(5 nodes) MCM N-terminal domain network (Xiphophorus maculatus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mcm5	DNA helicase; Belongs to the MCM family. (695 aa)
	cdc45	CDC45 cell division cycle 45 homolog (S. cerevisiae). (570 aa)
	mcm7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (724 aa)
	mcm6	DNA helicase; Belongs to the MCM family. (816 aa)
	mcm4	DNA helicase; Belongs to the MCM family. (868 aa)

Your Current Organism:

Xiphophorus maculatus

NCBI taxonomy Id: 8083
Other names: Platypoecilus maculatus, X. maculatus, southern platyfish

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cdc45	mcm4	ENSXMAP00000014808	ENSXMAP00000040329	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm5	ENSXMAP00000014808	ENSXMAP00000004570	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm6	ENSXMAP00000014808	ENSXMAP00000018349	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA helicase; Belongs to the MCM family.	0.999
cdc45	mcm7	ENSXMAP00000014808	ENSXMAP00000016376	CDC45 cell division cycle 45 homolog (S. cerevisiae).	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
mcm4	cdc45	ENSXMAP00000040329	ENSXMAP00000014808	DNA helicase; Belongs to the MCM family.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.999
mcm4	mcm5	ENSXMAP00000040329	ENSXMAP00000004570	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm4	mcm6	ENSXMAP00000040329	ENSXMAP00000018349	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm4	mcm7	ENSXMAP00000040329	ENSXMAP00000016376	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
mcm5	cdc45	ENSXMAP00000004570	ENSXMAP00000014808	DNA helicase; Belongs to the MCM family.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.999
mcm5	mcm4	ENSXMAP00000004570	ENSXMAP00000040329	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm5	mcm6	ENSXMAP00000004570	ENSXMAP00000018349	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm5	mcm7	ENSXMAP00000004570	ENSXMAP00000016376	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
mcm6	cdc45	ENSXMAP00000018349	ENSXMAP00000014808	DNA helicase; Belongs to the MCM family.	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.999
mcm6	mcm4	ENSXMAP00000018349	ENSXMAP00000040329	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm6	mcm5	ENSXMAP00000018349	ENSXMAP00000004570	DNA helicase; Belongs to the MCM family.	DNA helicase; Belongs to the MCM family.	0.999
mcm6	mcm7	ENSXMAP00000018349	ENSXMAP00000016376	DNA helicase; Belongs to the MCM family.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.999
mcm7	cdc45	ENSXMAP00000016376	ENSXMAP00000014808	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	CDC45 cell division cycle 45 homolog (S. cerevisiae).	0.999
mcm7	mcm4	ENSXMAP00000016376	ENSXMAP00000040329	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
mcm7	mcm5	ENSXMAP00000016376	ENSXMAP00000004570	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999
mcm7	mcm6	ENSXMAP00000016376	ENSXMAP00000018349	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	DNA helicase; Belongs to the MCM family.	0.999