(39 nodes) Nicotinate and nicotinamide metabolism network (Poecilia reticulata)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	nt5c2	5'-nucleotidase, cytosolic IIb. (558 aa)
	LOC103479509	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
	LOC103466224	Purine nucleoside phosphorylase 6. (520 aa)
	sirt4	NAD-dependent protein deacylase; NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues; Belongs to the sirtuin family. Class II subfamily. (311 aa)
	LOC103475915	Purine nucleoside phosphorylase 5a. (335 aa)
	sirt1	Sirtuin 1. (677 aa)
	QPRT	Nicotinate-nucleotide pyrophosphorylase [carboxylating]; Involved in the catabolism of quinolinic acid (QA). Belongs to the NadC/ModD family. (296 aa)
	nadk2	NAD kinase 2, mitochondrial; Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor. (433 aa)
	LOC103457410	Ectonucleotide pyrophosphatase/phosphodiesterase 1. (834 aa)
	LOC103462093	Muscle-specific beta 1 integrin binding protein 2. (206 aa)
	LOC103462087	Nicotinamide nucleotide transhydrogenase 2. (1014 aa)
	sirt2	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (385 aa)
	LOC103457375	5'-nucleotidase, cytosolic IB b. (367 aa)
	naprt	Nicotinate phosphoribosyltransferase. (608 aa)
	LOC103473658	Nicotinamide nucleotide transhydrogenase. (1096 aa)
	sirt5	NAD-dependent protein deacylase sirtuin-5, mitochondrial; NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. (326 aa)
	LOC103473675	5'-nucleotidase, cytosolic II, like 1. (505 aa)
	nadk	NAD kinase a. (361 aa)
	nampt	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
	nt5e	5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (647 aa)
	LOC103479788	Nicotinamide riboside kinase 2. (202 aa)
	LOC103479795	NAD kinase b. (491 aa)
	aspdh	Aspartate dehydrogenase domain containing. (278 aa)
	LOC103479319	Nicotinamide-nucleotide adenylyltransferase. (265 aa)
	LOC103464790	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (296 aa)
	LOC103470104	Nicotinamide riboside kinase 1. (224 aa)
	nmnat1	Nicotinamide-nucleotide adenylyltransferase. (285 aa)
	ENSPREP00000023514	PNP_UDP_1 domain-containing protein. (96 aa)
	LOC103472033	5'-nucleotidase, cytosolic IAa. (387 aa)
	LOC103466083	Si:dkey-103i16.6. (445 aa)
	LOC103464095	Uncharacterized protein. (197 aa)
	LOC103479463	Sirtuin 6. (339 aa)
	nmnat2	Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
	LOC103476524	5'-nucleotidase, cytosolic IIa. (573 aa)
	LOC103465472	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (494 aa)
	LOC103472797	Uncharacterized protein. (1066 aa)
	NT5M	5',3'-nucleotidase, mitochondrial. (230 aa)
	aox1	Uncharacterized protein. (1331 aa)
	LOC103458579	5'-nucleotidase, cytosolic IAb. (366 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPREP00000023514	LOC103457375	ENSPREP00000023514	ENSPREP00000013559	PNP_UDP_1 domain-containing protein.	5'-nucleotidase, cytosolic IB b.	0.706
ENSPREP00000023514	LOC103458579	ENSPREP00000023514	ENSPREP00000032566	PNP_UDP_1 domain-containing protein.	5'-nucleotidase, cytosolic IAb.	0.706
ENSPREP00000023514	LOC103462093	ENSPREP00000023514	ENSPREP00000012341	PNP_UDP_1 domain-containing protein.	Muscle-specific beta 1 integrin binding protein 2.	0.710
ENSPREP00000023514	LOC103464095	ENSPREP00000023514	ENSPREP00000025979	PNP_UDP_1 domain-containing protein.	Uncharacterized protein.	0.710
ENSPREP00000023514	LOC103464790	ENSPREP00000023514	ENSPREP00000021587	PNP_UDP_1 domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.902
ENSPREP00000023514	LOC103465472	ENSPREP00000023514	ENSPREP00000030128	PNP_UDP_1 domain-containing protein.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.907
ENSPREP00000023514	LOC103466083	ENSPREP00000023514	ENSPREP00000025749	PNP_UDP_1 domain-containing protein.	Si:dkey-103i16.6.	0.678
ENSPREP00000023514	LOC103466224	ENSPREP00000023514	ENSPREP00000001296	PNP_UDP_1 domain-containing protein.	Purine nucleoside phosphorylase 6.	0.902
ENSPREP00000023514	LOC103470104	ENSPREP00000023514	ENSPREP00000021750	PNP_UDP_1 domain-containing protein.	Nicotinamide riboside kinase 1.	0.740
ENSPREP00000023514	LOC103472033	ENSPREP00000023514	ENSPREP00000024584	PNP_UDP_1 domain-containing protein.	5'-nucleotidase, cytosolic IAa.	0.706
ENSPREP00000023514	LOC103473675	ENSPREP00000023514	ENSPREP00000015035	PNP_UDP_1 domain-containing protein.	5'-nucleotidase, cytosolic II, like 1.	0.734
ENSPREP00000023514	LOC103475915	ENSPREP00000023514	ENSPREP00000003576	PNP_UDP_1 domain-containing protein.	Purine nucleoside phosphorylase 5a.	0.903
ENSPREP00000023514	LOC103476524	ENSPREP00000023514	ENSPREP00000029683	PNP_UDP_1 domain-containing protein.	5'-nucleotidase, cytosolic IIa.	0.734
ENSPREP00000023514	LOC103479319	ENSPREP00000023514	ENSPREP00000020926	PNP_UDP_1 domain-containing protein.	Nicotinamide-nucleotide adenylyltransferase.	0.502
ENSPREP00000023514	LOC103479463	ENSPREP00000023514	ENSPREP00000026036	PNP_UDP_1 domain-containing protein.	Sirtuin 6.	0.678
ENSPREP00000023514	LOC103479509	ENSPREP00000023514	ENSPREP00000001055	PNP_UDP_1 domain-containing protein.	Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.	0.903
ENSPREP00000023514	LOC103479788	ENSPREP00000023514	ENSPREP00000019573	PNP_UDP_1 domain-containing protein.	Nicotinamide riboside kinase 2.	0.710
ENSPREP00000023514	NT5M	ENSPREP00000023514	ENSPREP00000032012	PNP_UDP_1 domain-containing protein.	5',3'-nucleotidase, mitochondrial.	0.850
ENSPREP00000023514	aox1	ENSPREP00000023514	ENSPREP00000032151	PNP_UDP_1 domain-containing protein.	Uncharacterized protein.	0.536
ENSPREP00000023514	nampt	ENSPREP00000023514	ENSPREP00000017169	PNP_UDP_1 domain-containing protein.	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family.	0.916