(26 nodes) Homologous DNA Pairing and Strand Exchange, and Helicase-like, DEXD box c2 type network (Xiphophorus maculatus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	rad51	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa)
	LOC102224037	Checkpoint kinase 2. (442 aa)
	rad51c	RAD51 paralog C. (352 aa)
	mre11	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (743 aa)
	rtel1	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1165 aa)
	brip1	BRCA1 interacting protein C-terminal helicase 1. (1188 aa)
	rbbp8	Uncharacterized protein. (638 aa)
	brca2	BRCA2 DNA repair associated. (3052 aa)
	nbn	Nibrin. (831 aa)
	xrcc3	DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (364 aa)
	atr	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2443 aa)
	brca1	Uncharacterized protein. (1370 aa)
	exo1	Exonuclease 1. (777 aa)
	rad51d	RAD51 paralog D. (339 aa)
	recql4	RecQ helicase-like 4. (1385 aa)
	atm	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2875 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1252 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1509 aa)
	ENSXMAP00000025712	BRCT domain-containing protein. (149 aa)
	ankrd11	Ankyrin repeat domain 11. (2826 aa)
	xrcc2	X-ray repair cross complementing 2. (311 aa)
	palb2	PALB2_WD40 domain-containing protein. (1346 aa)
	dna2	Uncharacterized protein. (1324 aa)
	rad52	RAD52 homolog, DNA repair protein. (445 aa)
	rad50	RAD50 homolog, double strand break repair protein. (1312 aa)
	bard1	BRCA1 associated RING domain 1. (800 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSXMAP00000025712	LOC102224037	ENSXMAP00000025712	ENSXMAP00000001234	BRCT domain-containing protein.	Checkpoint kinase 2.	0.543
ENSXMAP00000025712	atm	ENSXMAP00000025712	ENSXMAP00000016978	BRCT domain-containing protein.	ATM serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.898
ENSXMAP00000025712	atr	ENSXMAP00000025712	ENSXMAP00000009308	BRCT domain-containing protein.	ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family.	0.959
ENSXMAP00000025712	bard1	ENSXMAP00000025712	ENSXMAP00000039651	BRCT domain-containing protein.	BRCA1 associated RING domain 1.	0.995
ENSXMAP00000025712	brca1	ENSXMAP00000025712	ENSXMAP00000009963	BRCT domain-containing protein.	Uncharacterized protein.	0.880
ENSXMAP00000025712	brca2	ENSXMAP00000025712	ENSXMAP00000006983	BRCT domain-containing protein.	BRCA2 DNA repair associated.	0.752
ENSXMAP00000025712	brip1	ENSXMAP00000025712	ENSXMAP00000005755	BRCT domain-containing protein.	BRCA1 interacting protein C-terminal helicase 1.	0.906
ENSXMAP00000025712	dna2	ENSXMAP00000025712	ENSXMAP00000034706	BRCT domain-containing protein.	Uncharacterized protein.	0.842
ENSXMAP00000025712	exo1	ENSXMAP00000025712	ENSXMAP00000010534	BRCT domain-containing protein.	Exonuclease 1.	0.806
ENSXMAP00000025712	mre11	ENSXMAP00000025712	ENSXMAP00000004014	BRCT domain-containing protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.837
ENSXMAP00000025712	nbn	ENSXMAP00000025712	ENSXMAP00000006994	BRCT domain-containing protein.	Nibrin.	0.904
ENSXMAP00000025712	rad50	ENSXMAP00000025712	ENSXMAP00000039533	BRCT domain-containing protein.	RAD50 homolog, double strand break repair protein.	0.823
ENSXMAP00000025712	rad51	ENSXMAP00000025712	ENSXMAP00000000592	BRCT domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.621
ENSXMAP00000025712	rad51c	ENSXMAP00000025712	ENSXMAP00000003353	BRCT domain-containing protein.	RAD51 paralog C.	0.508
ENSXMAP00000025712	rad51d	ENSXMAP00000025712	ENSXMAP00000011507	BRCT domain-containing protein.	RAD51 paralog D.	0.621
ENSXMAP00000025712	rad52	ENSXMAP00000025712	ENSXMAP00000036981	BRCT domain-containing protein.	RAD52 homolog, DNA repair protein.	0.807
ENSXMAP00000025712	rbbp8	ENSXMAP00000025712	ENSXMAP00000006407	BRCT domain-containing protein.	Uncharacterized protein.	0.449
ENSXMAP00000025712	recql4	ENSXMAP00000025712	ENSXMAP00000015360	BRCT domain-containing protein.	RecQ helicase-like 4.	0.811
ENSXMAP00000025712	rtel1	ENSXMAP00000025712	ENSXMAP00000004639	BRCT domain-containing protein.	Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...]	0.906
ENSXMAP00000025712	tp53bp1	ENSXMAP00000025712	ENSXMAP00000018299	BRCT domain-containing protein.	Tumor protein p53 binding protein, 1.	0.927