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| | mcm2 | DNA helicase; Belongs to the MCM family. (886 aa) |
| | cdca7l | Cell division cycle associated 7b. (398 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | LOC102224037 | Checkpoint kinase 2. (442 aa) |
| | MCMDC2 | Minichromosome maintenance domain containing 2. (649 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (335 aa) |
| | gins2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa) |
| | timeless | Timeless circadian clock. (1260 aa) |
| | rad51c | RAD51 paralog C. (352 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa) |
| | exd2 | Exonuclease 3'-5' domain containing 2. (639 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa) |
| | mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa) |
| | cdc7 | Cell division cycle 7 homolog (S. cerevisiae). (606 aa) |
| | M3ZPS4_XIPMA | Uncharacterized protein. (185 aa) |
| | LOC102220076 | Zgc:110269. (347 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa) |
| | mcm5 | DNA helicase; Belongs to the MCM family. (695 aa) |
| | orc5 | Origin recognition complex, subunit 5. (442 aa) |
| | rtel1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1165 aa) |
| | cdca7 | Cell division cycle associated 7a. (402 aa) |
| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1188 aa) |
| | hells | Helicase, lymphoid specific. (854 aa) |
| | lig1 | DNA ligase. (595 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (860 aa) |
| | pold3 | Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa) |
| | ten1 | TEN1 subunit of CST complex. (132 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (133 aa) |
| | atrip | Uncharacterized protein. (766 aa) |
| | rbbp8 | Uncharacterized protein. (638 aa) |
| | dbf4 | DBF4 zinc finger. (593 aa) |
| | brca2 | BRCA2 DNA repair associated. (3052 aa) |
| | nbn | Nibrin. (831 aa) |
| | polk | Polymerase (DNA directed) kappa. (935 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (364 aa) |
| | chtf18 | AAA domain-containing protein. (922 aa) |
| | pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa) |
| | orc3 | Origin recognition complex, subunit 3. (722 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (893 aa) |
| | sass6 | SAS-6 centriolar assembly protein. (582 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (870 aa) |
| | rad23a | RAD23 homolog A, nucleotide excision repair protein a. (369 aa) |
| | M4A3H1_XIPMA | HORMA domain containing 1. (241 aa) |
| | atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2443 aa) |
| | prim2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (501 aa) |
| | rmi2 | RecQ mediated genome instability 2. (143 aa) |
| | LOC102228171 | Centrin, EF-hand protein, 2. (174 aa) |
| | rfc1 | Replication factor C subunit 1. (1195 aa) |
| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1102 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (389 aa) |
| | brca1 | Uncharacterized protein. (1370 aa) |
| | mcph1 | Microcephalin 1. (817 aa) |
| | RPA1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa) |
| | stn1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (359 aa) |
| | exo1 | Exonuclease 1. (777 aa) |
| | polh | Polymerase (DNA directed), eta. (720 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (390 aa) |
| | rev1 | REV1 DNA directed polymerase. (1363 aa) |
| | rad51d | RAD51 paralog D. (339 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (425 aa) |
| | dmc1 | DNA meiotic recombinase 1; Belongs to the RecA family. (274 aa) |
| | hus1 | Checkpoint protein; Belongs to the HUS1 family. (271 aa) |
| | msh5 | MutS homolog 5. (787 aa) |
| | rad54b | RAD54 homolog B. (858 aa) |
| | pold4 | Si:dkey-28b4.7. (108 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (394 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa) |
| | LOC102218031 | ATPase family AAA domain containing 5a. (1810 aa) |
| | msh2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (937 aa) |
| | rpa2 | Replication protein A2. (278 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa) |
| | pcna | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (826 aa) |
| | rmi1 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (680 aa) |
| | recql4 | RecQ helicase-like 4. (1385 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (350 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa) |
| | bivm | Basic, immunoglobulin-like variable motif containing. (502 aa) |
| | CLSPN | Claspin. (1202 aa) |
| | atm | ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa) |
| | wdr76 | WD repeat-containing protein 76; Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. Belongs to the WD repeat DDB2/WDR76 family. (546 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa) |
| | spo11 | SPO11 initiator of meiotic double stranded breaks. (387 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1252 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (816 aa) |
| | MPHOSPH9 | M-phase phosphoprotein 9. (1251 aa) |
| | ercc5 | Excision repair cross-complementation group 5. (1097 aa) |
| | xpc | Xeroderma pigmentosum, complementation group C. (934 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (210 aa) |
| | M4AYA4_XIPMA | ANK_REP_REGION domain-containing protein. (378 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (189 aa) |
| | tdrd3 | Tudor domain containing 3. (796 aa) |
| | ctc1 | Uncharacterized protein. (794 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1509 aa) |
| | xpa | Xeroderma pigmentosum, complementation group A. (276 aa) |
| | pola1 | DNA polymerase. (1488 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa) |
| | poli | Polymerase (DNA directed) iota. (708 aa) |
| | ENSXMAP00000024871 | MCM domain-containing protein; Belongs to the MCM family. (351 aa) |
| | ENSXMAP00000025311 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (351 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (3006 aa) |
| | ENSXMAP00000025712 | BRCT domain-containing protein. (149 aa) |
| | blm | BLM RecQ like helicase. (1398 aa) |
| | mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (754 aa) |
| | ankrd11 | Ankyrin repeat domain 11. (2826 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (357 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | rhno1 | Si:ch73-352p4.5. (297 aa) |
| | psmc3ip | PSMC3 interacting protein. (220 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (616 aa) |
| | rad1 | RAD1 homolog (S. pombe). (289 aa) |
| | xrcc2 | X-ray repair cross complementing 2. (311 aa) |
| | rpa3 | Replication protein A3. (122 aa) |
| | msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (912 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1151 aa) |
| | Mcmbp | Uncharacterized protein. (112 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1346 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa) |
| | ENSXMAP00000034387 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (228 aa) |
| | dna2 | Uncharacterized protein. (1324 aa) |
| | Mcm9 | Uncharacterized protein. (158 aa) |
| | ENSXMAP00000034984 | MutS_I domain-containing protein. (206 aa) |
| | LOC102230232 | RPA_C domain-containing protein. (247 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa) |
| | orc2 | Origin recognition complex, subunit 2. (594 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (836 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (445 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (761 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (890 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1112 aa) |
| | mnd1 | Meiotic nuclear division protein 1 homolog; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. Belongs to the MND1 family. (199 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1312 aa) |
| | bard1 | BRCA1 associated RING domain 1. (800 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (868 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | LOC111609834 | DBF4-type domain-containing protein. (692 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1376 aa) |
