(96 nodes) Mixed, incl. Wnt signaling pathway, and Negative regulation of TCF-dependent signaling by WNT ligand antagonists network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102222378	Four and a half LIM domains 1b. (280 aa)
	LOC102217702	Vang-like protein. (525 aa)
	LOC102227689	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	prickle2	Prickle homolog 2b. (916 aa)
	LOC102237295	Uncharacterized protein. (255 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	LOC102225926	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	sfrp5	Secreted frizzled-related protein 5. (318 aa)
	VANGL1	Vang-like protein. (531 aa)
	lrp6	Low density lipoprotein receptor-related protein 6. (1610 aa)
	LOC102238354	Uncharacterized protein. (325 aa)
	wls	Wnt ligand secretion mediator. (546 aa)
	LOC102218175	Vang-like protein. (539 aa)
	LOC102229577	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC102226987	Notum pectinacetylesterase 2. (507 aa)
	DACT1	Dishevelled binding antagonist of beta catenin 1. (816 aa)
	VANGL2	VANGL planar cell polarity protein 2. (635 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC102218548	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	frzb	Frizzled related protein. (313 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
	LOC102229429	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LOC102223878	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (240 aa)
	LOC102228929	Sp5 transcription factor-like. (366 aa)
	LOC102228256	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	sfrp1	Secreted frizzled-related protein 1a. (306 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (678 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
	LOC111609197	Si:dkey-100n23.5. (213 aa)
	notum	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	LOC102217940	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	LOC102216940	Uncharacterized protein. (603 aa)
	Fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	PRICKLE1	Prickle homolog 1a. (839 aa)
	LOC102238068	DAN domain family, member 5. (255 aa)
	LOC102220171	Protein tyrosine phosphatase domain containing 1b. (656 aa)
	LOC102233666	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	sost	Sclerostin. (225 aa)
	prickle3	Prickle homolog 3. (787 aa)
	DUSP26	Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (200 aa)
	LOC102233479	Dishevelled segment polarity protein 3a. (686 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	LOC102226874	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
	Fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC102237243	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	M4B140_XIPMA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (462 aa)
	LOC106700021	Uncharacterized protein. (370 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC102234982	Dickkopf WNT signaling pathway inhibitor 1a. (279 aa)
	ENSXMAP00000023438	Uncharacterized protein. (144 aa)
	ENSXMAP00000023463	Uncharacterized protein. (737 aa)
	kremen1	Kringle containing transmembrane protein 1. (476 aa)
	LOC102235828	Uncharacterized protein. (218 aa)
	LOC102238407	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	ENSXMAP00000026472	DIX domain-containing protein. (55 aa)
	LOC102229158	Uncharacterized protein. (341 aa)
	celsr1	Cadherin EGF LAG seven-pass G-type receptor 1a; Belongs to the G-protein coupled receptor 2 family. (3065 aa)
	LOC102236316	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (399 aa)
	LOC102234901	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
	LOC102232337	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	dkk2	Dickkopf WNT signaling pathway inhibitor 2. (245 aa)
	LOC102237424	Prickle homolog 1b. (938 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (692 aa)
	ENSXMAP00000031276	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
	dvl1	Dishevelled segment polarity protein 1a. (720 aa)
	ENSXMAP00000032085	Dickkopf_N domain-containing protein. (269 aa)
