STRINGSTRING
mad1l1 mad1l1 smc3 smc3 gsk3b gsk3b GADD45B GADD45B anapc13 anapc13 e2f4 e2f4 LOC103466812 LOC103466812 Cdc14a Cdc14a e2f1 e2f1 ENSPREP00000001990 ENSPREP00000001990 LOC103458631 LOC103458631 ccnd1 ccnd1 LOC103472890 LOC103472890 LOC103467726 LOC103467726 anapc10 anapc10 ccne1 ccne1 cdc20 cdc20 cdk6 cdk6 anapc11 anapc11 LOC103465732 LOC103465732 wee1 wee1 LOC103465183 LOC103465183 ccnh ccnh Ccnd3 Ccnd3 LOC103460619 LOC103460619 skp1 skp1 anapc2 anapc2 cdc16 cdc16 cdkn2b cdkn2b CDC25B CDC25B cdk1 cdk1 ccna2 ccna2 bub3 bub3 crebbp crebbp cdc7 cdc7 LOC103476068 LOC103476068 SMAD3 SMAD3 gadd45a gadd45a mcm4 mcm4 LOC103474138 LOC103474138 LOC103469340 LOC103469340 ywhae ywhae ENSPREP00000013852 ENSPREP00000013852 tgfb3 tgfb3 tfdp1 tfdp1 Zbtb17 Zbtb17 mad2l2 mad2l2 LOC103466539 LOC103466539 LOC103472446 LOC103472446 GADD45B-2 GADD45B-2 cul1 cul1 LOC103469079 LOC103469079 atr atr ccna1 ccna1 LOC103465909 LOC103465909 stag1 stag1 cdc45 cdc45 pcna pcna pttg1 pttg1 LOC103465931 LOC103465931 LOC103478347 LOC103478347 cdc27 cdc27 tp53 tp53 ENSPREP00000020452 ENSPREP00000020452 LOC103473773 LOC103473773 cdkn2d cdkn2d LOC103463991 LOC103463991 mcm7 mcm7 Stag3 Stag3 Bub1 Bub1 cdk2 cdk2 abl1 abl1 cdk4 cdk4 Mcm5 Mcm5 LOC103477474 LOC103477474 ttk ttk tgfb2 tgfb2 YWHAB YWHAB LOC103470128 LOC103470128 anapc7 anapc7 dbf4 dbf4 gadd45g gadd45g chek2 chek2 espl1 espl1 atm atm LOC103472045 LOC103472045 LOC103469777 LOC103469777 chek1 chek1 FZR1 FZR1 rbx1 rbx1 LOC103468460 LOC103468460 LOC103475119 LOC103475119 ccne2 ccne2 ywhaq ywhaq anapc4 anapc4 LOC103464190 LOC103464190 mcm3 mcm3 e2f2 e2f2 TGFB3 TGFB3 ccnb1 ccnb1 anapc5 anapc5 wee2 wee2 LOC103464233 LOC103464233 LOC103482005 LOC103482005 orc3 orc3 HDAC2 HDAC2 LOC103470908 LOC103470908 mcm6 mcm6 orc2 orc2 mad2l1 mad2l1 LOC103475746 LOC103475746 smc1a smc1a bub1b bub1b cdc6 cdc6 orc4 orc4 ENSPREP00000032744 ENSPREP00000032744 LOC103464293 LOC103464293 mcm2 mcm2 LOC103459164 LOC103459164 cdc23 cdc23
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mad1l1Mitotic arrest deficient 1 like 1. (719 aa)
smc3Structural maintenance of chromosomes protein. (1225 aa)
gsk3bGlycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
GADD45BGrowth arrest and DNA damage inducible beta. (160 aa)
anapc13Anaphase promoting complex subunit 13. (74 aa)
e2f4E2F transcription factor 4. (384 aa)
LOC103466812Cyclin D2, a; Belongs to the cyclin family. (355 aa)
Cdc14aUncharacterized protein. (135 aa)
e2f1E2F transcription factor 1. (477 aa)
ENSPREP00000001990Growth arrest and DNA-damage-inducible, gamma b, tandem duplicate 1. (139 aa)
LOC103458631Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (488 aa)
ccnd1Cyclin D1; Belongs to the cyclin family. (292 aa)
LOC103472890RAD21 cohesin complex component b. (644 aa)
LOC103467726RAD21 cohesin complex component like 1. (539 aa)
anapc10Anaphase promoting complex subunit 10. (184 aa)
ccne1Cyclin E1; Belongs to the cyclin family. (434 aa)
cdc20Cell division cycle 20 homolog. (555 aa)
cdk6Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily. (325 aa)
anapc11APC11 anaphase promoting complex subunit 11 homolog (yeast). (84 aa)
LOC103465732Structural maintenance of chromosomes protein. (1250 aa)
wee1Wee1-like protein kinase. (620 aa)
LOC103465183Cyclin-dependent kinase inhibitor 1A. (156 aa)
ccnhCyclin H; Belongs to the cyclin family. (319 aa)
Ccnd3Cyclin D3; Belongs to the cyclin family. (198 aa)
LOC103460619BHLH domain-containing protein. (451 aa)
skp1S-phase kinase-associated protein 1; Belongs to the SKP1 family. (107 aa)
anapc2Anaphase promoting complex subunit 2; Belongs to the cullin family. (742 aa)
cdc16Cell division cycle 16 homolog (S. cerevisiae). (618 aa)
cdkn2bCyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (126 aa)
CDC25BCell division cycle 25B. (383 aa)
cdk1Cyclin-dependent kinase 1; Belongs to the protein kinase superfamily. (308 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (434 aa)
bub3BUB3 mitotic checkpoint protein. (326 aa)
crebbpCREB binding protein b. (2452 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (610 aa)
LOC1034760683-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 1; Belongs to the 14-3-3 family. (247 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
gadd45aGrowth arrest and DNA-damage-inducible, alpha, a. (162 aa)
mcm4DNA helicase; Belongs to the MCM family. (880 aa)
LOC1034741383-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide 2; Belongs to the 14-3-3 family. (247 aa)
LOC103469340Cyclin-dependent kinase 21; Belongs to the protein kinase superfamily. (289 aa)
ywhaeTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide 1; Belongs to the 14-3-3 family. (255 aa)
