(141 nodes) Insulin signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRIP10	Thyroid hormone receptor interactor 10b. (507 aa)
	prkaca	Uncharacterized protein; Belongs to the protein kinase superfamily. (327 aa)
	tsc2	TSC complex subunit 2. (1898 aa)
	LOC103473984	CBM21 domain-containing protein. (333 aa)
	gsk3b	Glycogen synthase kinase 3 beta, genome duplicate a; Belongs to the protein kinase superfamily. (421 aa)
	LOC103473427	Rap guanine nucleotide exchange factor (GEF) 1b. (1200 aa)
	ENSPREP00000001430	Protein phosphatase 1, regulatory subunit 3Db. (264 aa)
	LOC103467754	Tyrosine-protein phosphatase non-receptor type. (432 aa)
	acaca	Acetyl-CoA carboxylase alpha. (2251 aa)
	SH2B2	SH2B adaptor protein 2. (689 aa)
	LOC103475907	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC103460523	Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family. (252 aa)
	pik3r3	Uncharacterized protein. (474 aa)
	rptor	Regulatory associated protein of MTOR, complex 1. (1350 aa)
	LOC103472417	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (470 aa)
	phkb	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1088 aa)
	LOC103471253	Mitogen-activated protein kinase. (420 aa)
	socs3	Suppressor of cytokine signaling 3. (208 aa)
	fasn	Coiled-coil domain containing 57. (2516 aa)
	LOC103480109	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
	LOC103468785	Protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate a; Belongs to the protein kinase superfamily. (351 aa)
	LOC103478998	Uncharacterized protein. (512 aa)
	rps6	40S ribosomal protein S6; Belongs to the eukaryotic ribosomal protein eS6 family. (247 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1207 aa)
	LOC103461355	Suppressor of cytokine signaling 3a. (165 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1138 aa)
	LOC103480255	Insulin receptor substrate 4a. (1360 aa)
	Ppp1r3b	Protein phosphatase 1 regulatory subunit. (243 aa)
	LOC103468878	Thyroid hormone receptor interactor 10a. (558 aa)
	LOC103479066	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	prkcz	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (608 aa)
	crkl	V-crk avian sarcoma virus CT10 oncogene homolog-like. (310 aa)
	ppp1cb	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	flot2	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (434 aa)
	LOC103476518	Insulin receptor substrate 2a. (1060 aa)
	prkar1b	Protein kinase, cAMP-dependent, regulatory, type I, beta. (511 aa)
	inpp5a	Inositol polyphosphate-5-phosphatase L. (394 aa)
	ENSPREP00000011280	Zgc:77112. (291 aa)
	exoc7	Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (716 aa)
	LOC103472976	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (350 aa)
	mknk2	MAPK interacting serine/threonine kinase 2b; Belongs to the protein kinase superfamily. (475 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	map2k2	Mitogen-activated protein kinase kinase 2a; Belongs to the protein kinase superfamily. (399 aa)
	LOC103473021	Lipase, hormone-sensitive a. (682 aa)
	LOC103476099	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (509 aa)
	ENSPREP00000013735	Phosphotransferase. (233 aa)
	crk	CRK proto-oncogene, adaptor protein. (315 aa)
	LOC103479663	Protein kinase, cAMP-dependent, catalytic, beta b; Belongs to the protein kinase superfamily. (351 aa)
	pik3r2	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (701 aa)
	g6pc3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (339 aa)
	Ppp1r3a	CBM21 domain-containing protein. (236 aa)
	gck	Phosphotransferase. (433 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)
	map2k1	Mitogen-activated protein kinase kinase 1; Belongs to the protein kinase superfamily. (394 aa)
	LOC103471822	Eukaryotic translation initiation factor 4ea; Belongs to the eukaryotic initiation factor 4E family. (215 aa)
	mknk1	MAPK interacting serine/threonine kinase 1; Belongs to the protein kinase superfamily. (425 aa)
	LOC103480412	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1198 aa)
	LOC103460160	Uncharacterized protein. (318 aa)
	LOC103468963	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (334 aa)
	calm2	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family. (149 aa)
