STRINGSTRING
LOC103456889 LOC103456889 LOC103465407 LOC103465407 nt5c2 nt5c2 RRM1 RRM1 LOC103479509 LOC103479509 itpa itpa LOC103466224 LOC103466224 LOC103457562 LOC103457562 LOC103478583 LOC103478583 LOC103462567 LOC103462567 LOC103462569 LOC103462569 LOC103465677 LOC103465677 cant1 cant1 LOC103475915 LOC103475915 papss1 papss1 pfas pfas ADK ADK adcy5 adcy5 pde6g pde6g LOC103466890 LOC103466890 PDE3A PDE3A LOC103465759 LOC103465759 LOC103459907 LOC103459907 AMPD2 AMPD2 LOC103482172 LOC103482172 gucy1b1 gucy1b1 gucy1a1 gucy1a1 LOC103479018 LOC103479018 ENSPREP00000007515 ENSPREP00000007515 LOC103474780 LOC103474780 LOC103462680 LOC103462680 entpd1 entpd1 LOC103480256 LOC103480256 entpd4 entpd4 gart gart pgm2 pgm2 ak2 ak2 LOC103468725 LOC103468725 adcy6 adcy6 adcy7 adcy7 prps1 prps1 pde1b pde1b LOC103481584 LOC103481584 ADCY9 ADCY9 guk1 guk1 aprt aprt pde6a pde6a ak3 ak3 LOC103457410 LOC103457410 enpp4 enpp4 rrm2b rrm2b LOC103476686 LOC103476686 LOC103457375 LOC103457375 LOC103473654 LOC103473654 LOC103463403 LOC103463403 LOC103479174 LOC103479174 LOC103473675 LOC103473675 LOC103481184 LOC103481184 entpd5 entpd5 NT5C3B NT5C3B LOC103457335 LOC103457335 ak6 ak6 PDE7B PDE7B LOC103478370 LOC103478370 ampd1 ampd1 nt5e nt5e LOC103478359 LOC103478359 ak7 ak7 LOC103469013 LOC103469013 ENSPREP00000017807 ENSPREP00000017807 prps2 prps2 LOC103460982 LOC103460982 impdh2 impdh2 LOC108165778 LOC108165778 entpd6 entpd6 LOC103469615 LOC103469615 LOC103476794 LOC103476794 LOC103466012 LOC103466012 LOC103464157 LOC103464157 LOC103464790 LOC103464790 LOC103467180 LOC103467180 allc allc nme3 nme3 nudt9 nudt9 prune1 prune1 LOC103466051 LOC103466051 nudt5 nudt5 LOC103457894 LOC103457894 ENSPREP00000023514 ENSPREP00000023514 LOC103466422 LOC103466422 LOC103464121 LOC103464121 pde6h pde6h LOC103479836 LOC103479836 LOC103469155 LOC103469155 ak1 ak1 LOC103472033 LOC103472033 gmps gmps nme7 nme7 LOC103481041 LOC103481041 LOC103468453 LOC103468453 pde4d pde4d adprm adprm ak5 ak5 adcy3 adcy3 adsl adsl PDE2A PDE2A nme6 nme6 nt5c3a nt5c3a urad urad pde7a pde7a atic atic LOC103476524 LOC103476524 ppat ppat LOC103463823 LOC103463823 ak4 ak4 pde6d pde6d LOC103481179 LOC103481179 pgm1 pgm1 ada ada dck dck adcy8 adcy8 nudt2 nudt2 GUCY1A2 GUCY1A2 pde1a pde1a LOC103458543 LOC103458543 LOC103472797 LOC103472797 pde5a pde5a NT5M NT5M LOC103476980 LOC103476980 LOC103458579 LOC103458579 LOC103467316 LOC103467316 ENSPREP00000032789 ENSPREP00000032789 hprt1 hprt1 Pde9a Pde9a pde6c pde6c LOC103459168 LOC103459168 pde3b pde3b ampd3 ampd3 pde10a pde10a
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
protein homology
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LOC103456889Phosphodiesterase. (874 aa)
LOC103465407Calcium activated nucleotidase 1b. (408 aa)
nt5c25'-nucleotidase, cytosolic IIb. (558 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (795 aa)
LOC103479509Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
itpaInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (195 aa)
LOC103466224Purine nucleoside phosphorylase 6. (520 aa)
LOC103457562Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1185 aa)
LOC103478583Phosphodiesterase. (849 aa)
LOC1034625675-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (132 aa)
LOC1034625695-hydroxyisourate hydrolase; Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (121 aa)
LOC103465677Guanylate cyclase. (954 aa)
cant1Calcium activated nucleotidase 1a. (425 aa)
LOC103475915Purine nucleoside phosphorylase 5a. (335 aa)
papss13'-phosphoadenosine 5'-phosphosulfate synthase 1. (657 aa)
pfasPhosphoribosylformylglycinamidine synthase. (1320 aa)
ADKAdenosine kinase. (301 aa)
adcy5Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1213 aa)
