STRINGSTRING
mcm2 mcm2 MCMDC2 MCMDC2 rfc5 rfc5 gins2 gins2 timeless timeless pole4 pole4 cdc7 cdc7 LOC102220076 LOC102220076 mcm5 mcm5 orc5 orc5 lig1 lig1 pold3 pold3 ten1 ten1 fen1 fen1 chtf8 chtf8 dbf4 dbf4 polk polk chtf18 chtf18 pole pole orc3 orc3 sass6 sass6 pole2 pole2 mcm10 mcm10 prim2 prim2 rfc1 rfc1 pola2 pola2 wdhd1 wdhd1 stn1 stn1 polh polh orc4 orc4 dscc1 dscc1 rev1 rev1 pold1 pold1 pold4 pold4 cdc6 cdc6 LOC102218031 LOC102218031 cdc45 cdc45 pcna pcna pold2 pold2 gins3 gins3 mcm7 mcm7 CLSPN CLSPN prim1 prim1 mcm6 mcm6 mad2l2 mad2l2 gins1 gins1 ctc1 ctc1 pola1 pola1 gins4 gins4 poli poli ENSXMAP00000024871 ENSXMAP00000024871 rev3l rev3l rfc2 rfc2 rfc4 rfc4 rad17 rad17 Mcmbp Mcmbp mcm8 mcm8 Mcm9 Mcm9 tipin tipin orc2 orc2 mcm3 mcm3 pole3 pole3 cdt1 cdt1 orc1 orc1 mcm4 mcm4 rfc3 rfc3 LOC111609834 LOC111609834
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
mcm2DNA helicase; Belongs to the MCM family. (886 aa)
MCMDC2Minichromosome maintenance domain containing 2. (649 aa)
rfc5Replication factor C (activator 1) 5. (335 aa)
gins2DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (186 aa)
timelessTimeless circadian clock. (1260 aa)
pole4Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
cdc7Cell division cycle 7 homolog (S. cerevisiae). (606 aa)
LOC102220076Zgc:110269. (347 aa)
mcm5DNA helicase; Belongs to the MCM family. (695 aa)
orc5Origin recognition complex, subunit 5. (442 aa)
lig1DNA ligase. (595 aa)
pold3Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
ten1TEN1 subunit of CST complex. (132 aa)
fen1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
chtf8CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (133 aa)
dbf4DBF4 zinc finger. (593 aa)
polkPolymerase (DNA directed) kappa. (935 aa)
chtf18AAA domain-containing protein. (922 aa)
poleDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
orc3Origin recognition complex, subunit 3. (722 aa)
sass6SAS-6 centriolar assembly protein. (582 aa)
pole2DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
mcm10Minichromosome maintenance 10 replication initiation factor. (870 aa)
prim2DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (501 aa)
rfc1Replication factor C subunit 1. (1195 aa)
pola2DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
wdhd1WD repeat and HMG-box DNA binding protein 1. (1102 aa)
stn1CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (359 aa)
polhPolymerase (DNA directed), eta. (720 aa)
orc4Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (434 aa)
dscc1DNA replication and sister chromatid cohesion 1. (390 aa)
rev1REV1 DNA directed polymerase. (1363 aa)
pold1DNA polymerase. (1105 aa)
pold4Si:dkey-28b4.7. (108 aa)
cdc6Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (579 aa)
LOC102218031ATPase family AAA domain containing 5a. (1810 aa)
cdc45CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
pcnaProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
pold2Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa)
gins3GINS complex subunit 3. (211 aa)
mcm7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
CLSPNClaspin. (1202 aa)
prim1DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
mcm6DNA helicase; Belongs to the MCM family. (816 aa)
mad2l2Mitotic arrest deficient 2 like 2. (210 aa)
gins1GINS complex subunit 1 (Psf1 homolog). (189 aa)
ctc1Uncharacterized protein. (794 aa)
pola1DNA polymerase. (1488 aa)
gins4DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (224 aa)
poliPolymerase (DNA directed) iota. (708 aa)
ENSXMAP00000024871MCM domain-containing protein; Belongs to the MCM family. (351 aa)
rev3lREV3 like, DNA directed polymerase zeta catalytic subunit. (3006 aa)
rfc2Replication factor C (activator 1) 2. (357 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
rad17RAD17 checkpoint clamp loader component. (616 aa)
McmbpUncharacterized protein. (112 aa)
mcm8Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (846 aa)
Mcm9Uncharacterized protein. (158 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (290 aa)
orc2Origin recognition complex, subunit 2. (594 aa)
mcm3DNA helicase; Belongs to the MCM family. (836 aa)
pole3Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
cdt1Chromatin licensing and DNA replication factor 1. (761 aa)
orc1Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (890 aa)
mcm4DNA helicase; Belongs to the MCM family. (868 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
LOC111609834DBF4-type domain-containing protein. (692 aa)
Your Current Organism:
Xiphophorus maculatus
NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish
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