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LOC102225228 LOC102225228 cacng3 cacng3 LOC102217191 LOC102217191 LOC102216915 LOC102216915 M3ZKN9_XIPMA M3ZKN9_XIPMA LOC102232640 LOC102232640 LOC102233017 LOC102233017 LOC102238041 LOC102238041 LOC102218567 LOC102218567 LOC102223158 LOC102223158 LOC102237143 LOC102237143 CACNG1 CACNG1 LOC102220117 LOC102220117 LOC102235612 LOC102235612 LOC102221379 LOC102221379 GRAMD2B GRAMD2B cacna1c cacna1c CACNA2D4 CACNA2D4 LOC102232366 LOC102232366 LOC102233709 LOC102233709 LOC102222615 LOC102222615 M4AH59_XIPMA M4AH59_XIPMA cacna1a cacna1a LOC102237040 LOC102237040 RASGRP1 RASGRP1 LOC102237380 LOC102237380 ptbp1 ptbp1 LOC102229832 LOC102229832 LOC102228089 LOC102228089 LOC102234457 LOC102234457 LOC102236811 LOC102236811 LOC102227354 LOC102227354 LOC102233459 LOC102233459 M4AUT7_XIPMA M4AUT7_XIPMA CACNA1D CACNA1D CACNA1E CACNA1E ENSXMAP00000021447 ENSXMAP00000021447 ENSXMAP00000022043 ENSXMAP00000022043 ENSXMAP00000022584 ENSXMAP00000022584 Cacna2d4 Cacna2d4 ENSXMAP00000023327 ENSXMAP00000023327 CACNG2 CACNG2 FAM155A FAM155A LOC102224234 LOC102224234 ENSXMAP00000025589 ENSXMAP00000025589 LOC102225715 LOC102225715 ENSXMAP00000026658 ENSXMAP00000026658 LOC102220377 LOC102220377 scn3b scn3b gramd1a gramd1a LOC102230764 LOC102230764 Unc80 Unc80 LOC102226345 LOC102226345 ENSXMAP00000029696 ENSXMAP00000029696 LOC102225925 LOC102225925 LOC102220955 LOC102220955 LOC102232371 LOC102232371 LOC102223620 LOC102223620 cacna1g cacna1g RASGRP2 RASGRP2 cacng4 cacng4 LOC102232874 LOC102232874 ENSXMAP00000032998 ENSXMAP00000032998 LOC102223705 LOC102223705 Cacna1e Cacna1e LOC102216859 LOC102216859 ENSXMAP00000034446 ENSXMAP00000034446 LOC102223518 LOC102223518 LOC102216851 LOC102216851 UNC79 UNC79 scn2b scn2b cacnb1 cacnb1 cacnb2 cacnb2 nalcn nalcn LOC102230152 LOC102230152 LOC102225112 LOC102225112 cacna1s cacna1s LOC102222365 LOC102222365 LOC102227037 LOC102227037 cacnb4 cacnb4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC102225228Si:ch211-156l18.7; Belongs to the intermediate filament family. (392 aa)
cacng3Calcium voltage-gated channel auxiliary subunit gamma 3. (317 aa)
LOC102217191Calcium channel, voltage-dependent, T type, alpha 1H subunit a. (2328 aa)
LOC102216915Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1728 aa)
M3ZKN9_XIPMAVGCC_alpha2 domain-containing protein. (218 aa)
LOC102232640Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2036 aa)
LOC102233017Calcium channel, voltage-dependent, beta 4b subunit. (510 aa)
LOC102238041Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1035 aa)
LOC102218567RAS guanyl releasing protein 4. (711 aa)
LOC102223158Uncharacterized protein. (1175 aa)
LOC102237143Two pore segment channel 3. (784 aa)
CACNG1Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (230 aa)
LOC102220117Voltage-dependent N-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1B gives rise to N-type calcium currents. (2144 aa)
LOC102235612Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1832 aa)
LOC102221379Calcium channel, voltage-dependent, beta 3b. (265 aa)
GRAMD2BGRAM domain containing 2B. (464 aa)
cacna1cVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1862 aa)
CACNA2D4Calcium voltage-gated channel auxiliary subunit alpha2delta 4. (412 aa)
LOC102232366Calcium channel, voltage-dependent, alpha 2/delta subunit 1a. (1079 aa)
LOC102233709Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
LOC102222615Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1793 aa)
M4AH59_XIPMACalcium channel, voltage dependent, alpha2/delta subunit 3. (450 aa)
cacna1aCalcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b. (2157 aa)
LOC102237040Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
RASGRP1RAS guanyl releasing protein 1. (670 aa)
LOC102237380Voltage-dependent calcium channel gamma-1 subunit; Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics. (228 aa)
ptbp1Polypyrimidine tract binding protein 1a. (576 aa)