pde6gPhosphodiesterase 6G, cGMP-specific, rod, gamma, paralog a. (90 aa)
LOC103466890Zgc:103759. (252 aa)
PDE3APhosphodiesterase. (1013 aa)
LOC103465759AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (641 aa)
LOC103459907Zgc:110540. (260 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (943 aa)
LOC103482172Nucleoside diphosphate kinase. (153 aa)
gucy1b1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (621 aa)
gucy1a1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (678 aa)
LOC103479018Phosphodiesterase. (758 aa)
ENSPREP00000007515Uncharacterized protein. (63 aa)
LOC103474780Guanylate cyclase. (1100 aa)
LOC103462680Pyruvate kinase; Belongs to the pyruvate kinase family. (607 aa)
entpd1Ectonucleoside triphosphate diphosphohydrolase 1; Belongs to the GDA1/CD39 NTPase family. (498 aa)
LOC103480256Guanylate cyclase. (1136 aa)
entpd4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (618 aa)
gartTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (1010 aa)
pgm2Phosphoglucomutase 2. (611 aa)
ak2Adenylate kinase 2, mitochondrial; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. (243 aa)
LOC103468725Phosphodiesterase. (746 aa)
adcy6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1172 aa)
adcy7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
prps1Phosphoribosyl pyrophosphate synthetase 1B. (320 aa)
pde1bPhosphodiesterase. (519 aa)
LOC103481584Phosphodiesterase 6G, cGMP-specific, rod, gamma, paralog b. (80 aa)
ADCY9Adenylate cyclase 9; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (1439 aa)
guk1Guanylate kinase 1a. (211 aa)
aprtAdenine phosphoribosyltransferase. (180 aa)
pde6aPhosphodiesterase. (873 aa)
ak3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (223 aa)
LOC103457410Ectonucleotide pyrophosphatase/phosphodiesterase 1. (834 aa)
enpp4Ectonucleotide pyrophosphatase/phosphodiesterase 4. (455 aa)
rrm2bRibonucleotide reductase M2 b. (354 aa)
LOC103476686Adenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (457 aa)
LOC1034573755'-nucleotidase, cytosolic IB b. (367 aa)
LOC103473654Phosphodiesterase. (854 aa)
LOC103463403Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1126 aa)
LOC103479174Phosphodiesterase. (782 aa)
LOC1034736755'-nucleotidase, cytosolic II, like 1. (505 aa)
LOC103481184Adenylate cyclase; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1181 aa)
entpd5Ectonucleoside triphosphate diphosphohydrolase 5a; Belongs to the GDA1/CD39 NTPase family. (496 aa)
NT5C3B5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (280 aa)
LOC103457335Uncharacterized protein. (715 aa)
ak6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (173 aa)
PDE7BPhosphodiesterase. (528 aa)
LOC103478370Adenylate cyclase 2a; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (847 aa)
ampd1AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (726 aa)
nt5e5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (647 aa)
LOC103478359Ectonucleoside triphosphate diphosphohydrolase 3; Belongs to the GDA1/CD39 NTPase family. (480 aa)
ak7Adenylate kinase 7b. (699 aa)
LOC103469013NDK domain-containing protein; Belongs to the NDK family. (149 aa)
ENSPREP00000017807Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (233 aa)
prps2Pribosyltran_N domain-containing protein. (318 aa)
LOC103460982Phosphoribosyl pyrophosphate synthetase 2. (209 aa)
impdh2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (521 aa)
LOC108165778Uncharacterized protein. (73 aa)
entpd6Ectonucleoside triphosphate diphosphohydrolase 6; Belongs to the GDA1/CD39 NTPase family. (429 aa)
LOC103469615Ectonucleoside triphosphate diphosphohydrolase 2a, tandem duplicate 2; Belongs to the GDA1/CD39 NTPase family. (493 aa)
LOC1034767943'-phosphoadenosine 5'-phosphosulfate synthase 2a. (614 aa)
