(79 nodes) Adipocytokine signaling pathway network (Poecilia reticulata)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	NPY	Neuropeptide Y. (92 aa)
	LOC103457563	Uncharacterized protein. (236 aa)
	tradd	Tnfrsf1a-associated via death domain. (271 aa)
	ENSPREP00000002541	Agouti domain-containing protein. (163 aa)
	ENSPREP00000002706	Neuropeptide Y. (109 aa)
	ENSPREP00000002941	Uncharacterized protein. (156 aa)
	ACSL1	Acyl-CoA synthetase long chain family member 1. (691 aa)
	LOC103475331	AMP-binding domain-containing protein. (685 aa)
	LOC103471253	Mitogen-activated protein kinase. (420 aa)
	socs3	Suppressor of cytokine signaling 3. (208 aa)
	LOC103459286	Adiponectin receptor 2. (343 aa)
	acsl1	Acyl-CoA synthetase long chain family member 1a. (698 aa)
	LOC103464471	Tumor necrosis factor receptor superfamily, member 1B. (441 aa)
	LOC103461355	Suppressor of cytokine signaling 3a. (165 aa)
	LOC103474789	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	LOC103480255	Insulin receptor substrate 4a. (1360 aa)
	RXRB	Retinoid X receptor beta. (417 aa)
	LOC103470507	Acyl-CoA synthetase long chain family member 2. (699 aa)
	LOC103479079	Agouti signaling protein, nonagouti homolog (mouse) 2b. (115 aa)
	LOC103476518	Insulin receptor substrate 2a. (1060 aa)
	LOC103473604	Si:ch73-62l21.1. (572 aa)
	LOC103469930	AMP-binding domain-containing protein. (699 aa)
	nfkbia	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha b. (315 aa)
	LOC103469946	Tyrosine-protein kinase. (1122 aa)
	nfkbie	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon. (343 aa)
	LOC103476681	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	acsbg2	Acyl-CoA synthetase bubblegum family member 2. (798 aa)
	jak2	Tyrosine-protein kinase. (1190 aa)
	LOC103458231	MFS domain-containing protein; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (483 aa)
	LOC103466997	Solute carrier family 2 member 1a; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (512 aa)
	ppara	Peroxisome proliferator-activated receptor alpha a. (472 aa)
	stat3	Signal transducer and activator of transcription. (825 aa)
	g6pc3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (339 aa)
	pck1	Phosphoenolpyruvate carboxykinase 1 (soluble). (624 aa)
	acsl3	Uncharacterized protein. (719 aa)
	LOC103460160	Uncharacterized protein. (318 aa)
	lepr	Uncharacterized protein. (1121 aa)
	LOC103463575	Uncharacterized protein. (438 aa)
	Mtor	Serine/threonine-protein kinase TOR. (1001 aa)
	ikbkb	Inhibitor of nuclear factor kappa B kinase subunit beta. (743 aa)
	ENSPREP00000016743	Uncharacterized protein. (269 aa)
	LOC103467098	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	g6pc	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (348 aa)
	LOC103481694	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (351 aa)
	PPARA	Peroxisome proliferator-activated receptor alpha b. (469 aa)
	LOC103468298	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family. (788 aa)
	LOC103480483	Si:ch73-335l21.1. (1307 aa)
	prkag1	Protein kinase, AMP-activated, gamma 1 non-catalytic subunit. (334 aa)
	LOC103464733	Solute carrier family 2 member 1b; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (493 aa)
	SLC2A4	Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (503 aa)
	CHUK	Component of inhibitor of nuclear factor kappa B kinase complex. (772 aa)
	adipor1	Adiponectin receptor 1a. (380 aa)
	LOC103469572	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
	LOC103473816	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (532 aa)
	cpt1b	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family. (787 aa)
	PRKAB2	Protein kinase AMP-activated non-catalytic subunit beta 2. (267 aa)
	LOC103482256	Protein kinase, AMP-activated, gamma 3b non-catalytic subunit. (331 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	LOC103479395	Acyl-CoA synthetase long chain family member 3b. (709 aa)
	stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
	prkcq	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (719 aa)
	LOC103457805	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a. (301 aa)
	mapk10	Mitogen-activated protein kinase. (426 aa)
	LOC103466156	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family. (772 aa)
	LOC103469702	Protein kinase, AMP-activated, beta 1 non-catalytic subunit, b. (265 aa)
	LOC103470977	Acyl-CoA synthetase long chain family member 4a. (567 aa)
	LOC103470003	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
	LOC103472811	Uncharacterized protein. (209 aa)
	prkaa2	Non-specific serine/threonine protein kinase. (557 aa)
	akt1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (473 aa)
	mapk8	Mitogen-activated protein kinase. (426 aa)
	prkaa1	Non-specific serine/threonine protein kinase. (637 aa)
	LOC103476976	Component of inhibitor of nuclear factor kappa B kinase complex. (689 aa)
	LOC103481241	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family. (783 aa)
	LOC103480184	V-rel avian reticuloendotheliosis viral oncogene homolog A. (627 aa)
	Rxra	Retinoid X receptor, alpha a. (410 aa)
	LOC103459298	CD36 molecule (thrombospondin receptor); Belongs to the CD36 family. (409 aa)
	acacb	Acetyl-CoA carboxylase beta. (2054 aa)
	irs2	Insulin receptor substrate 2b. (1115 aa)

