(57 nodes) PI3K events in ERBB2 signaling, and Phosphotyrosine residue binding network (Xiphophorus maculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	grap2	GRB2 related adaptor protein 2a. (288 aa)
	erbb3	Protein kinase domain-containing protein. (1413 aa)
	SHC4	SHC adaptor protein 4. (538 aa)
	M3ZJA3_XIPMA	Epidermal growth factor. (946 aa)
	LOC102236577	Uncharacterized protein. (408 aa)
	LOC102227154	Ras protein specific guanine nucleotide releasing factor 1. (1175 aa)
	grb2	Growth factor receptor-bound protein 2b. (217 aa)
	pgr	Progesterone receptor. (638 aa)
	LOC102218230	Zgc:158659; Belongs to the PI3/PI4-kinase family. (1070 aa)
	LOC102228937	Melanoma receptor tyrosine-protein kinase; Probable receptor with tyrosine-protein kinase activity. (1167 aa)
	M4A2Z4_XIPMA	Receptor protein-tyrosine kinase. (1155 aa)
	hbegf	Heparin-binding EGF-like growth factor. (236 aa)
	LOC102232343	Epithelial mitogen homolog (mouse). (164 aa)
	LOC102226637	EGF-like domain-containing protein. (153 aa)
	LOC102218636	PH domain-containing protein. (763 aa)
	ptpn6	Protein tyrosine phosphatase non-receptor type 6. (565 aa)
	LOC102223330	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (608 aa)
	LOC102227965	GRB2 related adaptor protein a. (216 aa)
	akt2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (482 aa)
	kdr	Kinase insert domain receptor (a type III receptor tyrosine kinase); Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1333 aa)
	LOC102216436	Phosphoinositide-3-kinase, regulatory subunit 2 (beta). (728 aa)
	pdgfra	Platelet-derived growth factor receptor, alpha polypeptide; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1457 aa)
	LOC102224880	Rac family small GTPase 3b. (192 aa)
	LOC102235425	Uncharacterized protein. (726 aa)
	gab2	GRB2-associated binding protein 2. (676 aa)
	tgfa	Transforming growth factor, alpha. (245 aa)
	LOC102224423	Si:ch73-335l21.1. (1276 aa)
	LOC102231767	Receptor protein-tyrosine kinase. (1376 aa)
	LOC102236062	Receptor protein-tyrosine kinase. (1209 aa)
	pik3r1	Phosphoinositide-3-kinase, regulatory subunit 1 (alpha). (727 aa)
	pdpk1	3-phosphoinositide dependent protein kinase 1b. (565 aa)
	ptpn23	Protein tyrosine phosphatase, non-receptor type 23, a. (1872 aa)
	LOC102226157	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1152 aa)
	LOC102234385	Fibroblast growth factor receptor substrate 3. (610 aa)
	LOC102218549	Neuregulin 2a. (731 aa)
	pik3cb	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family. (1079 aa)
	LOC102225118	Rac family small GTPase 2. (192 aa)
	pik3r3	Uncharacterized protein. (473 aa)
	SRC	Tyrosine-protein kinase. (550 aa)
	shc1	SHC (Src homology 2 domain containing) transforming protein 1. (456 aa)
	gab1	GRB2-associated binding protein 1. (765 aa)
	LOC102229675	Vav 3 guanine nucleotide exchange factor b. (862 aa)
	SHC3	SHC adaptor protein 3. (668 aa)
	erbb4	Receptor protein-tyrosine kinase. (1450 aa)
	LOC102236685	Neuregulin 2b. (714 aa)
	sos1	Son of sevenless homolog 1 (Drosophila). (1342 aa)
	pik3cd	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1041 aa)
	ptpn11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (596 aa)
	LOC102225708	Erb-b2 receptor tyrosine kinase 3b. (1365 aa)
	LOC102233710	Uncharacterized protein. (195 aa)
	LOC102233436	Uncharacterized protein. (466 aa)
	erbb2	Receptor protein-tyrosine kinase. (1286 aa)
	LOC102216631	SHC (Src homology 2 domain containing) transforming protein 2. (717 aa)
	btc	EGF-like domain-containing protein. (189 aa)
	vav2	Vav 2 guanine nucleotide exchange factor. (880 aa)
	LOC102223666	EGF-like domain-containing protein. (623 aa)
	sos2	Son of sevenless homolog 2 (Drosophila). (1323 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102216436	LOC102216631	ENSXMAP00000013925	ENSXMAP00000037501	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	SHC (Src homology 2 domain containing) transforming protein 2.	0.465
LOC102216436	LOC102218230	ENSXMAP00000013925	ENSXMAP00000008625	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Zgc:158659; Belongs to the PI3/PI4-kinase family.	0.666
LOC102216436	LOC102218636	ENSXMAP00000013925	ENSXMAP00000011000	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	PH domain-containing protein.	0.873
LOC102216436	LOC102223330	ENSXMAP00000013925	ENSXMAP00000012391	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.517
LOC102216436	LOC102224423	ENSXMAP00000013925	ENSXMAP00000015549	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Si:ch73-335l21.1.	0.960
LOC102216436	LOC102224880	ENSXMAP00000013925	ENSXMAP00000014761	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Rac family small GTPase 3b.	0.769
LOC102216436	LOC102225118	ENSXMAP00000013925	ENSXMAP00000023636	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Rac family small GTPase 2.	0.769
LOC102216436	LOC102225708	ENSXMAP00000013925	ENSXMAP00000032209	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Erb-b2 receptor tyrosine kinase 3b.	0.803
LOC102216436	LOC102226157	ENSXMAP00000013925	ENSXMAP00000020887	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.666
LOC102216436	LOC102227965	ENSXMAP00000013925	ENSXMAP00000012404	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	GRB2 related adaptor protein a.	0.555
LOC102216436	LOC102228937	ENSXMAP00000013925	ENSXMAP00000008832	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Melanoma receptor tyrosine-protein kinase; Probable receptor with tyrosine-protein kinase activity.	0.461
LOC102216436	LOC102229675	ENSXMAP00000013925	ENSXMAP00000026677	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Vav 3 guanine nucleotide exchange factor b.	0.774
LOC102216436	LOC102231767	ENSXMAP00000013925	ENSXMAP00000016128	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Receptor protein-tyrosine kinase.	0.803
LOC102216436	LOC102233710	ENSXMAP00000013925	ENSXMAP00000036292	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Uncharacterized protein.	0.555
LOC102216436	LOC102234385	ENSXMAP00000013925	ENSXMAP00000021909	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Fibroblast growth factor receptor substrate 3.	0.433
LOC102216436	LOC102236062	ENSXMAP00000013925	ENSXMAP00000016567	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Receptor protein-tyrosine kinase.	0.803
LOC102216436	LOC102236685	ENSXMAP00000013925	ENSXMAP00000029246	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Neuregulin 2b.	0.418
LOC102216436	M3ZJA3_XIPMA	ENSXMAP00000013925	ENSXMAP00000002295	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Epidermal growth factor.	0.518
LOC102216436	M4A2Z4_XIPMA	ENSXMAP00000013925	ENSXMAP00000008838	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	Receptor protein-tyrosine kinase.	0.461
LOC102216436	SHC3	ENSXMAP00000013925	ENSXMAP00000028163	Phosphoinositide-3-kinase, regulatory subunit 2 (beta).	SHC adaptor protein 3.	0.562