(64 nodes) VEGF signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC103479675	Rac family small GTPase 2. (192 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (688 aa)
	LOC103462977	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (666 aa)
	plcg2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1260 aa)
	ppp3r1	Uncharacterized protein. (170 aa)
	LOC103472837	Uncharacterized protein. (196 aa)
	LOC103466877	Mitogen-activated protein kinase. (364 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC103464907	Mitogen-activated protein kinase. (363 aa)
	pik3r3	Uncharacterized protein. (474 aa)
	LOC103482188	Rac family small GTPase 3b. (203 aa)
	LOC103464872	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily. (376 aa)
	CDC42	Cell division cycle 42. (191 aa)
	LOC103471056	Serine/threonine-protein phosphatase. (511 aa)
	LOC103478998	Uncharacterized protein. (512 aa)
	LOC103472014	Uncharacterized protein. (209 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	RAC1	Rac family small GTPase 1. (192 aa)
	pla2g4c	Zgc:101699. (580 aa)
	hspb1	Heat shock protein, alpha-crystallin-related, 1; Belongs to the small heat shock protein (HSP20) family. (200 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC103478059	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (669 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	ptgs2	Prostaglandin-endoperoxide synthase 2b. (615 aa)
	pla2g4a	Phospholipase A2. (749 aa)
	LOC103463411	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1309 aa)
	LOC103467000	Mitogen-activated protein kinase. (366 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (701 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	SRC	Tyrosine-protein kinase. (569 aa)
	ENSPREP00000016362	RHD domain-containing protein. (616 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (715 aa)
	LOC103463319	Uncharacterized protein. (406 aa)
	LOC103477991	Uncharacterized protein. (191 aa)
	MAPKAPK3	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (423 aa)
	vegfa	Vascular endothelial growth factor Ab; Belongs to the PDGF/VEGF growth factor family. (214 aa)
	LOC103473747	Heat shock protein, alpha-crystallin-related, b15; Belongs to the small heat shock protein (HSP20) family. (199 aa)
	LOC103473147	Serine/threonine-protein phosphatase. (511 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	casp9	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (427 aa)
	LOC103469088	Zgc:55558. (191 aa)
	LOC103469549	Serine/threonine-protein phosphatase. (506 aa)
	LOC103469111	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	SPHK1	Sphingosine kinase 1. (564 aa)
	LOC103465075	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily. (413 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	plcg1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1271 aa)
	LOC103475446	Serine/threonine-protein phosphatase. (522 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (683 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1357 aa)
	LOC103480722	Serine/threonine-protein phosphatase. (458 aa)
	LOC103481975	Uncharacterized protein. (191 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC103467856	Tyrosine-protein kinase. (542 aa)
	nfatc2	Nuclear factor of activated T cells 2a. (899 aa)
	LOC103466203	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
	LOC103467285	Mitogen-activated protein kinase. (347 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDC42	LOC103463411	ENSPREP00000005959	ENSPREP00000013501	Cell division cycle 42.	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades.	0.418
CDC42	LOC103464872	ENSPREP00000005959	ENSPREP00000005554	Cell division cycle 42.	MAPK activated protein kinase 2a; Belongs to the protein kinase superfamily.	0.516
CDC42	LOC103464907	ENSPREP00000005959	ENSPREP00000003478	Cell division cycle 42.	Mitogen-activated protein kinase.	0.941
CDC42	LOC103465075	ENSPREP00000005959	ENSPREP00000025755	Cell division cycle 42.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.463
CDC42	LOC103466203	ENSPREP00000005959	ENSPREP00000031228	Cell division cycle 42.	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.	0.941
CDC42	LOC103466877	ENSPREP00000005959	ENSPREP00000003114	Cell division cycle 42.	Mitogen-activated protein kinase.	0.941
CDC42	LOC103467000	ENSPREP00000005959	ENSPREP00000013869	Cell division cycle 42.	Mitogen-activated protein kinase.	0.941
CDC42	LOC103467285	ENSPREP00000005959	ENSPREP00000033561	Cell division cycle 42.	Mitogen-activated protein kinase.	0.941
CDC42	LOC103467856	ENSPREP00000005959	ENSPREP00000031006	Cell division cycle 42.	Tyrosine-protein kinase.	0.500
CDC42	LOC103470003	ENSPREP00000005959	ENSPREP00000030956	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103472837	ENSPREP00000005959	ENSPREP00000001820	Cell division cycle 42.	Uncharacterized protein.	0.900
CDC42	LOC103474789	ENSPREP00000005959	ENSPREP00000008269	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103475907	ENSPREP00000005959	ENSPREP00000003309	Cell division cycle 42.	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.624
CDC42	LOC103476681	ENSPREP00000005959	ENSPREP00000012589	Cell division cycle 42.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.419
CDC42	LOC103477991	ENSPREP00000005959	ENSPREP00000017385	Cell division cycle 42.	Uncharacterized protein.	0.901
CDC42	LOC103479066	ENSPREP00000005959	ENSPREP00000009342	Cell division cycle 42.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.624
CDC42	LOC103479675	ENSPREP00000005959	ENSPREP00000000205	Cell division cycle 42.	Rac family small GTPase 2.	0.520
CDC42	LOC103481975	ENSPREP00000005959	ENSPREP00000029641	Cell division cycle 42.	Uncharacterized protein.	0.528
CDC42	LOC103482188	ENSPREP00000005959	ENSPREP00000004852	Cell division cycle 42.	Rac family small GTPase 3b.	0.521
CDC42	MAPKAPK3	ENSPREP00000005959	ENSPREP00000017774	Cell division cycle 42.	MAPK activated protein kinase 3; Belongs to the protein kinase superfamily.	0.463