(51 nodes) Wnt signaling pathway, and Pectinacetylesterase network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102227689	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	wnt6	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	ror1	Receptor tyrosine kinase-like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. (953 aa)
	LOC102225926	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (378 aa)
	sfrp5	Secreted frizzled-related protein 5. (318 aa)
	wls	Wnt ligand secretion mediator. (546 aa)
	LOC102229577	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
	wnt2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	LOC102226987	Notum pectinacetylesterase 2. (507 aa)
	wnt3a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	wnt9a	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (369 aa)
	LOC102218548	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (384 aa)
	WNT7A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (368 aa)
	LOC102229429	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (391 aa)
	wnt4	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
	LOC102223878	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	Wnt16	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (240 aa)
	LOC102228256	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	sfrp1	Secreted frizzled-related protein 1a. (306 aa)
	fzd3	Frizzled class receptor 3a; Belongs to the G-protein coupled receptor Fz/Smo family. (678 aa)
	wnt10b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (429 aa)
	notum	Notum, palmitoleoyl-protein carboxylesterase a. (500 aa)
	LOC102217940	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (450 aa)
	wnt11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (357 aa)
	Fzd9	Frizzled class receptor 9b; Belongs to the G-protein coupled receptor Fz/Smo family. (588 aa)
	LOC102238068	DAN domain family, member 5. (255 aa)
	LOC102233666	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (350 aa)
	Fzd8	Frizzled class receptor 8a; Belongs to the G-protein coupled receptor Fz/Smo family. (575 aa)
	LOC102226874	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (542 aa)
	Fzd10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (582 aa)
	LOC102237243	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (559 aa)
	M4B140_XIPMA	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (562 aa)
	porcn	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family. (462 aa)
	sfrp2	Secreted frizzled-related protein 2. (295 aa)
	LOC102238407	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (393 aa)
	LOC102229158	Uncharacterized protein. (341 aa)
	LOC102236316	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (399 aa)
	LOC102234901	Glypican 4; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (557 aa)
	LOC102232337	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (715 aa)
	fzd6	Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (692 aa)
	ENSXMAP00000031276	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (382 aa)
	ryk	Receptor like tyrosine kinase. (629 aa)
	wnt3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa)
	fzd4	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (531 aa)
	wnt1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	ENSXMAP00000035407	FZ domain-containing protein. (199 aa)
	LOC102238120	Uncharacterized protein. (917 aa)
	Tub	Tubby-like protein; Belongs to the TUB family. (464 aa)
	LOC102228510	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (345 aa)
	LOC102232482	Uncharacterized protein. (521 aa)
	wnt8b	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000031276	ENSXMAP00000035407	ENSXMAP00000031276	ENSXMAP00000035407	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	FZ domain-containing protein.	0.419
ENSXMAP00000031276	LOC102217940	ENSXMAP00000031276	ENSXMAP00000012887	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the membrane-bound acyltransferase family.	0.434
ENSXMAP00000031276	LOC102218548	ENSXMAP00000031276	ENSXMAP00000005991	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.420
ENSXMAP00000031276	LOC102223878	ENSXMAP00000031276	ENSXMAP00000009222	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.497
ENSXMAP00000031276	LOC102225926	ENSXMAP00000031276	ENSXMAP00000002620	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.431
ENSXMAP00000031276	LOC102227689	ENSXMAP00000031276	ENSXMAP00000001349	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.407
ENSXMAP00000031276	LOC102228256	ENSXMAP00000031276	ENSXMAP00000010484	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.488
ENSXMAP00000031276	LOC102228510	ENSXMAP00000031276	ENSXMAP00000037867	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.488
ENSXMAP00000031276	LOC102229429	ENSXMAP00000031276	ENSXMAP00000008141	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.420
ENSXMAP00000031276	LOC102229577	ENSXMAP00000031276	ENSXMAP00000004356	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
ENSXMAP00000031276	LOC102233666	ENSXMAP00000031276	ENSXMAP00000017649	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
ENSXMAP00000031276	LOC102236316	ENSXMAP00000031276	ENSXMAP00000027589	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.468
ENSXMAP00000031276	LOC102238120	ENSXMAP00000031276	ENSXMAP00000036695	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein.	0.419
ENSXMAP00000031276	LOC102238407	ENSXMAP00000031276	ENSXMAP00000026398	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.459
ENSXMAP00000031276	M4B140_XIPMA	ENSXMAP00000031276	ENSXMAP00000020437	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family.	0.402
ENSXMAP00000031276	WNT7A	ENSXMAP00000031276	ENSXMAP00000007541	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.411
ENSXMAP00000031276	Wnt16	ENSXMAP00000031276	ENSXMAP00000009549	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.519
ENSXMAP00000031276	fzd4	ENSXMAP00000031276	ENSXMAP00000034378	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family.	0.451
ENSXMAP00000031276	porcn	ENSXMAP00000031276	ENSXMAP00000020789	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Porcupine O-acyltransferase; Belongs to the membrane-bound acyltransferase family.	0.434
ENSXMAP00000031276	ryk	ENSXMAP00000031276	ENSXMAP00000033570	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	Receptor like tyrosine kinase.	0.536