(35 nodes) Telomere C-strand (Lagging Strand) Synthesis, and Error-prone translesion synthesis network (Xiphophorus maculatus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	rfc5	Replication factor C (activator 1) 5. (335 aa)
	pole4	Polymerase (DNA-directed), epsilon 4, accessory subunit. (129 aa)
	LOC102220076	Zgc:110269. (347 aa)
	lig1	DNA ligase. (595 aa)
	pold3	Polymerase (DNA-directed), delta 3, accessory subunit. (438 aa)
	ten1	TEN1 subunit of CST complex. (132 aa)
	fen1	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa)
	chtf8	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (133 aa)
	polk	Polymerase (DNA directed) kappa. (935 aa)
	chtf18	AAA domain-containing protein. (922 aa)
	pole	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2281 aa)
	sass6	SAS-6 centriolar assembly protein. (582 aa)
	pole2	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (528 aa)
	prim2	DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (501 aa)
	rfc1	Replication factor C subunit 1. (1195 aa)
	pola2	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (603 aa)
	stn1	CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (359 aa)
	polh	Polymerase (DNA directed), eta. (720 aa)
	dscc1	DNA replication and sister chromatid cohesion 1. (390 aa)
	rev1	REV1 DNA directed polymerase. (1363 aa)
	pold1	DNA polymerase. (1105 aa)
	pold4	Si:dkey-28b4.7. (108 aa)
	LOC102218031	ATPase family AAA domain containing 5a. (1810 aa)
	pcna	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	pold2	Polymerase (DNA directed), delta 2, regulatory subunit. (528 aa)
	prim1	DNA primase; Belongs to the eukaryotic-type primase small subunit family. (426 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (210 aa)
	ctc1	Uncharacterized protein. (794 aa)
	poli	Polymerase (DNA directed) iota. (708 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (3006 aa)
	rfc2	Replication factor C (activator 1) 2. (357 aa)
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	rad17	RAD17 checkpoint clamp loader component. (616 aa)
	pole3	Polymerase (DNA directed), epsilon 3 (p17 subunit). (150 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC102218031	LOC102220076	ENSXMAP00000014316	ENSXMAP00000004359	ATPase family AAA domain containing 5a.	Zgc:110269.	0.909
LOC102218031	chtf18	ENSXMAP00000014316	ENSXMAP00000007634	ATPase family AAA domain containing 5a.	AAA domain-containing protein.	0.905
LOC102218031	chtf8	ENSXMAP00000014316	ENSXMAP00000006184	ATPase family AAA domain containing 5a.	CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae).	0.730
LOC102218031	ctc1	ENSXMAP00000014316	ENSXMAP00000021700	ATPase family AAA domain containing 5a.	Uncharacterized protein.	0.549
LOC102218031	dscc1	ENSXMAP00000014316	ENSXMAP00000010879	ATPase family AAA domain containing 5a.	DNA replication and sister chromatid cohesion 1.	0.859
LOC102218031	fen1	ENSXMAP00000014316	ENSXMAP00000006136	ATPase family AAA domain containing 5a.	Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...]	0.909
LOC102218031	lig1	ENSXMAP00000014316	ENSXMAP00000005879	ATPase family AAA domain containing 5a.	DNA ligase.	0.873
LOC102218031	mad2l2	ENSXMAP00000014316	ENSXMAP00000019434	ATPase family AAA domain containing 5a.	Mitotic arrest deficient 2 like 2.	0.687
LOC102218031	pcna	ENSXMAP00000014316	ENSXMAP00000014924	ATPase family AAA domain containing 5a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.981
LOC102218031	pola2	ENSXMAP00000014316	ENSXMAP00000009802	ATPase family AAA domain containing 5a.	DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.	0.886
LOC102218031	pold1	ENSXMAP00000014316	ENSXMAP00000011793	ATPase family AAA domain containing 5a.	DNA polymerase.	0.832
LOC102218031	pold2	ENSXMAP00000014316	ENSXMAP00000015386	ATPase family AAA domain containing 5a.	Polymerase (DNA directed), delta 2, regulatory subunit.	0.715
LOC102218031	pold3	ENSXMAP00000014316	ENSXMAP00000006066	ATPase family AAA domain containing 5a.	Polymerase (DNA-directed), delta 3, accessory subunit.	0.693
LOC102218031	pole	ENSXMAP00000014316	ENSXMAP00000007836	ATPase family AAA domain containing 5a.	DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family.	0.901
LOC102218031	pole2	ENSXMAP00000014316	ENSXMAP00000008217	ATPase family AAA domain containing 5a.	DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family.	0.864
LOC102218031	pole3	ENSXMAP00000014316	ENSXMAP00000037553	ATPase family AAA domain containing 5a.	Polymerase (DNA directed), epsilon 3 (p17 subunit).	0.789
LOC102218031	pole4	ENSXMAP00000014316	ENSXMAP00000003364	ATPase family AAA domain containing 5a.	Polymerase (DNA-directed), epsilon 4, accessory subunit.	0.673
LOC102218031	polh	ENSXMAP00000014316	ENSXMAP00000010617	ATPase family AAA domain containing 5a.	Polymerase (DNA directed), eta.	0.691
LOC102218031	poli	ENSXMAP00000014316	ENSXMAP00000024273	ATPase family AAA domain containing 5a.	Polymerase (DNA directed) iota.	0.639
LOC102218031	polk	ENSXMAP00000014316	ENSXMAP00000007045	ATPase family AAA domain containing 5a.	Polymerase (DNA directed) kappa.	0.687