	ENSXMAP00000032350	Uncharacterized protein. (743 aa)
	ryk	Receptor like tyrosine kinase. (629 aa)
	nkd2	NKD inhibitor of WNT signaling pathway 2a. (499 aa)
	ENSXMAP00000033646	Uncharacterized protein. (89 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ENSXMAP00000035407	FZ domain-containing protein. (199 aa)
	LOC102231014	FH2 domain-containing protein. (1155 aa)
	LOC102238120	Uncharacterized protein. (917 aa)
	LOC102236939	Uncharacterized protein. (1659 aa)
	ENSXMAP00000036904	Uncharacterized protein. (252 aa)
	lrp5	Low density lipoprotein receptor-related protein 5. (1649 aa)
	Tub	Tubby-like protein; Belongs to the TUB family. (464 aa)
	LOC102228510	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
	invs	Inversin. (993 aa)
	LOC111611118	Dickkopf_N domain-containing protein. (275 aa)
	nkd1	NKD inhibitor of WNT signaling pathway 1. (479 aa)
	fhl1	Four and a half LIM domains 1a. (298 aa)
	LOC102232482	Uncharacterized protein. (521 aa)
	wnt8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
	ENSXMAP00000041386	Uncharacterized protein. (482 aa)
	fhdc1	FH2 domain containing 1. (1145 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DACT1	ENSXMAP00000026472	ENSXMAP00000004931	ENSXMAP00000026472	Dishevelled binding antagonist of beta catenin 1.	DIX domain-containing protein.	0.737
DACT1	LOC102216940	ENSXMAP00000004931	ENSXMAP00000014200	Dishevelled binding antagonist of beta catenin 1.	Uncharacterized protein.	0.737
DACT1	LOC102217702	ENSXMAP00000004931	ENSXMAP00000001154	Dishevelled binding antagonist of beta catenin 1.	Vang-like protein.	0.410
DACT1	LOC102218175	ENSXMAP00000004931	ENSXMAP00000004232	Dishevelled binding antagonist of beta catenin 1.	Vang-like protein.	0.544
DACT1	LOC102233479	ENSXMAP00000004931	ENSXMAP00000019035	Dishevelled binding antagonist of beta catenin 1.	Dishevelled segment polarity protein 3a.	0.737
DACT1	VANGL1	ENSXMAP00000004931	ENSXMAP00000002799	Dishevelled binding antagonist of beta catenin 1.	Vang-like protein.	0.561
DACT1	VANGL2	ENSXMAP00000004931	ENSXMAP00000005603	Dishevelled binding antagonist of beta catenin 1.	VANGL planar cell polarity protein 2.	0.410
DACT1	dvl1	ENSXMAP00000004931	ENSXMAP00000032053	Dishevelled binding antagonist of beta catenin 1.	Dishevelled segment polarity protein 1a.	0.737
ENSXMAP00000023438	ENSXMAP00000023463	ENSXMAP00000023438	ENSXMAP00000023463	Uncharacterized protein.	Uncharacterized protein.	0.781
ENSXMAP00000023438	ENSXMAP00000036904	ENSXMAP00000023438	ENSXMAP00000036904	Uncharacterized protein.	Uncharacterized protein.	0.653
ENSXMAP00000023438	LOC102234982	ENSXMAP00000023438	ENSXMAP00000022374	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.525
ENSXMAP00000023438	kremen1	ENSXMAP00000023438	ENSXMAP00000024004	Uncharacterized protein.	Kringle containing transmembrane protein 1.	0.474
ENSXMAP00000023463	ENSXMAP00000023438	ENSXMAP00000023463	ENSXMAP00000023438	Uncharacterized protein.	Uncharacterized protein.	0.781
ENSXMAP00000023463	LOC102234982	ENSXMAP00000023463	ENSXMAP00000022374	Uncharacterized protein.	Dickkopf WNT signaling pathway inhibitor 1a.	0.525
ENSXMAP00000023463	kremen1	ENSXMAP00000023463	ENSXMAP00000024004	Uncharacterized protein.	Kringle containing transmembrane protein 1.	0.474
ENSXMAP00000026472	DACT1	ENSXMAP00000026472	ENSXMAP00000004931	DIX domain-containing protein.	Dishevelled binding antagonist of beta catenin 1.	0.737
ENSXMAP00000026472	ENSXMAP00000035407	ENSXMAP00000026472	ENSXMAP00000035407	DIX domain-containing protein.	FZ domain-containing protein.	0.536
ENSXMAP00000026472	Fzd10	ENSXMAP00000026472	ENSXMAP00000020135	DIX domain-containing protein.	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family.	0.547
ENSXMAP00000026472	Fzd8	ENSXMAP00000026472	ENSXMAP00000019636	DIX domain-containing protein.	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family.	0.480
ENSXMAP00000026472	Fzd9	ENSXMAP00000026472	ENSXMAP00000017131	DIX domain-containing protein.	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family.	0.547