ENSPREP00000013852Uncharacterized protein. (148 aa)
tgfb3Transforming growth factor beta; Belongs to the TGF-beta family. (408 aa)
tfdp1Transcription factor. (410 aa)
Zbtb17Zinc finger and BTB domain containing 17. (491 aa)
mad2l2Mitotic arrest deficient 2 like 2. (192 aa)
LOC103466539Mothers against decapentaplegic homolog. (425 aa)
LOC103472446Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; Belongs to the 14-3-3 family. (250 aa)
GADD45B-2Growth arrest and DNA damage inducible beta. (195 aa)
cul1Cullin 1b; Belongs to the cullin family. (776 aa)
LOC103469079Cyclin Dx; Belongs to the cyclin family. (295 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2589 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (402 aa)
LOC103465909Cyclin-dependent kinase inhibitor 1Bb. (194 aa)
stag1Stromal antigen 1a. (1260 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (573 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pttg1Uncharacterized protein. (177 aa)
LOC103465931Cyclin-dependent kinase inhibitor 1Cb. (217 aa)
LOC103478347RAD21 cohesin complex component a. (637 aa)
cdc27Cell division cycle 27. (803 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (342 aa)
ENSPREP00000020452E2F_TDP domain-containing protein. (155 aa)
LOC103473773Mothers against decapentaplegic homolog. (503 aa)
cdkn2dCyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4). (164 aa)
LOC103463991Growth arrest and DNA-damage-inducible, alpha, b. (245 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (541 aa)
Stag3SCD domain-containing protein. (116 aa)
Bub1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (210 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
abl1Tyrosine-protein kinase. (1124 aa)
cdk4Cyclin-dependent kinase 4. (228 aa)
Mcm5Uncharacterized protein. (58 aa)
LOC103477474Mothers against decapentaplegic homolog. (534 aa)
ttkTtk protein kinase. (996 aa)
tgfb2Transforming growth factor beta; Belongs to the TGF-beta family. (414 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide b; Belongs to the 14-3-3 family. (307 aa)
LOC103470128Cell division cycle 14B. (525 aa)
anapc7Anaphase promoting complex subunit 7. (565 aa)
dbf4DBF4 zinc finger. (593 aa)
gadd45gGrowth arrest and DNA-damage-inducible, gamma a. (159 aa)
chek2Checkpoint kinase 2. (510 aa)
espl1Extra spindle pole bodies like 1, separase. (2165 aa)
atmNon-specific serine/threonine protein kinase. (3091 aa)
LOC103472045Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (482 aa)
LOC103469777Mothers against decapentaplegic homolog. (467 aa)
chek1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (478 aa)
FZR1Fizzy/cell division cycle 20 related 1a. (470 aa)
rbx1Ring-box 1, E3 ubiquitin protein ligase. (108 aa)
LOC103468460E1A binding protein p300 b. (2737 aa)
LOC103475119Transforming growth factor beta; Belongs to the TGF-beta family. (380 aa)
ccne2Cyclin E2; Belongs to the cyclin family. (394 aa)
ywhaqTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide b; Belongs to the 14-3-3 family. (284 aa)
anapc4Anaphase-promoting complex subunit 4; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. Belongs to the APC4 family. (802 aa)
LOC103464190ANK_REP_REGION domain-containing protein. (161 aa)
mcm3DNA helicase; Belongs to the MCM family. (814 aa)
e2f2Si:ch211-160f23.5. (449 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (407 aa)
ccnb1Cyclin B1; Belongs to the cyclin family. (401 aa)
anapc5Anaphase promoting complex subunit 5. (773 aa)
wee2Wee1-like protein kinase. (527 aa)
LOC103464233Myelocytomatosis oncogene homolog. (348 aa)
LOC103482005E1A binding protein p300 a. (2743 aa)
orc3Origin recognition complex, subunit 3. (723 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (458 aa)
LOC103470908Stromal antigen 2b. (1272 aa)
mcm6DNA helicase; Belongs to the MCM family. (825 aa)
orc2Origin recognition complex, subunit 2. (578 aa)
mad2l1MAD2 mitotic arrest deficient-like 1 (yeast). (202 aa)
LOC103475746Stromal antigen 2a. (1295 aa)
smc1aStructural maintenance of chromosomes protein. (1231 aa)
bub1bBUB1 mitotic checkpoint serine/threonine kinase Bb. (427 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (586 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
ENSPREP00000032744Retinoblastoma 1. (864 aa)
LOC10346429314_3_3 domain-containing protein; Belongs to the 14-3-3 family. (244 aa)
mcm2DNA helicase; Belongs to the MCM family. (887 aa)
LOC103459164Cyclin D2, b; Belongs to the cyclin family. (294 aa)
cdc23CDC23 (cell division cycle 23, yeast, homolog). (575 aa)
Your Current Organism:
Poecilia reticulata
NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy
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