	LOC103479739	Uncharacterized protein. (183 aa)
	rhoq	Ras homolog family member Q. (222 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (348 aa)
	LOC103481694	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (351 aa)
	shc2	SHC (Src homology 2 domain containing) transforming protein 2. (715 aa)
	LOC103463319	Uncharacterized protein. (406 aa)
	Elk1	ETS domain-containing protein. (135 aa)
	ENSPREP00000017971	CBM21 domain-containing protein. (266 aa)
	gys2	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (704 aa)
	LOC103480483	Si:ch73-335l21.1. (1307 aa)
	prkar2a	Protein kinase, cAMP-dependent, regulatory, type II, alpha A. (388 aa)
	rhebl1	Ras homolog, mTORC1 binding like 1. (184 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (334 aa)
	braf	B-Raf proto-oncogene, serine/threonine kinase. (781 aa)
	flot1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (503 aa)
	mapk1	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (364 aa)
	LOC103469088	Zgc:55558. (191 aa)
	gys1	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan. (709 aa)
	LOC103469576	A-Raf proto-oncogene, serine/threonine kinase. (605 aa)
	LOC103475003	Forkhead box O1 a. (664 aa)
	prkacb	Uncharacterized protein; Belongs to the protein kinase superfamily. (380 aa)
	lipe	Lipase, hormone-sensitive b. (825 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	LOC103476312	Uncharacterized protein. (857 aa)
	LOC103469111	Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (367 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (267 aa)
	LOC103462844	Hexokinase domain containing 1. (907 aa)
	LOC103462845	Phosphotransferase. (264 aa)
	ppp1cc	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (342 aa)
	LOC103470739	Fructose-1,6-bisphosphatase 1a; Belongs to the FBPase class 1 family. (338 aa)
	ENSPREP00000023825	SH2 domain-containing protein. (93 aa)
	LOC103470743	Fructose-1,6-bisphosphatase 2; Belongs to the FBPase class 1 family. (333 aa)
	Eif4e2	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family. (222 aa)
	LOC103482256	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (331 aa)
	LOC103474395	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (498 aa)
	LOC103467246	Protein phosphatase 1, regulatory subunit 3Da. (342 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (600 aa)
	SHC3	SHC adaptor protein 3. (664 aa)
	pygl	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (676 aa)
	phkg2	Phosphorylase kinase, gamma 2 (testis); Belongs to the protein kinase superfamily. (383 aa)
	ENSPREP00000026193	Phosphotransferase. (242 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (538 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (645 aa)
	kras	V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog. (189 aa)
	ENSPREP00000027386	Suppressor of cytokine signaling 4. (395 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	LOC103476881	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family. (217 aa)
	LOC103475454	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. (842 aa)
	LOC103459817	Suppressor of cytokine signaling 2. (196 aa)
	hras	HRas proto-oncogene, GTPase a. (189 aa)
	LOC103462037	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family. (1242 aa)
	ENSPREP00000028643	Uncharacterized protein. (199 aa)
	inppl1	Inositol polyphosphate phosphatase-like 1a. (1248 aa)
	prkar1a	Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1) b. (380 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
	LOC103469702	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
	bad	BCL2 associated agonist of cell death b. (166 aa)
	LOC103473350	Fructose-bisphosphatase 1; Belongs to the FBPase class 1 family. (337 aa)
	LOC103475233	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	HK1	Hexokinase 1. (923 aa)
	mapk8	Mitogen-activated protein kinase. (426 aa)
	EIF4EBP1	Eukaryotic translation initiation factor 4E binding protein 1. (123 aa)
	tsc1	TSC complex subunit 1b. (1243 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (637 aa)
	PPP1CB	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
