(25 nodes) Voltage-gated sodium channel complex, and Domain in glucosyltransferases, myotubularins and other putative membrane-associated proteins network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC102225228	Si:ch211-156l18.7; Belongs to the intermediate filament family. (392 aa)
	LOC102216915	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1728 aa)
	LOC102237143	Two pore segment channel 3. (784 aa)
	LOC102235612	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1832 aa)
	GRAMD2B	GRAM domain containing 2B. (464 aa)
	LOC102233709	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1741 aa)
	LOC102222615	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1793 aa)
	LOC102237040	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2008 aa)
	LOC102233459	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1749 aa)
	ENSXMAP00000021447	Ion_trans domain-containing protein. (293 aa)
	ENSXMAP00000022584	VGCC_alpha2 domain-containing protein. (109 aa)
	FAM155A	Family with sequence similarity 155 member A. (402 aa)
	LOC102224234	Sodium channel, voltage-gated, type I, beta a. (216 aa)
	LOC102225715	GRAM domain-containing protein. (428 aa)
	LOC102220377	IF rod domain-containing protein; Belongs to the intermediate filament family. (606 aa)
	scn3b	Sodium channel, voltage-gated, type III, beta. (219 aa)
	gramd1a	GRAM domain containing 1A. (905 aa)
	Unc80	UNC80 domain-containing protein. (428 aa)
	LOC102226345	Family with sequence similarity 155 member A. (385 aa)
	LOC102232371	Myelin protein zero-like 2b. (221 aa)
	LOC102216851	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1968 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2499 aa)
	scn2b	Sodium channel, voltage-gated, type II, beta. (219 aa)
	nalcn	Sodium leak channel, non-selective. (1803 aa)
	LOC102222365	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (1557 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000021447	ENSXMAP00000022584	ENSXMAP00000021447	ENSXMAP00000022584	Ion_trans domain-containing protein.	VGCC_alpha2 domain-containing protein.	0.416
ENSXMAP00000021447	FAM155A	ENSXMAP00000021447	ENSXMAP00000025105	Ion_trans domain-containing protein.	Family with sequence similarity 155 member A.	0.447
ENSXMAP00000021447	LOC102224234	ENSXMAP00000021447	ENSXMAP00000025286	Ion_trans domain-containing protein.	Sodium channel, voltage-gated, type I, beta a.	0.639
ENSXMAP00000021447	LOC102232371	ENSXMAP00000021447	ENSXMAP00000031196	Ion_trans domain-containing protein.	Myelin protein zero-like 2b.	0.431
ENSXMAP00000021447	UNC79	ENSXMAP00000021447	ENSXMAP00000034573	Ion_trans domain-containing protein.	Unc-79 homolog, NALCN channel complex subunit.	0.990
ENSXMAP00000021447	scn2b	ENSXMAP00000021447	ENSXMAP00000034766	Ion_trans domain-containing protein.	Sodium channel, voltage-gated, type II, beta.	0.781
ENSXMAP00000021447	scn3b	ENSXMAP00000021447	ENSXMAP00000028233	Ion_trans domain-containing protein.	Sodium channel, voltage-gated, type III, beta.	0.479
ENSXMAP00000022584	ENSXMAP00000021447	ENSXMAP00000022584	ENSXMAP00000021447	VGCC_alpha2 domain-containing protein.	Ion_trans domain-containing protein.	0.416
ENSXMAP00000022584	LOC102216851	ENSXMAP00000022584	ENSXMAP00000034549	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102216915	ENSXMAP00000022584	ENSXMAP00000002247	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102222365	ENSXMAP00000022584	ENSXMAP00000041762	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102222615	ENSXMAP00000022584	ENSXMAP00000012924	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102233459	ENSXMAP00000022584	ENSXMAP00000017739	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102233709	ENSXMAP00000022584	ENSXMAP00000011674	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102235612	ENSXMAP00000022584	ENSXMAP00000007953	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102237040	ENSXMAP00000022584	ENSXMAP00000013913	VGCC_alpha2 domain-containing protein.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.416
ENSXMAP00000022584	LOC102237143	ENSXMAP00000022584	ENSXMAP00000006494	VGCC_alpha2 domain-containing protein.	Two pore segment channel 3.	0.416
ENSXMAP00000022584	nalcn	ENSXMAP00000022584	ENSXMAP00000038117	VGCC_alpha2 domain-containing protein.	Sodium leak channel, non-selective.	0.459
FAM155A	ENSXMAP00000021447	ENSXMAP00000025105	ENSXMAP00000021447	Family with sequence similarity 155 member A.	Ion_trans domain-containing protein.	0.447
FAM155A	LOC102216851	ENSXMAP00000025105	ENSXMAP00000034549	Family with sequence similarity 155 member A.	Sodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.	0.447