(61 nodes) RIG-I-like receptor signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pin1	Peptidyl-prolyl cis-trans isomerase. (156 aa)
	LOC103480680	Uncharacterized protein. (613 aa)
	tradd	Tnfrsf1a-associated via death domain. (271 aa)
	map3k7	Mitogen-activated protein kinase kinase kinase 7. (600 aa)
	ENSPREP00000002275	DED domain-containing protein. (147 aa)
	ENSPREP00000002335	Uncharacterized protein. (223 aa)
	LOC103478931	Uncharacterized protein; Belongs to the peptidase C14A family. (444 aa)
	LOC103478932	Caspase 20, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (389 aa)
	LOC108167062	Uncharacterized protein; Belongs to the peptidase C14A family. (224 aa)
	otud5	OTU deubiquitinase 5a. (551 aa)
	LOC103466877	Mitogen-activated protein kinase. (364 aa)
	LOC103464907	Mitogen-activated protein kinase. (363 aa)
	LOC103475941	C-X-C motif chemokine. (104 aa)
	ENSPREP00000004948	SCY domain-containing protein. (87 aa)
	traf6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (572 aa)
	LOC103471253	Mitogen-activated protein kinase. (420 aa)
	traf3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (590 aa)
	sting1	Transmembrane protein 173. (484 aa)
	LOC103459939	Caspase 10, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (507 aa)
	cyld	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family. (924 aa)
	mavs	CARD_2 domain-containing protein. (552 aa)
	IL12B	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (323 aa)
	LOC103474837	Uncharacterized protein. (612 aa)
	ifih1	Interferon induced with helicase C domain 1. (969 aa)
	tank	TRAF family member-associated NFKB activator. (338 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	atg12	Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (138 aa)
	ENSPREP00000013477	Si:ch211-1n9.6. (58 aa)
	LOC103467000	Mitogen-activated protein kinase. (366 aa)
	LOC103469546	Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (128 aa)
	LOC103470011	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (295 aa)
	dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58. (681 aa)
	LOC108167267	Uncharacterized protein. (184 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	sike1	Suppressor of IKBKE 1. (220 aa)
	azi2	5-azacytidine induced 2. (402 aa)
	LOC103474866	Uncharacterized protein; Belongs to the DEAD box helicase family. (733 aa)
	LOC103469462	Bloodthirsty-related gene family, member 30. (621 aa)
	ENSPREP00000018384	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (290 aa)
	tbkbp1	TBK1 binding protein 1. (699 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (772 aa)
	LOC103469572	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	nlrx1	NLR family member X1. (937 aa)
	LOC103473816	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	tkfc	Triokinase/FMN cyclase. (583 aa)
	LOC103469624	Uncharacterized protein. (117 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	tbk1	TANK-binding kinase 1. (703 aa)
	irf7	Interferon regulatory factor 7. (472 aa)
	atg5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	il12b	Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (382 aa)
	LOC103472730	Uncharacterized protein. (514 aa)
	LOC103466181	Uncharacterized protein. (383 aa)
	LOC103466203	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (359 aa)
	mapk8	Mitogen-activated protein kinase. (426 aa)
	LOC103476976	Component of inhibitor of nuclear factor kappa B kinase complex. (689 aa)
	LOC103480184	V-rel avian reticuloendotheliosis viral oncogene homolog A. (627 aa)
	LOC103481249	Interferon regulatory factor 3. (465 aa)
	LOC103465561	Cylindromatosis (turban tumor syndrome), b. (715 aa)
	LOC103467285	Mitogen-activated protein kinase. (347 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHUK	ENSPREP00000002275	ENSPREP00000020163	ENSPREP00000002275	Component of inhibitor of nuclear factor kappa B kinase complex.	DED domain-containing protein.	0.511
CHUK	ENSPREP00000018384	ENSPREP00000020163	ENSPREP00000018384	Component of inhibitor of nuclear factor kappa B kinase complex.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.963
CHUK	LOC103457805	ENSPREP00000020163	ENSPREP00000027480	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC103465561	ENSPREP00000020163	ENSPREP00000032899	Component of inhibitor of nuclear factor kappa B kinase complex.	Cylindromatosis (turban tumor syndrome), b.	0.556
CHUK	LOC103469572	ENSPREP00000020163	ENSPREP00000021110	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.593
CHUK	LOC103473816	ENSPREP00000020163	ENSPREP00000022240	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.593
CHUK	LOC103476976	ENSPREP00000020163	ENSPREP00000032137	Component of inhibitor of nuclear factor kappa B kinase complex.	Component of inhibitor of nuclear factor kappa B kinase complex.	0.943
CHUK	LOC103480184	ENSPREP00000020163	ENSPREP00000032422	Component of inhibitor of nuclear factor kappa B kinase complex.	V-rel avian reticuloendotheliosis viral oncogene homolog A.	0.674
CHUK	LOC103481249	ENSPREP00000020163	ENSPREP00000032515	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 3.	0.508
CHUK	azi2	ENSPREP00000020163	ENSPREP00000017750	Component of inhibitor of nuclear factor kappa B kinase complex.	5-azacytidine induced 2.	0.583
CHUK	cyld	ENSPREP00000020163	ENSPREP00000010113	Component of inhibitor of nuclear factor kappa B kinase complex.	Cylindromatosis (turban tumor syndrome), a; Belongs to the peptidase C19 family.	0.556
CHUK	ikbkb	ENSPREP00000020163	ENSPREP00000016563	Component of inhibitor of nuclear factor kappa B kinase complex.	Inhibitor of nuclear factor kappa B kinase subunit beta.	0.950
CHUK	irf7	ENSPREP00000020163	ENSPREP00000028492	Component of inhibitor of nuclear factor kappa B kinase complex.	Interferon regulatory factor 7.	0.953
CHUK	map3k7	ENSPREP00000020163	ENSPREP00000002180	Component of inhibitor of nuclear factor kappa B kinase complex.	Mitogen-activated protein kinase kinase kinase 7.	0.961
CHUK	nfkbia	ENSPREP00000020163	ENSPREP00000012072	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b.	0.958
CHUK	nlrx1	ENSPREP00000020163	ENSPREP00000021597	Component of inhibitor of nuclear factor kappa B kinase complex.	NLR family member X1.	0.536
CHUK	sting1	ENSPREP00000020163	ENSPREP00000006284	Component of inhibitor of nuclear factor kappa B kinase complex.	Transmembrane protein 173.	0.814
CHUK	tank	ENSPREP00000020163	ENSPREP00000011950	Component of inhibitor of nuclear factor kappa B kinase complex.	TRAF family member-associated NFKB activator.	0.530
CHUK	tbkbp1	ENSPREP00000020163	ENSPREP00000018982	Component of inhibitor of nuclear factor kappa B kinase complex.	TBK1 binding protein 1.	0.604
CHUK	tradd	ENSPREP00000020163	ENSPREP00000001843	Component of inhibitor of nuclear factor kappa B kinase complex.	Tnfrsf1a-associated via death domain.	0.655