD domain containing 4A. (1685 aa)
	dennd2c	DENN/MADD domain containing 2C. (939 aa)
	dennd1a	DENN/MADD domain containing 1A. (996 aa)
	dennd3	DENN/MADD domain containing 3a. (1265 aa)
	dennd1b	DENN/MADD domain containing 1B. (864 aa)
	dennd4b	DENN/MADD domain containing 4B. (1236 aa)
	LOC103466070	DENN/MADD domain containing 5B. (1270 aa)
	sbf1	SET binding factor 1. (1960 aa)
	DENND4A	DENN domain containing 4A. (1603 aa)
	LOC103478638	UDENN domain-containing protein. (1198 aa)
	DENND2A	DENN domain containing 2A. (1045 aa)
	dennd4c	DENN/MADD domain containing 4C. (1779 aa)
	dennd2b	Suppression of tumorigenicity 5. (1110 aa)
	dennd5a	DENN/MADD domain containing 5A. (1265 aa)
	sbf2	SET binding factor 2. (1600 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC103474897	dennd1a	ENSPREP00000000462	ENSPREP00000017577	Si:dkey-76b14.2.	DENN/MADD domain containing 1A.	0.635
dennd1a	LOC103474897	ENSPREP00000017577	ENSPREP00000000462	DENN/MADD domain containing 1A.	Si:dkey-76b14.2.	0.635
dennd1a	dennd1b	ENSPREP00000017577	ENSPREP00000018159	DENN/MADD domain containing 1A.	DENN/MADD domain containing 1B.	0.634
dennd1a	madd	ENSPREP00000017577	ENSPREP00000005679	DENN/MADD domain containing 1A.	MAP-kinase activating death domain.	0.578
dennd1b	dennd1a	ENSPREP00000018159	ENSPREP00000017577	DENN/MADD domain containing 1B.	DENN/MADD domain containing 1A.	0.634
dennd1b	dennd2c	ENSPREP00000018159	ENSPREP00000016963	DENN/MADD domain containing 1B.	DENN/MADD domain containing 2C.	0.489
dennd2c	dennd1b	ENSPREP00000016963	ENSPREP00000018159	DENN/MADD domain containing 2C.	DENN/MADD domain containing 1B.	0.489
madd	dennd1a	ENSPREP00000005679	ENSPREP00000017577	MAP-kinase activating death domain.	DENN/MADD domain containing 1A.	0.578