	phkg1	Phosphorylase kinase, gamma 1a (muscle); Belongs to the protein kinase superfamily. (394 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	Pik3ca	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (306 aa)
	foxo1	Fork-head domain-containing protein. (638 aa)
	irs2	Insulin receptor substrate 2b. (1115 aa)
	pde3b	Phosphodiesterase. (1096 aa)
	LOC103481373	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (325 aa)
	ppp1r3c	Protein phosphatase 1 regulatory subunit. (340 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF4EBP1	Eif4e2	ENSPREP00000032026	ENSPREP00000023893	Eukaryotic translation initiation factor 4E binding protein 1.	Eukaryotic translation initiation factor 4E family member 2; Belongs to the eukaryotic initiation factor 4E family.	0.937
EIF4EBP1	LOC103460523	ENSPREP00000032026	ENSPREP00000003386	Eukaryotic translation initiation factor 4E binding protein 1.	Eukaryotic translation initiation factor 4eb; Belongs to the eukaryotic initiation factor 4E family.	0.990
EIF4EBP1	LOC103471822	ENSPREP00000032026	ENSPREP00000015467	Eukaryotic translation initiation factor 4E binding protein 1.	Eukaryotic translation initiation factor 4ea; Belongs to the eukaryotic initiation factor 4E family.	0.990
EIF4EBP1	LOC103472417	ENSPREP00000032026	ENSPREP00000004747	Eukaryotic translation initiation factor 4E binding protein 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.473
EIF4EBP1	LOC103474395	ENSPREP00000032026	ENSPREP00000024636	Eukaryotic translation initiation factor 4E binding protein 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.473
EIF4EBP1	LOC103476099	ENSPREP00000032026	ENSPREP00000013562	Eukaryotic translation initiation factor 4E binding protein 1.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.473
EIF4EBP1	LOC103476881	ENSPREP00000032026	ENSPREP00000027909	Eukaryotic translation initiation factor 4E binding protein 1.	Eukaryotic translation initiation factor 4E family member 1c; Belongs to the eukaryotic initiation factor 4E family.	0.984
EIF4EBP1	Mtor	ENSPREP00000032026	ENSPREP00000016474	Eukaryotic translation initiation factor 4E binding protein 1.	Serine/threonine-protein kinase TOR.	0.955
EIF4EBP1	rptor	ENSPREP00000032026	ENSPREP00000004520	Eukaryotic translation initiation factor 4E binding protein 1.	Regulatory associated protein of MTOR, complex 1.	0.727
EIF4EBP1	tsc2	ENSPREP00000032026	ENSPREP00000000549	Eukaryotic translation initiation factor 4E binding protein 1.	TSC complex subunit 2.	0.404
ENSPREP00000001430	LOC103462037	ENSPREP00000001430	ENSPREP00000028584	Protein phosphatase 1, regulatory subunit 3Db.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.657
ENSPREP00000001430	LOC103480412	ENSPREP00000001430	ENSPREP00000015651	Protein phosphatase 1, regulatory subunit 3Db.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.657
ENSPREP00000001430	calm2	ENSPREP00000001430	ENSPREP00000015904	Protein phosphatase 1, regulatory subunit 3Db.	Calmodulin 2a (phosphorylase kinase, delta); Belongs to the calmodulin family.	0.650
ENSPREP00000001430	gys1	ENSPREP00000001430	ENSPREP00000020428	Protein phosphatase 1, regulatory subunit 3Db.	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.	0.888
ENSPREP00000001430	gys2	ENSPREP00000001430	ENSPREP00000018026	Protein phosphatase 1, regulatory subunit 3Db.	Glycogen [starch] synthase; Transfers the glycosyl residue from UDP-Glc to the non- reducing end of alpha-1,4-glucan.	0.888
ENSPREP00000001430	phkb	ENSPREP00000001430	ENSPREP00000004907	Protein phosphatase 1, regulatory subunit 3Db.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.673
ENSPREP00000001430	phkg1	ENSPREP00000001430	ENSPREP00000032644	Protein phosphatase 1, regulatory subunit 3Db.	Phosphorylase kinase, gamma 1a (muscle); Belongs to the protein kinase superfamily.	0.667
ENSPREP00000001430	phkg2	ENSPREP00000001430	ENSPREP00000026190	Protein phosphatase 1, regulatory subunit 3Db.	Phosphorylase kinase, gamma 2 (testis); Belongs to the protein kinase superfamily.	0.667
ENSPREP00000011280	LOC103462037	ENSPREP00000011280	ENSPREP00000028584	Zgc:77112.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.658
ENSPREP00000011280	LOC103480412	ENSPREP00000011280	ENSPREP00000015651	Zgc:77112.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.666