LOC103466012Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (626 aa)
LOC103464157Uricase; Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. Belongs to the uricase family. (299 aa)
LOC103464790Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
LOC103467180AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (835 aa)
allcAllantoicase. (382 aa)
nme3Nucleoside diphosphate kinase. (180 aa)
nudt9Nudix (nucleoside diphosphate linked moiety X)-type motif 9. (338 aa)
prune1Prune exopolyphosphatase. (414 aa)
LOC103466051Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (238 aa)
nudt5Nudix (nucleoside diphosphate linked moiety X)-type motif 5. (218 aa)
LOC103457894Ectonucleoside triphosphate diphosphohydrolase 5b; Belongs to the GDA1/CD39 NTPase family. (427 aa)
ENSPREP00000023514PNP_UDP_1 domain-containing protein. (96 aa)
LOC103466422Pyruvate kinase; Belongs to the pyruvate kinase family. (530 aa)
LOC103464121Guanylate kinase 1b. (233 aa)
pde6hUncharacterized protein. (86 aa)
LOC103479836Phosphodiesterase. (636 aa)
LOC103469155Nucleoside diphosphate kinase. (236 aa)
ak1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (200 aa)
LOC1034720335'-nucleotidase, cytosolic IAa. (387 aa)
gmpsGuanine monophosphate synthase. (690 aa)
nme7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (379 aa)
LOC103481041Guanylate cyclase. (1031 aa)
LOC103468453Guanylate cyclase. (1083 aa)
pde4dPhosphodiesterase. (787 aa)
adprmADP-ribose/CDP-alcohol diphosphatase, manganese-dependent. (323 aa)
ak5Adenylate kinase 5; Belongs to the adenylate kinase family. (562 aa)
adcy3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1121 aa)
adslAdenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (481 aa)
PDE2APhosphodiesterase. (965 aa)
nme6Nucleoside diphosphate kinase. (182 aa)
nt5c3a5'-nucleotidase; Belongs to the pyrimidine 5'-nucleotidase family. (331 aa)
uradUreidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase. (174 aa)
pde7aPhosphodiesterase. (506 aa)
atic5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. (591 aa)
LOC1034765245'-nucleotidase, cytosolic IIa. (573 aa)
ppatAmidophosphoribosyltransferase; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (502 aa)
LOC103463823AIRC domain-containing protein. (1012 aa)
ak4Adenylate kinase 4; Belongs to the adenylate kinase family. (190 aa)
pde6d60S ribosomal protein L36; Belongs to the eukaryotic ribosomal protein eL36 family. (276 aa)
LOC103481179Adenosine deaminase 2a. (516 aa)
pgm1Phosphoglucomutase 1; Belongs to the phosphohexose mutase family. (561 aa)
adaAdenosine deaminase. (399 aa)
dckDeoxycytidine kinase. (263 aa)
adcy8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1239 aa)
nudt2Nudix (nucleoside diphosphate linked moiety X)-type motif 2. (147 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (807 aa)
pde1aPhosphodiesterase. (691 aa)
LOC103458543Adenylosuccinate synthetase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (466 aa)
LOC103472797Uncharacterized protein. (1066 aa)
pde5aPhosphodiesterase. (817 aa)
NT5M5',3'-nucleotidase, mitochondrial. (230 aa)
LOC103476980Adenosine kinase a. (371 aa)
LOC1034585795'-nucleotidase, cytosolic IAb. (366 aa)
LOC103467316Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1179 aa)
ENSPREP00000032789RIBORED_LARGE domain-containing protein. (82 aa)
hprt1Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (218 aa)
Pde9aPhosphodiesterase 9A like; Belongs to the cyclic nucleotide phosphodiesterase family. (276 aa)
pde6cPhosphodiesterase. (853 aa)
LOC103459168Adenosine deaminase 2b. (485 aa)
pde3bPhosphodiesterase. (1096 aa)
ampd3Adenosine monophosphate deaminase 3a. (617 aa)
pde10aPhosphodiesterase. (807 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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