(15 nodes) Isoprenoid biosynthetic process network (Xiphophorus maculatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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Your Input:
	mvd	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (403 aa)
	idi1	Isopentenyl-diphosphate delta isomerase 1. (285 aa)
	nus1	NUS1 dehydrodolichyl diphosphate synthase subunit. (288 aa)
	LOC102231993	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (515 aa)
	hmgcr	3-hydroxy-3-methylglutaryl coenzyme A reductase. (884 aa)
	ggps1	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family. (315 aa)
	mvk	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (396 aa)
	pdss1	Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family. (429 aa)
	dhdds	Alkyl transferase; Belongs to the UPP synthase family. (335 aa)
	fdps	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (358 aa)
	LOC102229336	3-hydroxy-3-methylglutaryl coenzyme A reductase. (859 aa)
	pmvk	Phosphomevalonate kinase. (202 aa)
	coq2	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (380 aa)
	rusc1	Uncharacterized protein. (1574 aa)
	pdss2	Prenyl (decaprenyl) diphosphate synthase, subunit 2. (510 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102229336	LOC102231993	ENSXMAP00000019034	ENSXMAP00000006117	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	0.999
LOC102229336	coq2	ENSXMAP00000019034	ENSXMAP00000034079	3-hydroxy-3-methylglutaryl coenzyme A reductase.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.566
LOC102229336	dhdds	ENSXMAP00000019034	ENSXMAP00000013314	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.439
LOC102229336	fdps	ENSXMAP00000019034	ENSXMAP00000016189	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.666
LOC102229336	ggps1	ENSXMAP00000019034	ENSXMAP00000006571	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.648
LOC102229336	hmgcr	ENSXMAP00000019034	ENSXMAP00000006510	3-hydroxy-3-methylglutaryl coenzyme A reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.901
LOC102229336	idi1	ENSXMAP00000019034	ENSXMAP00000004599	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Isopentenyl-diphosphate delta isomerase 1.	0.747
LOC102229336	mvd	ENSXMAP00000019034	ENSXMAP00000003017	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Diphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes.	0.647
LOC102229336	mvk	ENSXMAP00000019034	ENSXMAP00000008032	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Mevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily.	0.993
LOC102229336	nus1	ENSXMAP00000019034	ENSXMAP00000005305	3-hydroxy-3-methylglutaryl coenzyme A reductase.	NUS1 dehydrodolichyl diphosphate synthase subunit.	0.439
LOC102229336	pdss1	ENSXMAP00000019034	ENSXMAP00000008346	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Prenyl (decaprenyl) diphosphate synthase, subunit 1; Belongs to the FPP/GGPP synthase family.	0.467
LOC102229336	pdss2	ENSXMAP00000019034	ENSXMAP00000035868	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Prenyl (decaprenyl) diphosphate synthase, subunit 2.	0.467
LOC102229336	pmvk	ENSXMAP00000019034	ENSXMAP00000032283	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Phosphomevalonate kinase.	0.496
LOC102229336	rusc1	ENSXMAP00000019034	ENSXMAP00000034901	3-hydroxy-3-methylglutaryl coenzyme A reductase.	Uncharacterized protein.	0.435
LOC102231993	LOC102229336	ENSXMAP00000006117	ENSXMAP00000019034	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999
LOC102231993	coq2	ENSXMAP00000006117	ENSXMAP00000034079	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.487
LOC102231993	dhdds	ENSXMAP00000006117	ENSXMAP00000013314	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Alkyl transferase; Belongs to the UPP synthase family.	0.543
LOC102231993	fdps	ENSXMAP00000006117	ENSXMAP00000016189	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Uncharacterized protein; Belongs to the FPP/GGPP synthase family.	0.967
LOC102231993	ggps1	ENSXMAP00000006117	ENSXMAP00000006571	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	Geranylgeranyl diphosphate synthase 1; Belongs to the FPP/GGPP synthase family.	0.754
LOC102231993	hmgcr	ENSXMAP00000006117	ENSXMAP00000006510	3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.	3-hydroxy-3-methylglutaryl coenzyme A reductase.	0.999