LOC102229832Uncharacterized protein. (1473 aa)
LOC102228089Ras protein-specific guanine nucleotide-releasing factor 2b. (1266 aa)
LOC102234457Voltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2052 aa)
LOC102236811Uncharacterized protein. (1200 aa)
LOC102227354Calcium channel, voltage-dependent, alpha 2/delta subunit 2b. (1102 aa)
LOC102233459Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1749 aa)
M4AUT7_XIPMAVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1204 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2116 aa)
CACNA1ECalcium voltage-gated channel subunit alpha1 E. (722 aa)
ENSXMAP00000021447Ion_trans domain-containing protein. (293 aa)
ENSXMAP00000022043VWFA domain-containing protein. (439 aa)
ENSXMAP00000022584VGCC_alpha2 domain-containing protein. (109 aa)
Cacna2d4VGCC_alpha2 domain-containing protein. (187 aa)
ENSXMAP00000023327Ion_trans domain-containing protein. (158 aa)
CACNG2Voltage-dependent calcium channel gamma-2 subunit; Regulates the trafficking and gating properties of AMPA- selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (328 aa)
FAM155AFamily with sequence similarity 155 member A. (402 aa)
LOC102224234Sodium channel, voltage-gated, type I, beta a. (216 aa)
ENSXMAP00000025589Uncharacterized protein. (97 aa)
LOC102225715GRAM domain-containing protein. (428 aa)
ENSXMAP00000026658Uncharacterized protein. (104 aa)
LOC102220377IF rod domain-containing protein; Belongs to the intermediate filament family. (606 aa)
scn3bSodium channel, voltage-gated, type III, beta. (219 aa)
gramd1aGRAM domain containing 1A. (905 aa)
LOC102230764Calcium voltage-gated channel subunit alpha1 Ia. (2350 aa)
Unc80UNC80 domain-containing protein. (428 aa)
LOC102226345Family with sequence similarity 155 member A. (385 aa)
ENSXMAP00000029696Uncharacterized protein. (273 aa)
LOC102225925Ras protein-specific guanine nucleotide-releasing factor 2a. (1319 aa)
LOC102220955Voltage-dependent calcium channel gamma-7 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. Shows specificity only for GRIA1 and GRIA2. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (363 aa)
LOC102232371Myelin protein zero-like 2b. (221 aa)
LOC102223620Calcium channel, voltage-dependent, alpha 2/delta subunit 2a. (1108 aa)
cacna1gVoltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2456 aa)
RASGRP2RAS guanyl releasing protein 2. (598 aa)
cacng4Voltage-dependent calcium channel gamma-4 subunit; Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization; Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. (333 aa)
LOC102232874Calcium channel, voltage-dependent, beta 3a. (567 aa)
ENSXMAP00000032998Ca_chan_IQ domain-containing protein. (535 aa)
LOC102223705Calcium channel, voltage-dependent, gamma subunit 8b. (413 aa)
Cacna1eUncharacterized protein. (431 aa)
LOC102216859Calcium channel, voltage-dependent, R type, alpha 1E subunit b. (2385 aa)
ENSXMAP00000034446Uncharacterized protein. (412 aa)
LOC102223518Voltage-dependent T-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite ne [...] (2295 aa)
LOC102216851Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1968 aa)
UNC79Unc-79 homolog, NALCN channel complex subunit. (2499 aa)
scn2bSodium channel, voltage-gated, type II, beta. (219 aa)
cacnb1Calcium channel, voltage-dependent, beta 1 subunit. (670 aa)
cacnb2Calcium channel, voltage-dependent, beta 2a. (697 aa)
nalcnSodium leak channel, non-selective. (1803 aa)
LOC102230152Keratin 99; Belongs to the intermediate filament family. (414 aa)
LOC102225112Calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, a. (2383 aa)
cacna1sVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1798 aa)
LOC102222365Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1557 aa)
LOC102227037Calcium channel, voltage-dependent, gamma subunit 5b. (276 aa)
cacnb4Calcium channel, voltage-dependent, beta 4a subunit. (519 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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