STRINGSTRING
rad51 rad51 LOC102224037 LOC102224037 rad51c rad51c exd2 exd2 top3a top3a mre11 mre11 top3b top3b rtel1 rtel1 brip1 brip1 atrip atrip rbbp8 rbbp8 brca2 brca2 nbn nbn xrcc3 xrcc3 atr atr rmi2 rmi2 brca1 brca1 mcph1 mcph1 RPA1 RPA1 exo1 exo1 rad51d rad51d meiob meiob rpa2 rpa2 rmi1 rmi1 recql4 recql4 atm atm tp53bp1 tp53bp1 tdrd3 tdrd3 topbp1 topbp1 ENSXMAP00000025712 ENSXMAP00000025712 blm blm ankrd11 ankrd11 xrcc2 xrcc2 rpa3 rpa3 palb2 palb2 dna2 dna2 LOC102230232 LOC102230232 rpa1 rpa1 rad52 rad52 rad50 rad50 bard1 bard1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rad51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
LOC102224037Checkpoint kinase 2. (442 aa)
rad51cRAD51 paralog C. (352 aa)
exd2Exonuclease 3'-5' domain containing 2. (639 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1023 aa)
mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
top3bDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (858 aa)
rtel1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1165 aa)
brip1BRCA1 interacting protein C-terminal helicase 1. (1188 aa)
atripUncharacterized protein. (766 aa)
rbbp8Uncharacterized protein. (638 aa)
brca2BRCA2 DNA repair associated. (3052 aa)
nbnNibrin. (831 aa)
xrcc3DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (364 aa)
atrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2443 aa)
rmi2RecQ mediated genome instability 2. (143 aa)
brca1Uncharacterized protein. (1370 aa)
mcph1Microcephalin 1. (817 aa)
RPA1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (700 aa)
exo1Exonuclease 1. (777 aa)
rad51dRAD51 paralog D. (339 aa)
meiobMethionine sulfoxide reductase B1b. (425 aa)
rpa2Replication protein A2. (278 aa)
rmi1RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (680 aa)
recql4RecQ helicase-like 4. (1385 aa)
atmATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1252 aa)
tdrd3Tudor domain containing 3. (796 aa)
topbp1DNA topoisomerase II binding protein 1. (1509 aa)
ENSXMAP00000025712BRCT domain-containing protein. (149 aa)
blmBLM RecQ like helicase. (1398 aa)
ankrd11Ankyrin repeat domain 11. (2826 aa)
xrcc2X-ray repair cross complementing 2. (311 aa)
rpa3Replication protein A3. (122 aa)
palb2PALB2_WD40 domain-containing protein. (1346 aa)
dna2Uncharacterized protein. (1324 aa)
LOC102230232RPA_C domain-containing protein. (247 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (600 aa)
rad52RAD52 homolog, DNA repair protein. (445 aa)
rad50RAD50 homolog, double strand break repair protein. (1312 aa)
bard1BRCA1 associated RING domain 1. (800 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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