Your Current Organism:

Poecilia reticulata

NCBI taxonomy Id: 8081
Other names: Acanthophacelus reticulata, P. reticulata, Poecilia (Acanthophacelus) reticulata, Poecilia latipinna reticulata, guppy

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACSL1	ENSPREP00000016743	ENSPREP00000003059	ENSPREP00000016743	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.624
ACSL1	LOC103466156	ENSPREP00000003059	ENSPREP00000029364	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1Ab (liver); Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	LOC103468298	ENSPREP00000003059	ENSPREP00000017986	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1Cb; Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	LOC103469930	ENSPREP00000003059	ENSPREP00000011737	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.675
ACSL1	LOC103470003	ENSPREP00000003059	ENSPREP00000030956	Acyl-CoA synthetase long chain family member 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.429
ACSL1	LOC103470507	ENSPREP00000003059	ENSPREP00000009617	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 2.	0.609
ACSL1	LOC103470977	ENSPREP00000003059	ENSPREP00000030920	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 4a.	0.765
ACSL1	LOC103474789	ENSPREP00000003059	ENSPREP00000008269	Acyl-CoA synthetase long chain family member 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.429
ACSL1	LOC103475331	ENSPREP00000003059	ENSPREP00000005590	Acyl-CoA synthetase long chain family member 1.	AMP-binding domain-containing protein.	0.607
ACSL1	LOC103476681	ENSPREP00000003059	ENSPREP00000012589	Acyl-CoA synthetase long chain family member 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.429
ACSL1	LOC103479395	ENSPREP00000003059	ENSPREP00000025116	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 3b.	0.763
ACSL1	LOC103481241	ENSPREP00000003059	ENSPREP00000032406	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1C; Belongs to the carnitine/choline acetyltransferase family.	0.687
ACSL1	acsbg2	ENSPREP00000003059	ENSPREP00000012918	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase bubblegum family member 2.	0.686
ACSL1	acsl1	ENSPREP00000003059	ENSPREP00000007641	Acyl-CoA synthetase long chain family member 1.	Acyl-CoA synthetase long chain family member 1a.	0.605
ACSL1	acsl3	ENSPREP00000003059	ENSPREP00000015628	Acyl-CoA synthetase long chain family member 1.	Uncharacterized protein.	0.763
ACSL1	akt1	ENSPREP00000003059	ENSPREP00000031683	Acyl-CoA synthetase long chain family member 1.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.429
ACSL1	cpt1b	ENSPREP00000003059	ENSPREP00000022416	Acyl-CoA synthetase long chain family member 1.	Carnitine palmitoyltransferase 1B (muscle); Belongs to the carnitine/choline acetyltransferase family.	0.693
CHUK	LOC103457805	ENSPREP00000020163	ENSPREP00000027480	Component of inhibitor of nuclear factor kappa B kinase complex.	Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha a.	0.958
CHUK	LOC103469572	ENSPREP00000020163	ENSPREP00000021110	Component of inhibitor of nuclear factor kappa B kinase complex.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.593
CHUK	LOC103470003	ENSPREP00000020163	ENSPREP00000030956	Component of inhibitor of nuclear factor kappa B kinase complex.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.958